Оценка эффективности рециркуляционной технологии использования метанола при подготовке газа методом низкотемпературной сепарации

Объектом исследования является технология подготовки газа на Мыльджинском газоконденсатном месторождении. Цель данной работы – повышение эффективности использования метанола при подготовке газа методом низкотемпературной сепарации. С помощью моделирования в среде программы UniSim Design проведено исследование вариантов реализации рециркуляционной технологии использования метанола на УКПГ Мыльджинского месторождения. В результате исследования выявлено, что предлагаемый вариант рециркуляционной технологии позволяет сократить расход метанола на 110–140 кг/ч (40–45 %) за счет уменьшения уноса метанола с нестабильным конденсатом. Добавленная в технологическую схему установка ректификации метанола позволяет вернуть в технологический процесс еще 85–120 кг/ч метанола.The object of the study is the gas preparation technology at the Myldzhinskoye gas condensate field. The goal of this work is to increase the efficiency of methanol use in gas preparation by the low-temperature separation method. Using simulation in the UniSim Design program environment, a study was carried out on options for the implementation of the recirculation technology for the use of methanol at the gas treatment unit at the Myldzhinskoye field. As a result of the study, it was found that the proposed version of the recirculation technology reduces methanol consumption by 110–140 kg / h (40–45%) by reducing the entrainment of methanol with unstable condensate. The methanol rectification unit allows to return another 85–120 kg / h of methanol to the process

Synthetic lipopeptide Pam3CysSer(Lys)4 is an effective activator of human platelets

Lipopeptide analogues of the NH2-terminus of bacterial lipoprotein are known to induce activation of macrophages, neutrophils, and lymphocytes. We studied the effect of the lipopeptide N-palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-(R)-cysteinyl-( S)-seryl-(S)-lysyl-(S)-lysyl-(S)-lysyl-(S)-lysine [Pam3CysSer(Lys)4] on several functions of human platelets. Pam3CysSer(Lys)4 led to the aggregation of platelets and induced the secretion of serotonin with an effectiveness similar to thrombin. These cellular effects of Pam3CysSer(Lys)4 were concentration dependent, being half maximal at 2-3 microM and maximal at 10-30 microM. Another lipopeptide also induced platelet aggregation and serotonin secretion but was less potent and less effective than Pam3CysSer(Lys)4. The lipid moiety and the peptide moiety of Pam3CysSer(Lys)4 alone were without any effect. Lipopeptides also stimulated tyrosine phosphorylation of several proteins with molecular masses similar to those found to be tyrosine phosphorylated in response to thrombin, and Pam3CysSer(Lys)4 led to an increase in the cytosolic calcium concentration. All studied responses of platelets to lipopeptides were inhibited by the prostacyclin receptor agonist cicaprost. Taken together, our data show that lipopeptides are effective activators of human platelets and that this activation is susceptible to the action of physiological platelet inhibitors