Researching Relationships between Truck Travel Time Performance Measures and On-Network and Off-Network Characteristics

Trucks serve significant amount of freight tonnage and are more susceptible to complex interactions with other vehicles in a traffic stream. While traffic congestion continues to be a significant ‘highway’ problem, delays in truck travel result in loss of revenue to the trucking companies. There is a significant research on the traffic congestion mitigation, but a very few studies focused on data exclusive to trucks. This research is aimed at a regional-level analysis of truck travel time data to identify roads for improving mobility and reducing congestion for truck traffic. The objectives of the research are to compute and evaluate the truck travel time performance measures (by time of the day and day of the week) and use selected truck travel time performance measures to examine their correlation with on-network and off-network characteristics. Truck travel time data for the year 2019 were obtained and processed at the link level for Mecklenburg County, Wake County, and Buncombe County, NC. Various truck travel time performance measures were computed by time of the day and day of the week. Pearson correlation coefficient analysis was performed to select the average travel time (ATT), planning time index (PTI), travel time index (TTI), and buffer time index (BTI) for further analysis. On-network characteristics such as the speed limit, reference speed, annual average daily traffic (AADT), and the number of through lanes were extracted for each link. Similarly, off-network characteristics such as land use and demographic data in the near vicinity of each selected link were captured using 0.25 miles and 0.50 miles as buffer widths. The relationships between the selected truck travel time performance measures and on-network and off-network characteristics were then analyzed using Pearson correlation coefficient analysis. The results indicate that urban areas, high-volume roads, and principal arterial roads are positively correlated with the truck travel time performance measures. Further, the presence of agricultural, light commercial, heavy commercial, light industrial, single-family residential, multi-family residential, office, transportation, and medical land uses increase the truck travel time performance measures (decrease the operational performance). The methodological approach and findings can be used in identifying potential areas to serve as truck priority zones and for planning decentralized delivery locations

Modeling and Predicting Geospatial Teen Crash Frequency

This research project 1) evaluates the effect of road network, demographic, and land use characteristics on road crashes involving teen drivers, and, 2) develops and compares the predictability of local and global regression models in estimating teen crash frequency. The team considered data for 201 spatially distributed road segments in Mecklenburg County, North Carolina, USA for the evaluation and obtained data related to teen crashes from the Highway Safety Information System (HSIS) database. The team extracted demographic and land use characteristics using two different buffer widths (0.25 miles and 0.5 miles) at each selected road segment, with the number of crashes on each road segment used as the dependent variable. The generalized linear models with negative binomial distribution (GLM-based NB model) as well as the geographically weighted negative binomial regression (GWNBR) and geographically weighted negative binomial regression model with global dispersion (GWNBRg) were developed and compared. This research relied on data for 147 geographically distributed road segments for modeling and data for 49 segments for validation. The annual average daily traffic (AADT), light commercial land use, light industrial land use, number of household units, and number of pupils enrolled in public or private high schools are significant explanatory variables influencing the teen crash frequency. Both methods have good predictive capabilities and can be used to estimate the teen crash frequency. However, the GWNBR and GWNBRg better capture the spatial dependency and spatial heterogeneity among road teen crashes and the associated risk factors

Risk Factors Associated with Crash Injury Severity Involving Trucks

Nearly 499,000 motor vehicle crashes involving trucks were reported across the United States in 2018, out of which 22% resulted in fatalities and injuries. Given the growing economy and demand for trucking in the future, it is crucial to identify the risk factors to understand where, when, and why the likelihood of getting involved in a severe or moderate injury crash with a truck is higher. This research, therefore, focuses on capturing and exploring risk factors associated with surrounding land use and demographic characteristics in addition to crash, driver, and on-network characteristics by modeling injury severity of crashes involving trucks. Crash data for Mecklenburg County in North Carolina from 2013 to 2017 was used to develop partial proportionality odds model and identify risk factors influencing injury severity of crashes involving trucks. The findings from this research indicate that dark lighting condition, inclement weather condition, the presence of double yellow or no-passing zone, road sections with speed limit \u3e40 mph and curves, and driver fatigue, impairment, and inattention have a significant influence on injury severity of crashes involving trucks. These outcomes indicate the need for effective geometric design and improved visibility to reduce the injury severity of crashes involving trucks. The likelihood of getting involved in a crash with a truck is also high in areas with high employment, government, light commercial, and light industrial land uses. The findings can be used to proactively plan and prioritize the allocation of resources to improve safety of transportation system users in these areas

In-stent thrombosis after 68 months of implantation inspite of continuous dual antiplatelet therapy: a case report

Lately, there has been an increased incidence of late stent thrombosis; especially following Drug eluting stent (DES) implantation. Several factors are associated with an increased risk of stent thrombosis, including the procedure itself, patient and lesion characteristics, stent design, and premature cessation of anti-platelet drugs. We present a case of late stent thrombosis (LST) following DES implantation after a period of 68 months, making it the longest reported case of LST reported in the literature, despite the use of dual anti-platelet therapy

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Modeling injury severity of crashes involving trucks: Capturing and exploring risk factors associated with land use and demographic in addition to crash, driver, and on-network characteristics

Nearly 499,000 motor vehicle crashes involving trucks were reported across the United States in 2018, out of which 22% resulted in fatalities and injuries. Given the growing economy and demand for trucking in the future, it is crucial to identify the risk factors to understand where and why the likelihood of getting involved in a severe or moderate injury crash with a truck is higher. The focus of this research, therefore, is on developing a methodology, capturing and integrating data, exploring, and identifying risk factors associated with surrounding land use and demographic characteristics in addition to crash, driver, and on-network characteristics by modeling injury severity of crashes involving trucks. Crash data for Mecklenburg County in North Carolina from 2013 to 2017 was used to develop partial proportional odds model and identify risk factors influencing injury severity of crashes involving trucks. The findings indicate that dark lighting condition, inclement weather condition, the presence of double yellow or no-passing zone, road sections with speed limit >40 mph and curves, and driver fatigue, impairment, and inattention have a significant influence on injury severity of crashes involving trucks. These outcomes indicate the need for effective geometric design and improved visibility to reduce the injury severity of crashes involving trucks. The likelihood of a severe or moderate injury crash involving a truck is also high in areas with high employment, government, light commercial, and light industrial land uses. The findings can be used to identify potential risk areas, proactively plan and prioritize the allocation of resources to improve safety of transportation system users in these areas

How accurate is the regional travel demand model in mimicking real-world travel times?

This paper provides insights pertaining to the validity of a regional travel demand model in mimicking real-world travel times. The estimated travel times from the regional travel demand model, for the base year 2015, for Mecklenburg County in the city of Charlotte, North Carolina (NC) were compared with travel time statistics from a private data source, for the same year. The results indicate that the estimated travel times from the regional travel demand model are typically lower than the 85th percentile travel times, irrespective of the link speed limit. The estimated travel times for the Central Business District (CBD) area type are moderately correlated with the travel time statistics from the private data source, irrespective of the time of the day. For all the other area types, stronger correlations were observed when the estimated travel times from the regional travel demand model are compared with 10th to 50th percentile travel times. The calculated Pearson correlation coefficients are low for morning and evening peak periods compared to mid-day and night-time period, indicating the inability of the regional travel demand model in mimicking congested traffic conditions accurately