Should Reading be a Core Class in Middle School?

This article discusses the value of reading as a core class in middle school. Research has shown that Language Arts, tasked with reading instruction, is insufficient for the development of the reading ability of middle students. Students are also expected to develop their reading skills through other core classes, such as Science, Social Studies, and Mathematics, but the development of reading ability is secondary in these classes. On the contrary, reading as a core class could improve reading achievement as it would be mandatory and provide all middle school students with explicit reading instruction by trained reading teachers

Constraining Isocurvature Initial Conditions with WMAP 3-year data

We present constraints on the presence of isocurvature modes from the temperature and polarization CMB spectrum data from the WMAP satellite alone, and in combination with other datasets including SDSS galaxy survey and SNLS supernovae. We find that the inclusion of polarization data allows the WMAP data alone, as well as in combination with complementary observations, to place improved limits on the contribution of CDM and neutrino density isocurvature components individually. With general correlations, the upper limits on these sub-dominant isocurvature components are reduced to ~60% of the first year WMAP results, with specific limits depending on the type of fluctuations. If multiple isocurvature components are allowed, however, we find that the data still allow a majority of the initial power to come from isocurvature modes. As well as providing general constraints we also consider their interpretation in light of specific theoretical models like the curvaton and double inflation.Comment: 8 pages, 7 figures. Revised Sec 4 and Figs 3-4 post-publication to correct an error for models with varying isocurvature spectral inde

The initial conditions of the universe: how much isocurvature is allowed?

We investigate the constraints imposed by the current data on correlated mixtures of adiabatic and non-adiabatic primordial perturbations. We discover subtle flat directions in parameter space that tolerate large (~60%) contributions of non-adiabatic fluctuations. In particular, larger values of the baryon density and a spectral tilt are allowed. The cancellations in the degenerate directions are explored and the role of priors elucidated.Comment: 4 pages, 4 figures. Submitted to PR

An Emerging Role for the Mammalian Target of Rapamycin in “Pathological” Protein Translation: Relevance to Cocaine Addiction

Complex neuroadaptations within key nodes of the brain’s “reward circuitry” are thought to underpin long-term vulnerability to relapse. A more comprehensive understanding of the molecular and cellular signaling events that subserve relapse vulnerability may lead to pharmacological treatments that could improve treatment outcomes for psychostimulant-addicted individuals. Recent advances in this regard include findings that drug-induced perturbations to neurotrophin, metabotropic glutamate receptor, and dopamine receptor signaling pathways perpetuate plasticity impairments at excitatory glutamatergic synapses on ventral tegmental area and nucleus accumbens neurons. In the context of addiction, much previous work, in terms of downstream effectors to these receptor systems, has centered on the extracellular-regulated MAP kinase signaling pathway. The purpose of the present review is to highlight the evidence of an emerging role for another downstream effector of these addiction-relevant receptor systems – the mammalian target of rapamycin complex 1 (mTORC1). mTORC1 functions to regulate synaptic protein translation and is a potential critical link in our understanding of the neurobiological processes that drive addiction and relapse behavior. The precise cellular and molecular changes that are regulated by mTORC1 and contribute to relapse vulnerability are only just coming to light. Therefore, we aim to highlight evidence that mTORC1 signaling may be dysregulated by drug exposure and that these changes may contribute to aberrant translation of synaptic proteins that appear critical to increased relapse vulnerability, including AMPARs. The importance of understanding the role of this signaling pathway in the development of addiction vulnerability is underscored by the fact that the mTORC1 inhibitor rapamycin reduces drug-seeking in pre-clinical models and preliminary evidence indicating that rapamycin suppresses drug craving in humans

The African Hospitalist Fellowship

The African Paediatric Fellowship Programme is rolling out a training course for newly qualified paediatricians to equip them with the leadership skills to function in complex general paediatric settings. The care of children in Africa carries its own unique demands, from the layering effects of multiple conditions through to establishing and sustaining services under severe resource constraints. This novel training concept aims to strengthen confidence and knowledge in areas that are not priorities during standard general paediatric training. The skills gained are considered of great relevance in assisting general paediatricians to achieve their full potential in their careers

Assumptions of the primordial spectrum and cosmological parameter estimation

The observables of the perturbed universe, CMB anisotropy and large structures, depend on a set of cosmological parameters, as well as, the assumed nature of primordial perturbations. In particular, the shape of the primordial power spectrum (PPS) is, at best, a well motivated assumption. It is known that the assumed functional form of the PPS in cosmological parameter estimation can affect the best fit parameters and their relative confidence limits. In this paper, we demonstrate that a specific assumed form actually drives the best fit parameters into distinct basins of likelihood in the space of cosmological parameters where the likelihood resists improvement via modifications to the PPS. The regions where considerably better likelihoods are obtained allowing free form PPS lie outside these basins. In the absence of a preferred model of inflation, this raises a concern that current cosmological parameters estimates are strongly prejudiced by the assumed form of PPS. Our results strongly motivate approaches toward simultaneous estimation of the cosmological parameters and the shape of the primordial spectrum from upcoming cosmological data. It is equally important for theorists to keep an open mind towards early universe scenarios that produce features in the PPS.Comment: 11 pages, 2 figures, discussions extended, main results unchanged, matches published versio

Constraints on isocurvature models from the WMAP first-year data

We investigate the constraints imposed by the first-year WMAP CMB data extended to higher multipole by data from ACBAR, BOOMERANG, CBI and the VSA and by the LSS data from the 2dF galaxy redshift survey on the possible amplitude of primordial isocurvature modes. A flat universe with CDM and Lambda is assumed, and the baryon, CDM (CI), and neutrino density (NID) and velocity (NIV) isocurvature modes are considered. Constraints on the allowed isocurvature contributions are established from the data for various combinations of the adiabatic mode and one, two, and three isocurvature modes, with intermode cross-correlations allowed. Since baryon and CDM isocurvature are observationally virtually indistinguishable, these modes are not considered separately. We find that when just a single isocurvature mode is added, the present data allows an isocurvature fraction as large as 13+-6, 7+-4, and 13+-7 percent for adiabatic plus the CI, NID, and NIV modes, respectively. When two isocurvature modes plus the adiabatic mode and cross-correlations are allowed, these percentages rise to 47+-16, 34+-12, and 44+-12 for the combinations CI+NID, CI+NIV, and NID+NIV, respectively. Finally, when all three isocurvature modes and cross-correlations are allowed, the admissible isocurvature fraction rises to 57+-9 per cent. The sensitivity of the results to the choice of prior probability distribution is examined.Comment: 20 pages, 24 figures. Submitted to PR

A Histological Assessment of the Mechanism of Early-Stage Healing of a Biphasic Calcium Phosphate in an \u3cem\u3eIn vivo\u3c/em\u3e Rabbit Model

The healing mechanism of osteoconductive biphasic calcium phosphate granules was investigated by a histological assessment of early-stage bone deposition and remodeling. The deposition of de novo bone on the scaffold granules was observed to initiate at the defect periphery by week one and in the bulk of the defect incorporating the granules by week four. New bone tissue was deposited in the space provided by the macroporosity and was observed in direct apposition to the implanted material confirming the bioactivity of the biphasic calcium phosphate. The granules were removed through a cell-mediated resorption process that was observed to begin as early as week two following surgery. Mature lamellar bone, fatty bone marrow, and vascularization was observed throughout the bulk of the defect with the cortical shell healed by week twelve. This healing mechanism was found to balance bone formation and implant resorption resulting in complete healing of the corticocancellous defect in the rabbit femoral condyle