3 research outputs found
A Simple Approach for an Eggshell-Based 3D-Printed Osteoinductive Multiphasic Calcium Phosphate Scaffold
Natural
origin bioceramics are widely used for bone grafts. In the present
study, an eggshell-derived bioceramic scaffold is fabricated by 3D
printing as a potential bone-graft analogue. The eggshell, a biological
waste material, was mixed with a specific ratio of phosphoric acid
and chitosan to form a precursor toward the fabrication of an osteoinductive
multiphasic calcium phosphate scaffold via a coagulation-assisted
extrusion and sintering for a multiscalar hierarchical porous structure
with improved mechanical properties. Physicochemical characterization
of the formed scaffolds was carried out for phase analysis, surface
morphology, and mechanical properties. A similar scaffold was prepared
using a chemically synthesized calcium phosphate powder that was compared
with the natural origin one. The higher surface area associated with
the interconnected porosity along with multiple phases of the natural
origin scaffold facilitated higher cell adhesion and proliferation
compared to the chemically synthesized one. Further, the natural origin
scaffold displayed relatively higher cell differentiation activity,
as is evident by protein and gene expression studies. On subcutaneous
implantation for 30 days, promising vascular tissue in-growth was
observed, circumventing a major foreign body response. Collagen-rich
vascular extracellular matrix deposition and osteocalcin secretion
indicated bonelike tissue formation. Finally, the eggshell-derived
multiphasic calcium phosphate scaffold displayed improvement in the
mechanical properties with higher porosity and osteoinductivity compared
to the chemically derived apatite and unveiled a new paradigm for
utilization of biological wastes in bone-graft application
Abstracts of National Conference on Research and Developments in Material Processing, Modelling and Characterization 2020
This book presents the abstracts of the papers presented to the Online National Conference on Research and Developments in Material Processing, Modelling and Characterization 2020 (RDMPMC-2020) held on 26th and 27th August 2020 organized by the Department of Metallurgical and Materials Science in Association with the Department of Production and Industrial Engineering, National Institute of Technology Jamshedpur, Jharkhand, India.
Conference Title: National Conference on Research and Developments in Material Processing, Modelling and Characterization 2020Conference Acronym: RDMPMC-2020Conference Date: 26–27 August 2020Conference Location: Online (Virtual Mode)Conference Organizer: Department of Metallurgical and Materials Engineering, National Institute of Technology JamshedpurCo-organizer: Department of Production and Industrial Engineering, National Institute of Technology Jamshedpur, Jharkhand, IndiaConference Sponsor: TEQIP-