Sonic levitation apparatus

A sonic levitation apparatus is disclosed which includes a sonic transducer which generates acoustical energy responsive to the level of an electrical amplifier. A duct communicates with an acoustical chamber to deliver an oscillatory motion of air to a plenum section which contains a collimated hole structure having a plurality of parallel orifices. The collimated hole structure converts the motion of the air to a pulsed. Unidirectional stream providing enough force to levitate a material specimen. Particular application to the production of microballoons in low gravity environment is discussed

Long-duration exercise at moderate work loads

Metabolic effects of long duration exercise at moderate work loads including tables of heart rate, rectal temperature, minute volume, water balance, and respiratory quotien

Investigating Heating and Cooling in the BCS & B55 Cluster Samples

We study clusters in the BCS cluster sample which are observed by Chandra and are more distant than redshift, z>0.1. We select from this subsample the clusters which have both a short central cooling time and a central temperature drop, and also those with a central radio source. Six of the clusters have clear bubbles near the centre. We calculate the heating by these bubbles and express it as the ratio r_heat/r_cool=1.34+/-0.20. This result is used to calculate the average size of bubbles expected in all clusters with central radio sources. In three cases the predicted bubble sizes approximately match the observed radio lobe dimensions. We combine this cluster sample with the B55 sample studied in earlier work to increase the total sample size and redshift range. This extended sample contains 71 clusters in the redshift range 0<z<0.4. The average distance out to which the bubbles offset the X-ray cooling in the combined sample is at least r_heat/r_cool=0.92+/-0.11. The distribution of central cooling times for the combined sample shows no clusters with clear bubbles and t_cool>1.2Gyr. An investigation of the evolution of cluster parameters within the redshift range of the combined samples does not show any clear variation with redshift.Comment: 12 pages, 9 figures, accepted for publication in MNRA

Intrabodies Binding the Proline-Rich Domains of Mutant Huntingtin Increase Its Turnover and Reduce Neurotoxicity

Although expanded polyglutamine (polyQ) repeats are inherently toxic, causing at least nine neurodegenerative diseases, the protein context determines which neurons are affected. The polyQ expansion that causes Huntington's disease (HD) is in the first exon (HDx-1) of huntingtin (Htt). However, other parts of the protein, including the 17 N-terminal amino acids and two proline (polyP) repeat domains, regulate the toxicity of mutant Htt. The role of the P-rich domain that is flanked by the polyP domains has not been explored. Using highly specific intracellular antibodies (intrabodies), we tested various epitopes for their roles in HDx-1 toxicity, aggregation, localization, and turnover. Three domains in the P-rich region (PRR) of HDx-1 are defined by intrabodies: MW7 binds the two polyP domains, and Happ1 and Happ3, two new intrabodies, bind the unique, P-rich epitope located between the two polyP epitopes. We find that the PRR-binding intrabodies, as well as VL12.3, which binds the N-terminal 17 aa, decrease the toxicity and aggregation of HDx-1, but they do so by different mechanisms. The PRR-binding intrabodies have no effect on Htt localization, but they cause a significant increase in the turnover rate of mutant Htt, which VL12.3 does not change. In contrast, expression of VL12.3 increases nuclear Htt. We propose that the PRR of mutant Htt regulates its stability, and that compromising this pathogenic epitope by intrabody binding represents a novel therapeutic strategy for treating HD. We also note that intrabody binding represents a powerful tool for determining the function of protein epitopes in living cells

Research in space commercialization, technology transfer, and communications, volume 2

Spectrum management, models for evaluating communication systems, the communications regulatory environment, expert prediction and consensus, remote sensing, and manned space operations research are discussed

Research in space commercialization, technology transfer and communications, vol. 2

Spectrum management, models for evaluating communications systems, and implications of communications regulations for NASA are considered as major parts of communications policy. Marketing LANDSAT products in developing countries, a political systems analysis of LANDSAT, and private financing and operation of the space operations center (space station) are discussed. Investment requirements, risks, government support, and other primary business and management considerations are examined

Automated Data Management Information System (ADMIS)

ADMIS stores and controls data and documents associated with manned space flight effort. System contains all data oriented toward a specific document; it is primary source of reports generated by the system. Each group of records is composed of one document record, one distribution record for each recipient of the document, and one summary record