10 research outputs found
Investigating the phosphinic acid tripeptide mimetic DG013A as a tool compound inhibitor of the M1-aminopeptidase ERAP1.
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 15/06/2021
- Field of study
ERAP1 is a zinc-dependent M1-aminopeptidase that trims lipophilic amino acids from the N-terminus of peptides. Owing to its importance in the processing of antigens and regulation of the adaptive immune response, dysregulation of the highly polymorphic ERAP1 has been implicated in autoimmune disease and cancer. To test this hypothesis and establish the role of ERAP1 in these disease areas, high affinity, cell permeable and selective chemical probes are essential. DG013A 1, is a phosphinic acid tripeptide mimetic inhibitor with reported low nanomolar affinity for ERAP1. However, this chemotype is a privileged structure for binding to various metal-dependent peptidases and contains a highly charged phosphinic acid moiety, so it was unclear whether it would display the high selectivity and passive permeability required for a chemical probe. Therefore, we designed a new stereoselective route to synthesize a library of DG013A 1 analogues to determine the suitability of this compound as a cellular chemical probe to validate ERAP1 as a drug discovery target
Enzyme-Linked Immunoadsorbent Assays for Myelin Basic Protein and Antibodies to Myelin Basic Protein
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the Heat Shock Factor (HSF1) stress pathway and CDK9
- Author
- Publication venue
- 'Royal Society of Chemistry (RSC)'
- Publication date
- Field of study
Yersinia arthritis: a clinical, immunological, and family study of 2 cases.
- Author
- A Dunk A.
- Aho K.
- Ahvonen P.
- Benacerraf B, McDevitt H 0
- Biozzi G.
- Chessum B.
- Corrigall V.
- E Fox
- E Baldock N.
- E Thorpe P.
- F Bakken A.
- F Geczy A.
- Granfors K.
- H Lay W.
- J Sheldon P.
- K Ford D.
- Laitinen 0 Tuuhea J, Ahvonen P
- Leino R.
- M Berden J.H.
- M Greenwood B.
- McDevitt H 0 Chinitz A
- Myllyla G.
- N S Mair
- P J Sheldon
- Paronen I.
- Pease P.
- Reiter H.
- Romanus R.
- Rosenthal L.
- S Dhaliwal H.
- Schlosstein L.
- T Masi A.
- T Scott J.
- Vairtainen J.
- W Ebringer R.
- W Warren C.P.
- Wiener E.
- Y Bulgen D.
- Publication venue
- 'BMJ'
- Publication date
- Field of study
Advances in the biology of sporozoa
- Author
- A. H. Corner
- A. Haberkorn
- A. Harboe
- A. J. Vos De
- A. Ruiz
- A. W. McCracken
- A.-O. Heydorn
- A.-O. Heydorn
- A.-O. Heydorn
- B. B. Gallucci
- B. L. Munday
- B. S. Chessum
- C. A. Speer
- C. R. Sterling
- D. G. Fleck
- D. J. Doran
- D. Kïżœhn
- D. L. DeGiusti
- D. M. Hammond
- D. W. Duszynski
- E. Biocca
- E. D. Box
- E. E. McConnell
- E. E. McConnell
- E. M. Liburd
- E. Sadun
- E. Sadun
- E. Scholtyseck
- E. Scholtyseck
- E. Scholtyseck
- E. Scholtyseck
- E. Vivier
- F. Hawking
- F. Hawking
- F. I. Awad
- G. C. Shelton
- G. D. Wallace
- G. D. Wallace
- G. D. Wallace
- G. D. Wallace
- G. D. Wallace
- G. D. Wallace
- G. D. Wallace
- G. D. Wallace
- G. D. Wallace
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- G. H. Ball
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- R. Lainson
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- W. M. Hutchison
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- W. M. Reid
- W. Trager
- Y. Boulard
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1974
- Field of study
Recovery of uncommon bacteria from blood: association with neoplastic disease
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- Abrams E.
- Allen K. D.
- Alpern R. J.
- Alpern R. J.
- Andes W. A.
- Applebaum P. C.
- Armstrong D.
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- Auckenthaler R.
