Prevention of Ocular Scarring Post Glaucoma Filtration Surgery Using the Inflammatory Cell and Platelet Binding Modulator Saratin in a Rabbit Model

Clinical Relevance: Late complications can occur with use of current antimetabolites to prevent scarring following glaucoma filtration surgery (GFS). Safer, more targeted, anti-fibrosis agents are sought. Objectives: The protein saratin has been shown to exhibit anti-fibrotic and anti-thrombotic properties in response to injury, but had not been used for glaucoma surgery. The goal of this study was to compare the efficacy of saratin with that of the widely accepted mitomycin-C (MMC) in prolonging bleb survival following GFS in the rabbit model. Two saratin delivery routes were compared; a single intraoperative topical application versus a combination of intraoperative topical application with two additional postoperative injections. Methods: Twenty-four New Zealand White rabbits underwent GFS and received either intraoperative topical saratin, intraoperative topical saratin plus two injections on post-operative days 4 and 8, balanced saline solution (BSS), or MMC. The bleb tissues and their elevation durations were compared based on clinical and histological findings. Results: Rabbits receiving topical+injections of saratin had a mean bleb survival of 33.668.5 days, significantly higher than the negative BSS controls, which averaged 17.466.0 days (p = 0.018). No improvement over BSS was seen for rabbits receiving topical saratin only (15.564.8 days, p = 0.749). Rabbits receiving saratin did not develop bleb avascularity and thinning associated with MMC treatment and there were no apparent clinical signs of toxicity

Coordonner la Fête de la Science dans un réseau de médiathèque départementale

Pourquoi participer à la Fête de la Science en tant que bibliothèque de lecture publique au sein d’un réseau départemental ? La force du réseau Depuis 50 ans, la bibliothèque départementale de prêt (BDP) du Loiret s’emploie à dynamiser un réseau de bibliothèques communales et intercommunales, périmètre historique, auquel s’ajoute un réseau d’autres structures à géométrie variable (établissements liés à l’enfance, médico-sociaux, culturels, offices de tourisme…) avec lesquelles elle mène des a..

The Impact of Terrorism on the German Event Industry – An Empirical Study on Security Measures and Attendees’ Risk Perception

Events are a constant factor in daily life, fulfilling people with joy, experiences, and unforgettable memories. However, since the early 2000s, a major cloud lies over the festival and event industry. Multiple terror attacks, starting with the influential attack of the 11th of September 2001, shocked and unsettled the world. Terrorism evolved into a great threat, which triggered extensive changes in various fields, including the security sector as well as the event industry. Security measures had to be developed and reinforced, particularly on site of events as a result of multiple incidents at public events. The author researches the specific protection measures implemented and the risk perception of event attendees by using a mixed-methods approach. Findings reveal an increased awareness for terrorism and an intensification of security measures on the event organizer’s side. Event attendees have an enhanced risk perception towards terrorism and specific events, they attach importance to diverse security measures, but also admit that they negatively impact the event experience. Generally, they do not change their behavior concerning event attendance. As result of this research, the author was enabled to propose reasonable suggestions and recommendations for further research and the event and festival industry in general

Comment la science peut-elle contribuer plus significativement à la culture du risque des populations ?

International audienceEn France, de nombreuses études sur les risques naturels sont réalisées pour l’aménagement du territoire et la prévention, mais ces informations parviennent difficilement au citoyen ! Plusieurs exemples illustrent le fossé de connaissance qui sépare les scientifiques de la population concernée.En général des facteurs comme le caractère anxiogène des risques naturels, l'âge des individus, leur niveau d'éducation, la complexité ou l’attractivité des informations scientifiques, voire la lassitude sont invoqués pour expliquer cet écart. La multiplicité des acteurs et une possible déresponsabilisation de certains citoyens face aux conséquences des catastrophes peuvent aussi participer à cet écart.Pour informer et prévenir efficacement le public, les actions d’information doivent évoluer en tenant compte des éléments culturels (religion, croyances locales, …), en diffusant des connaissances simples et utiles sur les médias et les réseaux sociaux, en ne conservant qu’un minimum de science. Les autorités en charge des risques devront aussi affirmer leur leadership au travers d’exercices grandeur nature ou d’autres expériences participatives. La haute technologie développée dans les risques naturels peut aussi devenir un outil favorisant l’intérêt du public.Cette communication vise enfin à échanger sur les pratiques d’inventaire des risques naturels et leur communication auprès des populations concernées, entre les participants de ce 12ème Colloque sur les risques naturels au Québec