Pengaruh Ekstrak Etanol Akar Ginseng Jawa Terhadap Tebal Lapisan CA1 Lamina Ptramidalis Hippocampus Tikus (Rattus Norvegicus)

ABSTRAK The effect of Ginseng Jawa root ethanol extract on the thickness of CA, pyramidal lamina of the hippocampus in rat (Rattus norvegicus) Background: Ginseng Jawa has similarity to Panax ginseng, which has been shown to increase the thickness of CA, pyramidal lamina of the hippocampus. Therefore, it is suspected that Ginseng Jawa may also have the similiar effect. Objective: To reveal the effect of ethanol extract of Ginseng Jawa root on the thickness of CA, hippocampus. Methods: Three month male rats {n=421, 150-200 g, were divided randomly into 6 groups, i.e. negative 1KN1,KN2) & positive (KP) control, 3 treatment (P1, P2, P3) group. Respectively, they were given aquadest (KN1}, 10% propylen glycol (KN2), 12 mg ethanol extract of Panax ginseng root/rat (KP) and 6.12 and 24 mg ethanol extract of Ginseng Jaws root/rat in 1 ml 10% propylen glycol solution(P1, P2, P3), orally, for 18 days. After rehearsal and eight-arm radial maze test, then the brains were collected for histological preparation, stained with 1% Blue Toluidin and the thickness were measured by using micrometer Results: The thickness (mm)of CA, hippocampus were 42.98±9.54 (KN1), 55±10.00 (KN2), 45.06±9.92(P1}, 57.26±15.00 (P2), 62.14±16.43 (P3) and 56.81 ±10.85 (KP). Conclusion: Ginseng Jawa root ethanol extract administered at 12 and 24 mg/rat dose has shown to increase significantly (