Linguistic Experiments in Rushdie’s Midnight’s Children

The popularity of Salman Rushdie's novel 'Midnight’s Children' (1981) rests on two things: the innovative use of English as a language, and the fantastic representation of history. While Rushdie resorts to the use of ‘magic realism’ to oppose the Euro-centrism of master discourses, the innovativeness of Rushdie’s English is prompted by a desire to capture the spirit of Indian culture with all its multiplicity and diversity. As a linguistic experimentalist, Rushdie attempts to destroy ‘the natural rhythms of the English language’ and to dislocate ‘the English and let other things into it’. Rushdie’s Midnight’s Children best illustrates his strategy of ‘Indianising, revitalising and decolonising the English language’. Here in this paper, I shall try to highlight the linguistic innovations of Salman Rushdie in his Midnight’s Children

Un tiempo de oscuridad: El proyecto anticolonial de Satyajit Ray

Satyajit Ray’s films are enriched with ideological concerns and engage with the issues of colonialism and the crisis of nationhood. His post 1970 films present an artist’s anguished response to the betrayal of the Nehruvian dream and to the anachronism of his own cherished values. It was also in this period that Ray turned to India’s colonial past and critiqued the dynamics of power relations. This essay studies how Shatranj ke Khilari (The Chess Players, 1980) assesses the reasons for colonization of India and its culture by the Britishers and how, in Ashani Sanket (Distant Thunder, 1973), he criticized the Raj, the mercenaries and the complexities in Indian society where he denounces the Bengal Famine of former times.Las películas de Satyajit Ray muestran su perfil ideológico e interpelan a las temáticas del colonialismo y la crisis de nacionalidad. Las películas que dirigió después de 1970 muestran la respuesta ansiosa que suponía la traición a los valores de Nehru y el anacronismo de los valores que Ray consideraba necesarios. En este período Ray también investigó el pasado colonial de India y denunció la dinámica de las relaciones de poder que existieron. Este ensayo estudia cómo Shatranj ke Khilari (Los jugadores de ajedrez, 1980) evalúa las razones culturales por las que India fue colonizada por Reino Unido y, en Ashani Sanket (Trueno distante, 1973), critica el Raj, los que cometieron crímenes despiadados y las complejidades de la sociedad india de la época, arremetiendo especialmente contra las condiciones que desencadenaros la Hambruna en Bengala

Common variants of FTO are associated with childhood obesity in a cross-sectional study of 3,126 urban Indian children

Background: FTO variants are robustly associated with obesity and related traits in many population and shown to have variable impact during life course. Although studies have shown association of FTO variants with adiposity in adult Indian, its association in Indian children is yet to be confirmed. Methods: Here we examined association of FTO variants (rs9939609 and rs8050136) with obesity and related anthropometric and biochemical traits in 3,126 Indian children (aged 11–17 years) including 2,230 normal-weight and 896 over-weight/obese children. We also compared effects observed in the present study with that observed in previous studies on South Asian adults and children of other ethnic groups. Results: The variant rs9939609 showed significant association with risk of obesity [OR = 1.21, P = 2.5×10−3] and its measures BMI, weight, waist circumference and hip circumference [β range = 0.11 to 0.14 Z-score units; P range = 1.3×10−4 to 1.6×10−7] in children. The observed effect sizes in Indian children were similar to those reported for European children. Variant rs9939609 explained 0.88% of BMI variance in Indian children. The effect sizes of rs9939609 on BMI and WC were ∼2 fold higher in children than adults. Interestingly rs9939609 was also associated with serum levels of thyroid stimulating hormone (TSH) [β = 0.10 Z-score, P = 5.8×10−3]. The other variant rs8050136 was in strong linkage disequilibrium with rs9939609 (r2 = 0.97) and provided similar association results. Conclusion: The study provides first report of association of FTO variants with obesity and related anthropometric traits in Indian children with higher impact in children compared to adults. We also demonstrated association of FTO variant with serum levels of TSH, indicating putative influence of FTO in hypothalamic-pituitary-thyroid axis

Vegetable Cultivation under Hydroponics in Himalayas : Challenges and Opportunities

