An identification of the tolerable time-interleaved analog-to-digital converter timing mismatch level in high-speed orthogonal frequency division multiplexing systems

High-speed Terahertz communication systems has recently employed orthogonal frequency division multiplexing approach as it provides high spectral efficiency and avoids inter-symbol interference caused by dispersive channels. Such high-speed systems require extremely high-sampling time-interleaved analog-to-digital converters at the receiver. However, timing mismatch of time-interleaved analog-to-digital converters significantly causes system performance degradation. In this paper, to avoid such performance degradation induced by timing mismatch, we theoretically determine maximum tolerable mismatch levels for orthogonal frequency division multiplexing communication systems. To obtain these levels, we first propose an analytical method to derive the bit error rate formula for quadrature and pulse amplitude modulations in Rayleigh fading channels, assuming binary reflected gray code (BRGC) mapping. Further, from the derived bit error rate (BER) expressions, we reveal a threshold of timing mismatch level for which error floors produced by the mismatch will be smaller than a given BER. Simulation results demonstrate that if we preserve mismatch level smaller than 25% of this obtained threshold, the BER performance degradation is smaller than 0.5 dB as compared to the case without timing mismatch

HUMS2023 Data Challenge Result Submission

We implemented a simple method for early detection in this research. The implemented methods are plotting the given mat files and analyzing scalogram images generated by performing Continuous Wavelet Transform (CWT) on the samples. Also, finding the mean, standard deviation (STD), and peak-to-peak (P2P) values from each signal also helped detect faulty signs. We have implemented the autoregressive integrated moving average (ARIMA) method to track the progression.Comment: This report is being submitted as part of the Data Challenge organized by HUmS202

STREPTOCOCCUS INIAE, TÁC NHÂN GÂY BỆNH ?ĐEN THÂN? TRÊN CÁ RÔ ĐỒNG (ANABAS TESTUDINEUS)

Nghiên cứu mô tả lần đầu tiên phân lập vi khuẩn Streptococcus iniae là tác nhân gây bệnh ?đen thân? trên cá rô đồng (Anabas testudineus). Nghiên cứu đã thu được 114 mẫu cá rô đồng bệnh có dấu hiệu đen thân ở các ao nuôi thâm canh khác nhau ở các tỉnh đồng bằng sông Cửu Long. Cá bệnh có dấu hiệu khắp vùng lưng màu đen, mắt cá mờ đục, xuất huyết nội quan, gan, thận và tùy tạng sưng to. Các mẫu cá được kiểm tổng quát các tác nhân gây bệnh. Sau thời gian ủ 24-36 giờ ở 28°C, các khuẩn lạc thuần dạng nhỏ li ti, trắng đục được phân lập từ các mẫu gan, thận, tỳ tạng, máu, mắt và não cá bệnh xuất hiện nhiều trên môi trường brain heart infusion  agar (BHI ) và thạch máu (BA). Quan sát tế bào vi khuẩn nhuộm Gram có hình cầu, dạng chuỗi, Gram dương. Kết quả kiểm tra đặc điểm hình thái, sinh lý, sinh hóa, kít API 20Strep và giải trình tự gen 16S rRNA đã xác định vi khuẩn phân lập trên cá rô đồng bệnh ?đen thân? là Streptococcus iniae. Hai chủng vi khuẩn S. iniae điển hình được sử dụng để gây thí nghiệm cảm nhiễm trên cá rô đồng giống khỏe (trọng lượng 3-6 g) bằng phương pháp tiêm 4 nồng độ từ 103 đến 106 CFU/mL. ..

Assessing the efficacy and safety of magnesium sulfate for management of autonomic nervous system dysregulation in Vietnamese children with severe hand foot and mouth disease.

BACKGROUND: Brainstem encephalitis is a serious complication of hand foot and mouth disease (HFMD) in children. Autonomic nervous system (ANS) dysregulation and hypertension may occur, sometimes progressing to cardiopulmonary failure and death. Vietnamese national guidelines recommend use of milrinone if ANS dysregulation with Stage 2 hypertension develops. We wished to investigate whether magnesium sulfate (MgSO4) improved outcomes in children with HFMD if used earlier in the evolution of the ANS dysregulation (Stage 1 hypertension). METHODS: During a regional epidemic we conducted a randomized, double-blind, placebo-controlled trial of MgSO4 in children with HFMD, ANS dysregulation and Stage 1 hypertension, at the Hospital for Tropical Diseases in Ho Chi Minh city. Study participants received an infusion of MgSO4 or matched placebo for 72 h. We also reviewed data from non-trial HFMD patients in whom milrinone failed to control hypertension, some of whom received MgSO4 as second line therapy. The primary outcome for both analyses was a composite of disease progression within 72 h - addition of milrinone (trial participants only), need for ventilation, shock, or death. RESULTS: Between June 2014 and September 2016, 14 and 12 participants received MgSO4 or placebo respectively, before the trial was stopped due to futility. Among 45 non-trial cases with poorly controlled hypertension despite high-dose milrinone, 33 received MgSO4 while 12 did not. There were no statistically significant differences in the composite outcome between the MgSO4 and the placebo/control groups in either study (adjusted relative risk (95%CI) of [6/14 (43%) vs. 6/12 (50%)], 0.84 (0.37, 1.92), p = 0.682 in the trial and [1/33 (3%) vs. 2/12 (17%)], 0.16 (0.01, 1.79), p = 0.132 in the observational cohort). The incidence of adverse events was similar between the groups. Potentially toxic magnesium levels occurred very rarely with the infusion regime used. CONCLUSION: Although we could not demonstrate efficacy in these studies, there were no safety signals associated with use of 30-50 mg/kg/hr. MgSO4 in severe HFMD. Intermittent outbreaks of HFMD are likely to continue across the region, and an adequately powered trial is still needed to evaluate use of MgSO4 in controlling hypertension in severe HFMD, potentially involving a higher dose regimen. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01940250 (Registered 22 AUG 2013). Trial sponsor: University of Oxford

