1 research outputs found
Association between Several Persistent Organic Pollutants in Serum and Adipokine Levels in Breast Milk among Lactating Women of Korea
Exposure
to several persistent organic pollutants (POPs) has been
linked to alteration of lipid metabolism. Adipokines, such as leptin
and adiponectin, are hormones that play roles in lipid metabolism,
and have been suggested as markers of health effects that may lead
to obesity. To date, only serum adipokines have been associated with
POPs exposure. In the present study, for the first time, the associations
between leptin and adiponectin in breast milk, and several POPs in
serum were investigated among 82 lactating Korean women between 25
and 46 years of age. Breast milk adipokines are important because
adipokine intake of infant through breastfeeding may influence the
growth of infants. The median concentrations of leptin and adiponectin
in skimmed milk of the Korean lactating women were 17.9 ng/L and 16.5
μg/L, respectively. Leptin concentrations in breast milk were
negatively associated with ∑hexachlorohexane (HCH), oxychlordane,
∑chlordane, or 2,2′,4,4′,5,5′-hexachlorobiphenyl
(CB 153) levels in maternal serum. Linear relationships between adiponectin
and POPs concentrations were not observed, however, nonmonotonic relationship
which showed generally positive associations was suggested for <i>p</i>,<i>p</i>′-dichlorodiphenyltrichloroethane
(DDT) and ∑chlordane in quartile analysis. Our observations
show that POPs at the current level of exposure may be associated
with the alteration of lipid metabolism among lactating women. Implication
of adipokine transfer to breastfed infants is of concern and deserves
further investigation