Global Projections of Household Numbers Using Age Determined Ratios

A new method based upon age determined population ratios is described and used to estimate household population intensities (households per person). Using an additive and a bounded model household projections are given to 2050 for the world and to 2030 for seven fertility transition subgroups (cohorts) of the countries of the world. Based upon United Nations 2002 Revision data, from an estimated 1.56 billion households at 2000, household growth to 2030 is projected to be an additional 1.1 billion households, whether population increase is 1.3 billion persons under the United Nations low fertility variant or 2.7 billion persons under the high fertility variant. At that date over one third of all households are projected to be Chinese or Indian. By 2050 it is projected that there will be 3.3 billion households with a 95 per cent confidence interval on modelling error only of ± 0.5 billion. This compares with 3.2 billion in the Habitat: Global Report on Human Settlements 1996. The apparent similarity of total household growth under various scenarios conceals a wide range in the growth of household intensities across fertility transition cohorts. It is suggested that models, projections and error be reviewed biennially and that household and population projections be produced jointly.Household projections, world, age ratios, fertility

Shotgun Proteomics Identifies Serum Fibronectin as a Candidate Diagnostic Biomarker for Inclusion in Future Multiplex Tests for Ectopic Pregnancy

Ectopic pregnancy (EP) is difficult to diagnose early and accurately. Women often present at emergency departments in early pregnancy with a 'pregnancy of unknown location' (PUL), and diagnosis and exclusion of EP is challenging due to a lack of reliable biomarkers. The objective of this study was to identify novel diagnostic biomarkers for EP. Shotgun proteomics, incorporating combinatorial-ligand library pre-fractionation, was used to interrogate pooled sera (n = 40) from women undergoing surgery for EP, termination of viable intrauterine pregnancy and management of non-viable intrauterine pregnancy. Western blot was used to validate results in individual sera. ELISAs were developed to interrogate sera from women with PUL (n = 120). Sera were collected at time of first symptomatic presentation and categorized according to pregnancy outcome. The main outcome measures were differences between groups and area under the receiver operating curve (ROC). Proteomics identified six biomarker candidates. Western blot detected significant differences in levels of two of these candidates. ELISA of sera from second cohort revealed that these differences were only significant for one of these candidates, fibronectin. ROC analysis of ability of fibronectin to discriminate EP from other pregnancy outcomes suggested that fibronectin has diagnostic potential (ROC 0.6439; 95% CI 0.5090 to 0.7788; P>0.05), becoming significant when 'ambiguous' medically managed PUL excluded from analysis (ROC 0.6538; 95% CI 0.5158 to 0.7918; P<0.05). Fibronectin may make a useful adjunct to future multiplex EP diagnostic tests

TIME VS. GOODS: THE VALUE OF MEASURING HOUSEHOLD PRODUCTION TECHNOLOGIES

We take U.S. and Israeli household data on expenditures of time and goods, generate an exhaustive set of commodities that households produce/consume using them, and calculate their relative goods intensities. Leisure activities are uniformly relatively time intensive, health, travel and lodging relatively goods intensive. We demonstrate how education and age alter the goods intensity of household production. The results of this accounting can be used as guides to: understanding how goods and income taxation interact to affect welfare; expanding notions of the determinants of international flows of goods; generating models of business cycles and endogenous growth to include interactions of goods and time consumption; and obtaining better measures of the distribution of well being. Copyright 2006 Blackwell Publishing Ltd.