Defence Institute of Bio-Energy Research, Haldwani has successfully developed a hydroponics system by clubbing the soil less cultivation with rain water harvesting technology. The institute has also developed a suitable nutrient composition suitable for wide range of vegetables. Among the various varieties/hybrids grown in hydroponics, cucumber line PC 4C-8 exhibited the maximum fruit yield (448.3 q/ha). Among the various tomato hybrids, Avinash-2 exhibited highest yield (1052 q/ha) and number of fruits (154 per sq m) whereas TSS, total sugars, crude protein and minerals content were the maximum in tomato hybrid DARL-304. Interestingly, hydroponics system prolonged the harvesting period by 45 days in tomato. Plant population density of 6 plants/m2 was found optimum with the highest fruit yield in tomato and cucumber. Tomato hybrid DARL-304 exhibited higher fruit yield (6.5 kg/plant). Hydroponics system have been found successful in Auli (9000’ MSL), Joshimath with fruit yield of 2.25 kg/plant to 3.79 kg/plant in tomato. The yield was higher in rain water as comparison to river water. The article deals with the hydroponics technology in detail vis-à-vis efforts made at DIBER for standardization of hydroponics technology. It is envisaged that experience gained in successful cultivation of various crops in hydroponics using single nutrient solution at various altitudes through research stations of the institute

Common Variants of Homocysteine Metabolism Pathway Genes and Risk of Type 2 Diabetes and Related Traits in Indians

Hyperhomocysteinemia, a risk factor for cardiovascular disorder, obesity, and type 2 diabetes, is prevalent among Indians who are at high risk of these metabolic disorders. We evaluated association of common variants of genes involved in homocysteine metabolism or its levels with type 2 diabetes, obesity, and related traits in North Indians. We genotyped 90 variants in initial phase (2.115 subjects) and replicated top signals in an independent sample set (2.085 subjects). The variant MTHFR-rs1801133 was the top signal for association with type 2 diabetes (OR = 0.78 (95%  CI = 0.67–0.92), P = 0.003) and was also associated with 2 h postload plasma glucose (P = 0.04), high-density lipoprotein cholesterol (P = 0.004), and total cholesterol (P = 0.01) in control subjects. These associations were neither replicated nor significant after meta-analysis. Studies involving a larger study population and different ethnic groups are required before ruling out the role of these important candidate genes in type 2 diabetes, obesity, and related traits

Role of Basti Karma towards the management of Madhumeha: an Ayurveda perspective

Ayurveda the Indian medical system mentioned Madhumeha as imbalance of the Doshas; Vata, Pitta and Kapha. Madhumeha correlated with diabetes as per modern medical science characterized by hyperglycemia and disturbance of water and electrolyte homeostasis. In Ayurveda (Brihatrayi) it is considered as Ashta mahagada as difficult to cure. It is also relates with life-style related metabolic disorder since consumption of junk foods, day time sleep, lack of exercises and sedentary habits may precipitate symptoms of diabetes. Now a day’s Madhumeha has become very common pathological condition affecting more than 20% of world population. Madhumeha may be managed by good conduction of Ahara-Vihara, Yoga, Sodhana karma and use of various ayurveda formulations, however recently Panchakarma has gain great attention towards the management of Madhumeha since some specific modalities of Panchakarma effectively removes vitiated Doshas and Vasti Karma is one of them. Considering this aspect present article summarized ayurveda perspective of Basti Karma towards the management of Madhumeha. Keywords: Ayurveda, Diabetes, Madhumeha, Panchakarma, Basti Karma

Green Route for Efficient Synthesis of Novel Amino Acid Schiff Bases as Potent Antibacterial and Antifungal Agents and Evaluation of Cytotoxic Effects

Green chemical one-pot multicomponent condensation reaction of substituted 1H-indole-2,3-diones (1), various amino acids (2), and thiosemicarbazide (3) is found to be catalyzed by lemon juice as natural acid using water as a green solvent to give the corresponding Schiff bases (4) in good to excellent yields. This method is experimentally simple, clean, high yielding, and green, with reduced reaction times. The product is purified by simple filtration followed by washing with water and drying process. The synthesized compounds are characterized by FT-IR, 13 CNMR, and 1 HNMR spectroscopy and are screened for their antifungal activity against Aspergillus niger, Penicillium notatum, Fusarium oxysporum, Alternaria brassicicola, Chaetomium orium, and Lycopodium sp. and antibacterial activity against Gram-positive bacteria, Bacillus licheniformis, Staphylococcus aureus, and Micrococcus luteus, and Gram-negative bacteria, Pseudomonas aeruginosa and Escherichia coli. Compounds have also been evaluated for cytotoxic effects against human colon cancer cell line Colo205

Investigation of some trace elements in Raipur Industrial area and its surrounding, Raipur District.

