“Wrapping myself in cotton wool“: Australian women's experience of being diagnosed with vasa praevia

© 2014 Javid et al.; licensee BioMed Central Ltd. Background: Vasa praevia (VP) is an obstetric condition that is associated with significant perinatal mortality and morbidity. Although the incidence of VP is low, it is one of the few causes of perinatal death that can be potentially prevented through detection and appropriate care. The experience of women diagnosed with or suspected to have VP is largely unknown. The aim of this study was to explore the experiences and impact that a diagnosis or suspected diagnosis of VP had on a group of Australian women.Method: A qualitative study using a descriptive exploratory design was conducted and Australian women diagnosed with VP were recruited via online methods in 2012. An inductive approach was undertaken and interviews were analysed using the stages of thematic analysis. Results: Of the 14 women interviewed, 11 were diagnosed with VP during pregnancy with 5 subsequently found not to have VP (non-confirmed diagnosis). Three women were diagnosed during childbirth with one neonatal death. Five major themes were identified: feeling like a ticking time bomb; getting diagnosis right; being taken seriously; coping with inconsistent information; and, just a massive relief when it was all over.Conclusions: This is the first study to describe women's experience of being diagnosed with or suspected to have VP. The findings from this research reveal the dilemmas these women face even if their baby is ultimately born healthy. Their need for clear and consistent information, sensitive care, support and continuity is evident. Clinicians can use these findings in developing information, counselling and models of care for these women

Photometry of Proxima Centauri and Barnard's Star Using HST Fine Guidance Sensor 3: A Search for Periodic Variations

We have observed Proxima Centauri and Barnard's Star with Hubble Space Telescope Fine Guidance Sensor 3. Proxima Centauri exhibits small-amplitude, periodic photometric variations. Once several sources of systematic photometric error are corrected, we obtain 2 milli-magnitude internal photometric precision. We identify two distinct behavior modes over the past four years: higher amplitude, longer period; smaller amplitude, shorter period. Within the errors one period (P ~ 83d) is twice the other. Barnard's Star shows very weak evidence for periodicity on a timescale of approximately 130 days. If we interpret these periodic phenomena as rotational modulation of star spots, we identify three discrete spots on Proxima Cen and possibly one spot on Barnard's Star. We find that the disturbances change significantly on time scales as short as one rotation period.Comment: 39 pages, 17 figure

Interferometric Astrometry of Proxima Centauri and Barnard's Star Using Hubble Space Telescope Fine Guidance Sensor 3: Detection Limits for sub-Stellar Companions

We report on a sub-stellar companion search utilizing interferometric fringe-tracking astrometry acquired with Fine Guidance Sensor 3 (FGS 3) on the Hubble Space Telescope. Our targets were Proxima Centauri and Barnard's Star. We obtain absolute parallax values for Proxima Cen pi_{abs} = 0.7687 arcsecond and for Barnard's Star pi_{abs} = 0.5454 arcsecond. Once low-amplitude instrumental systematic errors are identified and removed, our companion detection sensitivity is less than or equal to one Jupiter mass for periods longer than 60 days for Proxima Cen. Between the astrometry and the radial velocity results we exclude all companions with M > 0.8M_{Jup} for the range of periods 1 < P < 1000 days. For Barnard's Star our companion detection sensitivity is less than or equal to one Jupiter mass for periods long er than 150 days. Our null results for Barnard's Star are consistent with those of Gatewood (1995).Comment: 35 pages, 13 figures, to appear in August 1999 A

ESG positioning in private infrastructure fundraising

This is the final version. Available on open access from Elsevier via the DOI in this recordData availability: The authors do not have permission to share data.We examine if environmental, social and governance (ESG) positioning by private equity infrastructure funds affects fundraising success. We use novel hand-collected data from a proprietary sample of fund marketing documents. By adapting methodologies from the extant literature on private equity fundraising, we directly address the fundraising event rather than the time between successor funds. Our results from private equity infrastructure fundraising events between 2006 and 2021 indicate that ESG positioning in fund marketing documents does not have a significant impact on fundraising success. This is an important finding as it suggests that investors do not respond to ESG-related claims in marketing materials at the fund level. However, there is some evidence of a weak positive relationship between ESG positioning and fundraising success that we observe in the earlier sample period that has dissipated in more recent years. This might be explained by firms trying to materialize value from “cheap-talk” due to first mover advantage

