39 research outputs found
ΠΡΠ΅Π½ΠΊΠ° ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠ΅ΡΠΈΡΠΊΡΠ»ΡΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΠΌΠ΅ΡΠ°Π½ΠΎΠ»Π° ΠΏΡΠΈ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠ΅ Π³Π°Π·Π° ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π½ΠΈΠ·ΠΊΠΎΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΠ½ΠΎΠΉ ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠΈ
ΠΠ±ΡΠ΅ΠΊΡΠΎΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ Π³Π°Π·Π° Π½Π° ΠΡΠ»ΡΠ΄ΠΆΠΈΠ½ΡΠΊΠΎΠΌ Π³Π°Π·ΠΎΠΊΠΎΠ½Π΄Π΅Π½ΡΠ°ΡΠ½ΠΎΠΌ ΠΌΠ΅ΡΡΠΎΡΠΎΠΆΠ΄Π΅Π½ΠΈΠΈ. Π¦Π΅Π»Ρ Π΄Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ β ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΠΌΠ΅ΡΠ°Π½ΠΎΠ»Π° ΠΏΡΠΈ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠ΅ Π³Π°Π·Π° ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π½ΠΈΠ·ΠΊΠΎΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΠ½ΠΎΠΉ ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠΈ.
Π‘ ΠΏΠΎΠΌΠΎΡΡΡ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π² ΡΡΠ΅Π΄Π΅ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ UniSim Design ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π²Π°ΡΠΈΠ°Π½ΡΠΎΠ² ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΡΠ΅ΡΠΈΡΠΊΡΠ»ΡΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΠΌΠ΅ΡΠ°Π½ΠΎΠ»Π° Π½Π° Π£ΠΠΠ ΠΡΠ»ΡΠ΄ΠΆΠΈΠ½ΡΠΊΠΎΠ³ΠΎ ΠΌΠ΅ΡΡΠΎΡΠΎΠΆΠ΄Π΅Π½ΠΈΡ. Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π²ΡΡΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΠΏΡΠ΅Π΄Π»Π°Π³Π°Π΅ΠΌΡΠΉ Π²Π°ΡΠΈΠ°Π½Ρ ΡΠ΅ΡΠΈΡΠΊΡΠ»ΡΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΡΠΎΠΊΡΠ°ΡΠΈΡΡ ΡΠ°ΡΡ
ΠΎΠ΄ ΠΌΠ΅ΡΠ°Π½ΠΎΠ»Π° Π½Π° 110β140 ΠΊΠ³/Ρ (40β45 %) Π·Π° ΡΡΠ΅Ρ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΡ ΡΠ½ΠΎΡΠ° ΠΌΠ΅ΡΠ°Π½ΠΎΠ»Π° Ρ Π½Π΅ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΡΠΌ ΠΊΠΎΠ½Π΄Π΅Π½ΡΠ°ΡΠΎΠΌ. ΠΠΎΠ±Π°Π²Π»Π΅Π½Π½Π°Ρ Π² ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΡΡ ΡΡ
Π΅ΠΌΡ ΡΡΡΠ°Π½ΠΎΠ²ΠΊΠ° ΡΠ΅ΠΊΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΌΠ΅ΡΠ°Π½ΠΎΠ»Π° ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ Π²Π΅ΡΠ½ΡΡΡ Π² ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΏΡΠΎΡΠ΅ΡΡ Π΅ΡΠ΅ 85β120 ΠΊΠ³/Ρ ΠΌΠ΅ΡΠ°Π½ΠΎΠ»Π°.The object of the study is the gas preparation technology at the Myldzhinskoye gas condensate field. The goal of this work is to increase the efficiency of methanol use in gas preparation by the low-temperature separation method. Using simulation in the UniSim Design program environment, a study was carried out on options for the implementation of the recirculation technology for the use of methanol at the gas treatment unit at the Myldzhinskoye field. As a result of the study, it was found that the proposed version of the recirculation technology reduces methanol consumption by 110β140 kg / h (40β45%) by reducing the entrainment of methanol with unstable condensate. The methanol rectification unit allows to return another 85β120 kg / h of methanol to the process
Synthetic lipopeptide Pam3CysSer(Lys)4 is an effective activator of human platelets
Lipopeptide analogues of the NH2-terminus of bacterial lipoprotein are known to induce activation of macrophages, neutrophils, and lymphocytes. We studied the effect of the lipopeptide N-palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-(R)-cysteinyl-( S)-seryl-(S)-lysyl-(S)-lysyl-(S)-lysyl-(S)-lysine [Pam3CysSer(Lys)4] on several functions of human platelets. Pam3CysSer(Lys)4 led to the aggregation of platelets and induced the secretion of serotonin with an effectiveness similar to thrombin. These cellular effects of Pam3CysSer(Lys)4 were concentration dependent, being half maximal at 2-3 microM and maximal at 10-30 microM. Another lipopeptide also induced platelet aggregation and serotonin secretion but was less potent and less effective than Pam3CysSer(Lys)4. The lipid moiety and the peptide moiety of Pam3CysSer(Lys)4 alone were without any effect. Lipopeptides also stimulated tyrosine phosphorylation of several proteins with molecular masses similar to those found to be tyrosine phosphorylated in response to thrombin, and Pam3CysSer(Lys)4 led to an increase in the cytosolic calcium concentration. All studied responses of platelets to lipopeptides were inhibited by the prostacyclin receptor agonist cicaprost. Taken together, our data show that lipopeptides are effective activators of human platelets and that this activation is susceptible to the action of physiological platelet inhibitors