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- Publication venue
- 'American Society for Microbiology'
- Publication date
- Field of study
Targeted protein degradation as a powerful research tool in basic biology and drug target discovery
- Author
- A Boija
- A Ciechanover
- A Schlierf
- AK Gandhi
- B Jiang
- B Nabet
- B Pan
- C Renicke
- C Schwechheimer
- CC Ward
- CM Armstrong
- CP Tinworth
- D Clift
- D Takahashi
- DA Thomas
- DE Bussiere
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- DL Buckley
- DL Buckley
- DP Bondeson
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- DS Goodsell
- E Caussinus
- EC Fink
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- EJ Fay
- ES Fischer
- F Rago
- G Lu
- G Petzold
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- GE Winter
- GF Watt
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- GM Burslem
- GV Los
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- MA Erb
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- NEA Chessum
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- QL Sievers
- R Hjerpe
- R Martin
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- RP Nowak
- RW King
- S BasuRay
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- S Teo
- S Tomoshige
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- ZI Bassi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
PROTACs: great opportunities for academia and industry
- Author
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- A Asmat
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- A Dubrovska
- A Feki
- A Lopez-Girona
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- AD Buhimschi
- AE Perl
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- AJ Mohamed
- AL Dent
- AP Crew
- AR Schneekloth
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- BA Gibson
- BE Kessler
- BE Smith
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- C Nguyen
- C Ozvegy-Laczka
- C Qin
- C Schiano
- C Simone
- C Steinebach
- C Steinebach
- C Yang
- C Zhang
- C-Y Yang
- CA Bradbury
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- CH Kang
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- DR Camidge
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- F Hayakawa
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- MC Frame
- MD Schaller
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- MG Cardenas
- MJ Roy
- MJ van Nimwegen
- MJ Walczak
- ML Drummond
- MM Gounder
- MM Schittenhelm
- MS Gadd
- MS Redell
- N Dey
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- N Ohoka
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- N Ohoka
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- NP Shah
- O Hantschel
- O Hantschel
- O Rosnet
- P De Paepe
- P Francica
- P Liu
- P Ottis
- P Pfaff
- P Puigserver
- P Wang
- P Wu
- PE Czabotar
- PM Cromm
- PM Fischer
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- R Margueron
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- R Vimalavathini
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- RP Nowak
- RP Wurz
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- SJ Hughes
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- SW Morris
- SY Li
- T Kaur
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- T Kobayashi
- T Rzymski
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- TT Chu
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- V Giguere
- V Kasinath
- V Kerekatte
- V Krystof
- V Zoppi
- VA Gupta
- W Anastasia
- W Farnaby
- W Fiedler
- W Li
- W McCoull
- W Wang
- W Zhu
- W-S Huang
- WG Roberts
- WS Xu
- X Wang
- Y Chen
- Y Itoh
- Y Itoh
- Y Itoh
- Y Jia
- Y Jung
- Y Mamane
- Y Odia
- Y Song
- Y Sun
- Y Sun
- Y Yamamoto
- Y Yang
- Y Zhan
- Y Zou
- YA Sonawane
- YB Li
- YL Choi
- YL Liu
- YY Yeh
- Z An
- Z Liu
- Z Pan
- Z Wang
- Z Zheng
- ZI Bassi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
PARTâTIME WORKING IN IRELAND
- Author
- A Study of the Demand for Part-time Labour and Sex Discrimination in Selected Organizations and Establishments
- Action Travail
- Agassi J. B.
- Ahern B.
- Allen S.
- Angier M.M.
- Anon
- Anon
- Anon
- Anon
- Anon
- Association of Scientific Technical and Managerial Staffs
- Atkinson J.
- Atkinson J.
- Ballard B.
- Barry U.
- Basnett D.
- Bednarzik B.W.
- Beechey V.
- Beechey V.
- Beechey V.
- Beechey V.
- Beechey V.
- Beechey V.
- Bekemans L
- Best F.
- Bielensky H.
- Blackstone T.
- Blackwell J.
- Blackwell J.
- Blackwell J.
- Blackwell J.
- Blackwell J.
- Blyton P.
- Blyton P.
- Boddendijk F.R.
- Borchorst A.
- Bosworth D.
- Briar C.
- Casey B.
- Cassells P.
- Central Statistical Office
- Central Statistical Office
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