Integration of ejectors into high-speed aircraft

The integration of ejectors into forebodies is considered for transonic and supersonic flight. Topics discussed include mixing flow in ducts, prediction of flow fields and external aerodynamics

Flow Rate of Solids in L-Valves

Movement of solids in a L-valve by fluid drag due to external aeration is opposed by frictional resistance at the wall/non-moving solids. Model equations developed for the threshold aeration rate and solids flow rate as a function of aeration rate compare well with the literature data

Nonlinear interactions isolated through scale synthesis in experimental wall turbulence

An experimental investigation of nonlinear scale interactions in a forced turbulent boundary layer is presented here. A dynamic wall perturbation mechanism was used to externally force two distinct large-scale synthetic modes with well-defined spatial and temporal wave numbers in a fully turbulent flow. The focus is on characterizing the nonlinear flow response at triadically consistent wave numbers that arises from the direct interactions of the two synthetic modes. These experimental results isolate triadic scale interactions in wall turbulence in a unique fashion, and provide the ability to explore the dynamics of scale coupling in a systematic and detailed manner. The ideas advanced here are intended to contribute towards modeling efforts of high-Reynolds-number wall turbulence

Small-scale phase organization through large-scale inputs in a turbulent boundary layer

A synthetic large-scale motion is excited in a flat plate turbulent boundary layer experiment and its influence on small-scale turbulence is studied. The synthetic scale is seen to alter the average natural phase relationships in a quasi-deterministic manner, and exhibit a phase-organizing influence on the directly coupled small-scales. The results and analysis presented here are of interest from a scientific perspective, and also suggest the possibility of engineering schemes for favorable manipulation of energetic small-scale turbulence through practical large-scale inputs

Researching Relationships between Truck Travel Time Performance Measures and On-Network and Off-Network Characteristics

Trucks serve significant amount of freight tonnage and are more susceptible to complex interactions with other vehicles in a traffic stream. While traffic congestion continues to be a significant ‘highway’ problem, delays in truck travel result in loss of revenue to the trucking companies. There is a significant research on the traffic congestion mitigation, but a very few studies focused on data exclusive to trucks. This research is aimed at a regional-level analysis of truck travel time data to identify roads for improving mobility and reducing congestion for truck traffic. The objectives of the research are to compute and evaluate the truck travel time performance measures (by time of the day and day of the week) and use selected truck travel time performance measures to examine their correlation with on-network and off-network characteristics. Truck travel time data for the year 2019 were obtained and processed at the link level for Mecklenburg County, Wake County, and Buncombe County, NC. Various truck travel time performance measures were computed by time of the day and day of the week. Pearson correlation coefficient analysis was performed to select the average travel time (ATT), planning time index (PTI), travel time index (TTI), and buffer time index (BTI) for further analysis. On-network characteristics such as the speed limit, reference speed, annual average daily traffic (AADT), and the number of through lanes were extracted for each link. Similarly, off-network characteristics such as land use and demographic data in the near vicinity of each selected link were captured using 0.25 miles and 0.50 miles as buffer widths. The relationships between the selected truck travel time performance measures and on-network and off-network characteristics were then analyzed using Pearson correlation coefficient analysis. The results indicate that urban areas, high-volume roads, and principal arterial roads are positively correlated with the truck travel time performance measures. Further, the presence of agricultural, light commercial, heavy commercial, light industrial, single-family residential, multi-family residential, office, transportation, and medical land uses increase the truck travel time performance measures (decrease the operational performance). The methodological approach and findings can be used in identifying potential areas to serve as truck priority zones and for planning decentralized delivery locations

Gene Conversion-Like Events in the Diversification of Human Rearranged IGHV3-23*01 Gene Sequences

Gene conversion (GCV), a mechanism mediated by activation-induced cytidine deaminase (AID) is well established as a mechanism of immunoglobulin diversification in a few species. However, definitive evidence of GCV-like events in human immunoglobulin genes is scarce. The lack of evidence of GCV in human rearranged immunoglobulin gene sequences is puzzling given the presence of highly similar germline donors and the presence of all the enzymatic machinery required for GCV. In this study, we undertook a computational analysis of rearranged IGHV3-23*01 gene sequences from common variable immunodeficiency (CVID) patients, AID-deficient patients, and healthy individuals to survey “GCV-like” activities. We analyzed rearranged IGHV3-23*01 gene sequences obtained from total PBMC RNA and single-cell polymerase chain reaction of individual B cell lysates. Our search identified strong evidence of GCV-like activity. We observed that GCV-like tracts are flanked by AID hotspot motifs. Structural modeling of IGHV3-23*01 gene sequence revealed that hypermutable bases flanking GCV-like tracts are in the single stranded DNA (ssDNA) of stable stem-loop structures (SLSs). ssDNA is inherently fragile and also an optimal target for AID. We speculate that GCV could have been initiated by the targeting of hypermutable bases in ssDNA state in stable SLSs, plausibly by AID. We have observed that the frequency of GCV-like events is significantly higher in rearranged IGHV3-23-*01 sequences from healthy individuals compared to that of CVID patients. We did not observe GCV-like events in rearranged IGHV3-23-*01 sequences from AID-deficient patients. GCV, unlike somatic hypermutation (SHM), can result in multiple base substitutions that can alter many amino acids. The extensive changes in antibody affinity by GCV-like events would be instrumental in protecting humans against pathogens that diversify their genome by antigenic shift

Strouhal number universality in high-speed cylinder wake flows

Flow oscillations in the near-wake region of a 2D circular cylinder are experimentally investigated at Mach 6 over the Reynolds number range $2.3\times10^5$ to $5\times10^5$. The oscillation frequency is obtained by spectral proper orthogonal decomposition of high-speed schlieren data. The Strouhal number based on the length of the near-wake shear layers is found to exhibit universal behavior. This corroborates experimental findings at Mach 4 from recent literature, and further, the universal behavior is also seen to hold with respect to Mach number. Time-resolved pressure measurements at the flow separation points on the cylinder aft surface show that coherent oscillatory activity occurs with a phase difference of $\pi$ radians between the two statistically-symmetric halves of the flow. This aspect of the flow dynamics at high speeds is in common with its low-speed counterpart, i.e. the canonical problem of cylinder wake in an incompressible flow.Comment: 5 pages, 6 figure