Concept of essential hypertension in Ayurvedic perspectives

Essential hypertension is an instrumental disease which is the recent diagnostic invention of modern science. However there is no any reference which directly resembles with its pathophysiological views in Ayurvedic classics. Lots of works have been carried out on concept of hypertension to evaluate the perfect diagnosis and mode of treatment on the basis of Ayurvedic principles, but a widely acceptable theory is still not available. Different nomenclatures also have been adopted by Ayurvedic researchers like Rakta pradoshaj Vyadhi, Uchharaktachapa and Uchharaktabhara etc. on the basis of pathophysiology and symptoms of disease. Different diseases were considered parallels to hypertension such as; Raktagata Vata, Raktavrita Vata, Pranavrita Vyana, Vyanavrita Prana and Shleshmavrita Vyana etc. Ayurveda believe that pathophysiology of other diseases routes through hypertension. Keywords: Ayurveda, hypertension, Rakta pradoshaj Vyadhi, Raktagata Vata and Raktavrita Vata

Management of Grahani Roga by Ayurveda principles and life style modification

Grahani is an ayurveda terms related to the seat of agni (digestive fire), which help in the metabolism and digestion of food. The ancient text of ayurveda described that ingestion, digestion, absorption and assimilation of Aahaar is regulated by Grahani. When this Agni becomes; mandagni then improper digestion of ingested food leads pathological condition termed as Grahani roga. Similarly Trividh anomalies of the Jatharagni also termed as Grahanidosha. Grahani is a disease which affects large population globally especially in developing country and associated with improper food habits along with stressful lifestyle. The pathogenesis of Grahani roga works around Agnidosha which associated with impaired digestive function of digestive fire. Ayurveda described various treatment modalities for the management of Grahani roga such as; use of herbs & formulation, yoga and life style modification. Present article summarized ayurveda perspective of Grahani roga and its management by ayurveda principles and life style modification. Keywords: Ayurveda, Grahani, Agnidosha, Yoga, Life styl

Genome-Wide Association Study for Type 2 Diabetes in Indians Identifies a New Susceptibility Locus at 2q21

Indians undergoing socioeconomic and lifestyle transitions will be maximally affected by epidemic of type 2 diabetes (T2D). We conducted a two-stage genome-wide association study of T2D in 12,535 Indians, a less explored but high-risk group. We identified a new type 2 diabetes–associated locus at 2q21, with the lead signal being rs6723108 (odds ratio 1.31; P = 3.32 3 1029 ). Imputation analysis refined the signal to rs998451 (odds ratio 1.56; P = 6.3 3 10212) within TMEM163 that encodes a probable vesicular transporter in nerve terminals. TMEM163 variants also showed association with decreased fasting plasma insulin and homeostatic model assessment of insulin resistance, indicating a plausible effect through impaired insulin secretion. The 2q21 region also harbors RAB3GAP1 and ACMSD; those are involved in neurologic disorders. Forty-nine of 56 previously reported signals showed consistency in direction with similar effect sizes in Indians and previous studies, and 25 of them were also associated (P , 0.05). Known loci and the newly identified 2q21 locus altogether explained 7.65% variance in the risk of T2D in Indians. Our study suggests that common susceptibility variants for T2D are largely the same across populations, but also reveals a population-specific locus and provides further insights into genetic architecture and etiology of T2D

Religious / cultural imperatives to the environmental crisis and environmental ethics

Meeting: World Commission on Environment and Development, Public Hearing, 26-27 May 1986, Ottawa, ON, CARelated to DAP 87-4249 under which IDRC supported the WCED to acquire and duplicate original papers, submissions, tapes and transcripts, became the depository of all original archival materials and received the right to microfiche the collection for broader disseminatio

Perspectives on technology and development

Meeting: International Political Science Association Study Group on Technology and Development, Congress, 12th, 9-14 Aug. 1982, Rio de Janeiro, BRMeeting: World Congress of Political Science, 12th, 9-14 Aug. 1982, Rio de Janeiro, BRPreliminary draf

Perspectives on technology and development : papers prepared for the XIIth World Congress of Political Science ... Rio de Janeiro, Brazil, 9-14 Aug. 1982

Meeting: World Congress of Political Science, 12th, Study Group on Technology and Development, 9-14 Aug. 1982, Rio de Janeiro, BRPreliminary draf