27 research outputs found
Experimental lagochilascariosis: histopathological study of inflammatory response to larval migration in the Murine model
Avaliação da eficácia terapêutica da ivermectina sobre larvas de quarto estádio de Lagochilascaris minor em gatos infectados experimentalmente
EVALUATION OF THE THERAPEUTIC EFFICACY OF LEVAMISOLE HYDROCHLORIDE ON THIRD-STAGE LARVAE OF Lagochilascaris minor IN EXPERIMENTALLY INFECTED MICE
Cryo-Microtome sections of coproculture larvae of Strongyloides stercoralis and Strongyloides ratti as antigen sources for the immunodiagnosis of human strongyloidiasis
Avaliação da eficácia terapêutica da ivermectina sobre larvas de quarto estádio de Lagochilascaris minor em gatos infectados experimentalmente
Avaliou-se a ação da ivermectina sobre larvas de quarto estádio em gatos infectados experimentalmente com Lagochilascaris minor. Foram utilizados 30 gatos (divididos, igualmente, em três grupos I, II e III), sendo que cada animal foi inoculado, por via oral, com 50 larvas de terceiro estádio do parasito. Cada animal, dos grupos I e II, foi tratado com ivermectina na dosagen de 200mig/kg, no quinto dia após o inóculo (DAI). Os animais do grupo I foram examinados, clinicamente, entre 30 e 40 dias e os do grupo II entre 180 e 190 dias sendo, em seguida, submetidos à necropsia. Os dez animais do grupo III, não foram tratados com a droga constituindo o grupo controle. Independentemente do período de observação, observou-se 100% de eficácia da droga, visto que houve total interrupção do ciclo biológico do parasito em todos animais tratados. Todos animais do grupo controle desenvolveram a infecção por Lagochilascaris minor
ASSESSMENT OF IVERMECTIN THERAPEUTIC EFFICACY ON THIRD-STAGE LARVAE OF Lagochilascaris minor IN MICE EXPERIMENTALLY INFECTED
In this study we evaluated the potential action of ivermectin on third-stage larvae, both at migratory and encysted phases, in mouse tissues after experimental infection with Lagochilascaris minor. Study groups I and II consisted of 120 mice that were orally administered 1,000 parasite eggs. In order to assess ivermectin action upon migratory larvae, group I (60 mice) was equally split in three subgroups, namely I-A, I-B, and I-C. On the 7th day after inoculation (DAI), each animal from the subgroup I-A was treated with 200 µg/Kg ivermectin while subgroup I-B was given 1,000 µg/Kg, both groups received a single subcutaneous dose. To assess the drug action on encysted larvae, group II was equally split in three subgroups, namely II-A, II-B, II-C. On the 45th DAI each animal was treated with ivermectin at 200 µg/Kg (subgroup II-A) and 1,000 µg/Kg (group II-B) with a single subcutaneous dose. Untreated animals of subgroups I-C and II-C were used as controls. On the 60th DAI all animals were submitted to larva search. At a dose of 1,000 µg/Kg the drug had 99.5% effectiveness on third-stage migratory larvae (subgroup I-B). Ivermectin efficacy was lower than 5% on third-stage encysted larvae for both doses as well as for migratory larvae treated with 200µg/Kg