The paper deals with determination of eight trace metals namely. Copper, Iron, Mangnese, Zinc, Nickel,, Chromium  Lead and Mercury  in the ground water of different sites of Raipur Industrial area of Raipur district . All activities carried out on the ground surface have direct or indirect impact on the ground water whether associated with urban ,industrial or agricultural activities large scale concentrated source of pollutants, such as industrial discharges and sub surface injection of chemicals and hazardous are obvious source of ground water pollutants. This study was carryout in the month of during summer 2013. The samples were collected from seven different source of Raipur Industrial area of Raipur. The results obtained are compared with safe limits in ppm for heavy metals laid down by BIS, WHO, ICMR, APHA

An important role of coal and its calorific value on the performance of thermal power station: A case study

An investigation was undertaken to study the Physical and Chemical properties of coal in Korba district. Due to the Presence of lot of Coal mines, number of coal based thermal power stations are established in Korba district. So study has been carried out for assessment of coal quality, whether it is suitable for thermal power stations, by collectying sample from Gevra Coal mines. This paper presents Grade of the coal available in Korba district. Three different Coal samples were collected from  different areas of Gevra Coal mines  and analyzed for Proximate, Ultimate and  Calorific value as per Standard methods. The useful heat values (UHV) of three coal samples are 2482K.Cal/Kg, 2917K.Cal/Kg, and 2786K.Cal/Kg. From overall analysis, and according to UHV of coal samples  we can conclude that  the grade of Gevra Coal is” F”and is very much  useful for Coal based thermal power stations

A multigenerational study on phenotypic consequences of the most common causal variant of HNF1A-MODY

Correction: Volume65, Issue5 Page: 912-912 DOI: 10.1007/s00125-022-05663-z Published: MAY 2022 Early Access: MAR 2022Aims/hypothesis Systematic studies on the phenotypic consequences of variants causal of HNF1A-MODY are rare. Our aim was to assess the phenotype of carriers of a single HNF1A variant and genetic and clinical factors affecting the clinical spectrum. Methods We conducted a family-based multigenerational study by comparing heterozygous carriers of the HNF1A p.(Gly292fs) variant with the non-carrier relatives irrespective of diabetes status. During more than two decades, 145 carriers and 131 non-carriers from 12 families participated in the study, and 208 underwent an OGTT at least once. We assessed the polygenic risk score for type 2 diabetes, age at onset of diabetes and measures of body composition, as well as plasma glucose, serum insulin, proinsulin, C-peptide, glucagon and NEFA response during the OGTT. Results Half of the carriers remained free of diabetes at 23 years, one-third at 33 years and 13% even at 50 years. The median age at diagnosis was 21 years (IQR 17-35). We could not identify clinical factors affecting the age at conversion; sex, BMI, insulin sensitivity or parental carrier status had no significant effect. However, for 1 SD unit increase of a polygenic risk score for type 2 diabetes, the predicted age at diagnosis decreased by 3.2 years. During the OGTT, the carriers had higher levels of plasma glucose and lower levels of serum insulin and C-peptide than the non-carriers. The carriers were also leaner than the non-carriers (by 5.0 kg, p=0.012, and by 2.1 kg/m(2) units of BMI, p=2.2 x 10(-4), using the first adult measurements) and, possibly as a result of insulin deficiency, demonstrated higher lipolytic activity (with medians of NEFA at fasting 621 vs 441 mu mol/l, p=0.0039; at 120 min during an OGTT 117 vs 64 mu mol/l, p=3.1 x 10(-5)). Conclusions/interpretation The most common causal variant of HNF1A-MODY, p.(Gly292fs), presents not only with hyperglycaemia and insulin deficiency, but also with increased lipolysis and markedly lower adult BMI. Serum insulin was more discriminative than C-peptide between carriers and non-carriers. A considerable proportion of carriers develop diabetes after young adulthood. Even among individuals with a monogenic form of diabetes, polygenic risk of diabetes modifies the age at onset of diabetes.Peer reviewe