The Distance To The Hyades Cluster Based On Hubble Space Telescope Fine Guidance Sensor Parallaxes

Trigonometric parallax observations made with the Hubble Space Telescope (HST) Fine Guidance Sensor (FGS) 3 of seven Hyades members in six fields of view have been analyzed along with their proper motions to determine the distance to the cluster. Knowledge of the convergent point and mean proper motion of the Hyades is critical to the derivation of the distance to the center of the cluster. Depending on the choice of the proper-motion system, the derived cluster center distance varies by 9%. Adopting a reference distance of 46.1 pc or m - M = 3.32, which is derived from the ground-based parallaxes in the General Catalogue of Trigonometric Stellar Parallaxes (1995 edition), the FK5/PPM proper-motion system yields a distance 4% larger, while the Hanson system yields a distance 2% smaller. The HST FGS parallaxes reported here yield either a 14% or 5% larger distance, depending on the choice of the proper-motion system. Orbital parallaxes (Torres et al.) yield an average distance 4% larger than the reference distance. The variation in the distance derived from the HST data illustrates the importance of the proper-motion system and the individual proper motions to the derivation of the distance to the Hyades center; therefore, a full utilization of the HST FGS parallaxes awaits the establishment of an accurate and consistent proper-motion system.NASA HST GTO, HF-1042.01-93A, HF-1046.01-93A, NAS526555Astronom

Astrometry with Hubble Space Telescope: A Parallax of the Fundamental Distance Calibrator RR Lyrae

We present an absolute parallax and relative proper motion for the fundamental distance scale calibrator, RR Lyr. We obtain these with astrometric data from FGS 3, a white-light interferometer on HST. We find $\pi_{abs} = 3.82 \pm 0.2$ mas. Spectral classifications and VRIJHKT$_2$M and DDO51 photometry of the astrometric reference frame surrounding RR Lyr indicate that field extinction is low along this line of sight. We estimate =0.07\pm0.03 for these reference stars. The extinction suffered by RR Lyr becomes one of the dominant contributors to the uncertainty in its absolute magnitude. Adopting the average field absorption, =0.07 \pm 0.03, we obtain M_V^{RR} = 0.61 ^{-0.11}_{+0.10}. This provides a distance modulus for the LMC, m-M = 18.38 - 18.53^{-0.11}_{+0.10} with the average extinction-corrected magnitude of RR Lyr variables in the LMC, , remaining a significant uncertainty. We compare this result to more than 80 other determinations of the distance modulus of the LMC.Comment: Several typos corrected. To appear in The Astronomical Journal, January 200

The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukemia cells through downregulation of Mcl-1

The pro-survival Bcl-2 family member Mcl-1 is expressed in chronic lymphocytic leukemia (CLL), with high expression correlated with progressive disease. The spliceosome inhibitor spliceostatin A (SSA), is known to regulate Mcl-1 and so here we assessed the ability of SSA to elicit apoptosis in CLL. SSA induced apoptosis of CLL cells at low nanomolar concentrations in a dose- and time-dependent manner, but independently of SF3B1 mutational status, IGHV status and CD38 or ZAP70 expression. However, normal B and T cells were less sensitive than CLL cells (P=0.006 and P&lt;0.001, respectively). SSA altered the splicing of anti-apoptotic MCL-1L to MCL-1s in CLL cells coincident with induction of apoptosis. Overexpression studies in Ramos cells suggested Mcl-1 was important for SSA-induced killing since its expression inversely correlated with apoptosis (P=0.001). IL4 and CD40L, present in patient lymph nodes, are known to protect tumor cells from apoptosis and significantly inhibited SSA, ABT-263 and ABT-199 induced killing following administration to CLL cells (P=0.008). However, by combining SSA with the Bcl-2/Bcl-xL antagonists ABT-263 or ABT-199, we were able to overcome this pro-survival effect. We conclude that SSA combined with Bcl-2/Bcl-xL antagonists may have therapeutic utility for CL