Original Research By Young Twinkle Students (ORBYTS): Ephemeris Refinement of Transiting Exoplanets III

We report photometric follow-up observations of thirteen exoplanets (HATS-1 b, HATS-2 b, HATS-3 b, HAT-P-18 b, HAT-P-27 b, HAT-P-30 b, HAT-P-55 b, KELT-4A b, WASP-25 b, WASP-42 b, WASP-57 b, WASP-61 b and WASP-123 b), as part of the Original Research By Young Twinkle Students (ORBYTS) programme. All these planets are potentially viable targets for atmospheric characterisation and our data, which were taken using the LCOGT network of ground-based telescopes, will be combined with observations from other users of ExoClock to ensure that the transit times of these planets continue to be well-known, far into the future

Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes II: Optimisation of the PK profile

Optimisation of compounds from a series of deazaxanthines is described. SAR from the deazahypoxanthine series described previously was used to design improved deazaxanthine-based DPP-4 inhibitors which not only exhibited excellent activity and selectivity but showed improved in vivo activity due to an improved PK profile. Optimization of compound 1 resulted in the identification of compound 9i, which displayed good ex vivo DPP-4 inhibition and a superior PK profile in rat, potentially suitable for once daily dosing in man