189 research outputs found
Selectivity of DNA polymerases toward α and β nucleotide substrates of d and l series
AbstractThe substrate properties of four carbocyclic d and l nucleoside 5′-triphosphate analogs toward HIV and AMV reverse transcriptases and terminal deoxynucleotidyl transferase were evaluated. The compounds of the d-β and l-β series were found to be terminating substrates for these enzymes, while the derivatives of the d-α and l-α series were recognized only by terminal deoxynucleotidyl transferase, suggesting that for the template-independent enzyme the mutual orientation of the two fragments is of no significance. A hypothesis for binding of nucleotides to the DNA polymerase active center was proposed
ChemInform Abstract: Synthesis of Novel Pyrene-Bearing C-Nucleoside and Its Incorporation into Oligonucleotides
ChemInform Abstract: Modified Triphosphates of Carbocyclic Nucleoside Analogues: Synthesis, Stability Towards Alkaline Phosphatase and Substrate Properties for Some DNA Polymerases.
ChemInform Abstract: Aminonucleotides and Their Derivatives. Part 13. Synthesis of Benzimidazole Azidonucleotides.
ChemInform Abstract: Aminonucleosides and Their Derivatives. Part 12. A New Synthesis of 1-O-Methyl-3-azido-2,3-dideoxy-D-ribofuranose.
ChemInform Abstract: Synthesis and Substrate Properties of Thymidine 5′-Triphosphate Analogues with Large Hydrophobic Substituent Groups at α-P Atom.
ChemInform Abstract: Formation and Reactivity of 2,4-Ditriazolyl Pyrimidine C-Nucleoside Derived from Pseudouridine.
ChemInform Abstract: Nucleoside von Fluorzuckern. 15. Mitt. Synthese von 2′,3′-Didesoxy-3′-fluor-D-ribofuranosyl-benzimidazol - ein neues Fluorzucker-Purinnucleosidanalogon.
Methyl 5-O--butyldiphenylsilyl-2-deoxy-D-threo-pentofuranoside; an approach to the syntesis of 3′-substituted-2′,3′-dideoxynucleosides including 3′-azido-3′-deoxythymidine and of 3′-substituted-2′,3′-dideoxy-C-nucleosides
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