Kinetics of neutralizing antibodies against Omicron variant in Vietnamese healthcare workers after primary immunization with ChAdOx1-S and booster immunization with BNT162b2

We studied the development and persistence of neutralizing antibodies against SARS-CoV-2 ancestral strain, and Delta and Omicron (BA.1 and BA.2) variants in Vietnamese healthcare workers (HCWs) up to 15 weeks after booster vaccination. We included 47 HCWs, including group 1 (G1, N = 21) and group 2 (G2; N = 26) without and with breakthrough Delta variant infection before booster immunization, respectively). The study participants had completed primary immunization with ChAdOx1-S and booster vaccination with BNT162b2. Neutralizing antibodies were measured using a surrogate virus neutralization assay. Of the 21 study participants in G1, neutralizing antibodies against ancestral strain, Delta variant, BA.1, and BA.2 were (almost) abolished at month 8 after the second dose, but all had detectable neutralizing antibodies to the study viruses at week 2 post booster dose. Of the 26 study participants in G2, neutralizing antibody levels to BA.1 and BA.2 were significantly higher than those to the corresponding viruses measured at week 2 post breakthrough infection and before the booster dose. At week 15 post booster vaccination, neutralizing antibodies to BA.1 and BA.2 dropped significantly, with more profound changes observed in those without breakthrough Delta variant infection. Booster vaccination enhanced neutralizing activities against ancestral strain and Delta variant compared with those induced by primary vaccination. These responses were maintained at high levels for at least 15 weeks. Our findings emphasize the importance of the first booster dose in producing cross-neutralizing antibodies against Omicron variant. A second booster to maintain long-term vaccine effectiveness against the currently circulating variants merits further research

Spatiotemporal evolution of SARS-CoV-2 Alpha and Delta variants during large nationwide outbreak of COVID-19, Vietnam, 2021

We analyzed 1,303 SARS-CoV-2 whole-genome sequences from Vietnam, and found the Alpha and Delta variants were responsible for a large nationwide outbreak of COVID-19 in 2021. The Delta variant was confined to the AY.57 lineage and caused >1.7 million infections and >32,000 deaths. Viral transmission was strongly affected by nonpharmaceutical interventions

Wearable devices for remote monitoring of hospitalized patients with COVID-19 in Vietnam

Patients with severe COVID-19 disease require monitoring with pulse oximetry as a minimal requirement. In many low- and middle- income countries, this has been challenging due to lack of staff and equipment. Wearable pulse oximeters potentially offer an attractive means to address this need, due to their low cost, battery operability and capacity for remote monitoring. Between July and October 2021, Ho Chi Minh City experienced its first major wave of SARS-CoV-2 infection, leading to an unprecedented demand for monitoring in hospitalized patients. We assess the feasibility of a continuous remote monitoring system for patients with COVID-19 under these circumstances as we implemented 2 different systems using wearable pulse oximeter devices in a stepwise manner across 4 departments

Awareness and preparedness of healthcare workers against the first wave of the COVID-19 pandemic: A cross-sectional survey across 57 countries.

BACKGROUND: Since the COVID-19 pandemic began, there have been concerns related to the preparedness of healthcare workers (HCWs). This study aimed to describe the level of awareness and preparedness of hospital HCWs at the time of the first wave. METHODS: This multinational, multicenter, cross-sectional survey was conducted among hospital HCWs from February to May 2020. We used a hierarchical logistic regression multivariate analysis to adjust the influence of variables based on awareness and preparedness. We then used association rule mining to identify relationships between HCW confidence in handling suspected COVID-19 patients and prior COVID-19 case-management training. RESULTS: We surveyed 24,653 HCWs from 371 hospitals across 57 countries and received 17,302 responses from 70.2% HCWs overall. The median COVID-19 preparedness score was 11.0 (interquartile range [IQR] = 6.0-14.0) and the median awareness score was 29.6 (IQR = 26.6-32.6). HCWs at COVID-19 designated facilities with previous outbreak experience, or HCWs who were trained for dealing with the SARS-CoV-2 outbreak, had significantly higher levels of preparedness and awareness (p<0.001). Association rule mining suggests that nurses and doctors who had a 'great-extent-of-confidence' in handling suspected COVID-19 patients had participated in COVID-19 training courses. Male participants (mean difference = 0.34; 95% CI = 0.22, 0.46; p<0.001) and nurses (mean difference = 0.67; 95% CI = 0.53, 0.81; p<0.001) had higher preparedness scores compared to women participants and doctors. INTERPRETATION: There was an unsurprising high level of awareness and preparedness among HCWs who participated in COVID-19 training courses. However, disparity existed along the lines of gender and type of HCW. It is unknown whether the difference in COVID-19 preparedness that we detected early in the pandemic may have translated into disproportionate SARS-CoV-2 burden of disease by gender or HCW type