590 research outputs found
Transient hepatic attuenation differences and focal liver lesions:Sump effect due to primary arterial hyperperfusion
Penetrating particle ANalyzer (PAN)
PAN is a scientific instrument suitable for deep space and interplanetary
missions. It can precisely measure and monitor the flux, composition, and
direction of highly penetrating particles (100 MeV/nucleon) in deep
space, over at least one full solar cycle (~11 years). The science program of
PAN is multi- and cross-disciplinary, covering cosmic ray physics, solar
physics, space weather and space travel. PAN will fill an observation gap of
galactic cosmic rays in the GeV region, and provide precise information of the
spectrum, composition and emission time of energetic particle originated from
the Sun. The precise measurement and monitoring of the energetic particles is
also a unique contribution to space weather studies. PAN will map the flux and
composition of penetrating particles, which cannot be shielded effectively,
precisely and continuously, providing valuable input for the assessment of the
related health risk, and for the development of an adequate mitigation
strategy. PAN has the potential to become a standard on-board instrument for
deep space human travel.
PAN is based on the proven detection principle of a magnetic spectrometer,
but with novel layout and detection concept. It will adopt advanced particle
detection technologies and industrial processes optimized for deep space
application. The device will require limited mass (~20 kg) and power (~20 W)
budget. Dipole magnet sectors built from high field permanent magnet Halbach
arrays, instrumented in a modular fashion with high resolution silicon strip
detectors, allow to reach an energy resolution better than 10\% for nuclei from
H to Fe at 1 GeV/n
Analysis of conglutin seed storage proteins across lupin species using transcriptomic, protein and comparative genomic approaches
Background - The major proteins in lupin seeds are conglutins that have primary roles in supplying carbon, sulphur and nitrogen and energy for the germinating seedling. They fall into four families; α, β, γ and δ. Interest in these conglutins is growing as family members have been shown to have beneficial nutritional and pharmaceutical properties. Results - An in-depth transcriptome and draft genome from the narrow-leafed lupin (NLL; Lupinus angustifolius) variety, Tanjil, were examined and 16 conglutin genes were identified. Using RNAseq data sets, the structure and expression of these 16 conglutin genes were analysed across eight lupin varieties from five lupin species. Phylogenic analysis suggest that the α and γ conglutins diverged prior to lupin speciation while β and δ members diverged both prior and after speciation. A comparison of the expression of the 16 conglutin genes was performed, and in general the conglutin genes showed similar levels of RNA expression among varieties within species, but quite distinct expression patterns between lupin species. Antibodies were generated against the specific conglutin families and immunoblot analyses were used to compare the levels of conglutin proteins in various tissues and during different stages of seed development in NLL, Tanjil, confirming the expression in the seed. This analysis showed that the conglutins were expressed highly at the mature seed stage, in all lupin species, and a range of polypeptide sizes were observed for each conglutin family. Conclusions - This study has provided substantial information on the complexity of the four conglutin families in a range of lupin species in terms of their gene structure, phylogenetic relationships as well as their relative RNA and protein abundance during seed development. The results demonstrate that the majority of the heterogeneity of conglutin polypeptides is likely to arise from post-translational modification from a limited number of precursor polypeptides rather than a large number of different genes. Overall, the results demonstrate a high degree of plasticity for conglutin expression during seed development in different lupin species
Targeted next generation sequencing of breast implant-associated anaplastic large cell lymphoma reveals mutations in JAK/STAT signalling pathway genes, TP53 and DNMT3A
Can physical activity influence human gut microbiota composition independently of diet? A systematic review
Evidence suggests that physical activity (PA) influences the human gut microbiota composition, but its role is unclear because of dietary interference. The aim of this review is to clarify this issue from this new perspective in healthy individuals. Articles analyzing intestinal microbiota from fecal samples by 16S rRNA amplicon sequencing were selected by searching the electronic databases PubMed, Scopus, and Web of Science until December 2020. For each study, methodological quality was assessed, and results about microbiota biodiversity indices, phylum and genus composition, and information on PA and diet were considered. From 997 potentially relevant articles, 10 met the inclusion criteria and were analyzed. Five studies involved athletes, three were performed on active people classified on the basis of habitual PA level, and two among sedentary subjects undergoing exercise interventions. The majority of the studies reported higher variability and prevalence of the phylum Firmicutes (genera Ruminococcaceae or Fecalibacteria) in active compared to inactive individuals, especially in athletes. The assessment of diet as a possible confounder of PA/exercise effects was completed only in four studies. They reported a similar abundance of Lachnospiraceae, Paraprevotellaceae, Ruminococcaceae, and Veillonellaceae, which are involved in metabolic, protective, structural, and histological functions. Further studies are needed to confirm these findings
Internal alignment and position resolution of the silicon tracker of DAMPE determined with orbit data
The DArk Matter Particle Explorer (DAMPE) is a space-borne particle detector
designed to probe electrons and gamma-rays in the few GeV to 10 TeV energy
range, as well as cosmic-ray proton and nuclei components between 10 GeV and
100 TeV. The silicon-tungsten tracker-converter is a crucial component of
DAMPE. It allows the direction of incoming photons converting into
electron-positron pairs to be estimated, and the trajectory and charge (Z) of
cosmic-ray particles to be identified. It consists of 768 silicon micro-strip
sensors assembled in 6 double layers with a total active area of 6.6 m.
Silicon planes are interleaved with three layers of tungsten plates, resulting
in about one radiation length of material in the tracker. Internal alignment
parameters of the tracker have been determined on orbit, with non-showering
protons and helium nuclei. We describe the alignment procedure and present the
position resolution and alignment stability measurements
Correction to: High precision particle astrophysics as a new window on the universe with an Antimatter Large Acceptance Detector In Orbit (ALADInO)
High precision particle astrophysics as a new window on the universe with an Antimatter Large Acceptance Detector In Orbit (ALADInO)
The DArk Matter Particle Explorer mission
The DArk Matter Particle Explorer (DAMPE), one of the four scientific space
science missions within the framework of the Strategic Pioneer Program on Space
Science of the Chinese Academy of Sciences, is a general purpose high energy
cosmic-ray and gamma-ray observatory, which was successfully launched on
December 17th, 2015 from the Jiuquan Satellite Launch Center. The DAMPE
scientific objectives include the study of galactic cosmic rays up to
TeV and hundreds of TeV for electrons/gammas and nuclei respectively, and the
search for dark matter signatures in their spectra. In this paper we illustrate
the layout of the DAMPE instrument, and discuss the results of beam tests and
calibrations performed on ground. Finally we present the expected performance
in space and give an overview of the mission key scientific goals.Comment: 45 pages, including 29 figures and 6 tables. Published in Astropart.
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