Factors contributing to the time taken to consult with symptoms of lung cancer: a cross-sectional study

<b>Objectives</b>: To determine what factors are associated with the time people take to consult with symptoms of lung cancer, with a focus on those from rural and socially deprived areas. <b>Methods</b>: A cross-sectional quantitative interview survey was performed of 360 patients with newly diagnosed primary lung cancer in three Scottish hospitals (two in Glasgow, one in NE Scotland). Supplementary data were obtained from medical case notes. The main outcome measures were the number of days from (1) the date participant defined first symptom until date of presentation to a medical practitioner; and (2) the date of earliest symptom from a symptom checklist (derived from clinical guidelines) until date of presentation to a medical practitioner. <b>Results</b>: 179 participants (50%) had symptoms for more than 14 weeks before presenting to a medical practitioner (median 99 days; interquartile range 31–381). 270 participants (75%) had unrecognised symptoms of lung cancer. There were no significant differences in time taken to consult with symptoms of lung cancer between rural and/or deprived participants compared with urban and/or affluent participants. Factors independently associated with increased time before consulting about symptoms were living alone, a history of chronic obstructive pulmonary disease (COPD) and longer pack years of smoking. Haemoptysis, new onset of shortness of breath, cough and loss of appetite were significantly associated with earlier consulting, as were a history of chest infection and renal failure. <b>Conclusion</b>: For many people with lung cancer, regardless of location and socioeconomic status, the time between symptom onset and consultation was long enough to plausibly affect prognosis. Long-term smokers, those with COPD and/or those living alone are at particular risk of taking longer to consult with symptoms of lung cancer and practitioners should be alert to this

Multidimensional perfect fluid cosmology with stable compactified internal dimensions

Multidimensional cosmological models in the presence of a bare cosmological constant and a perfect fluid are investigated under dimensional reduction to 4-dimensional effective models. Stable compactification of the internal spaces is achieved for a special class of perfect fluids. The external space behaves in accordance with the standard Friedmann model. Necessary restrictions on the parameters of the models are found to ensure dynamical behavior of the external (our) universe in agreement with observations.Comment: 11 pages, Latex2e, uses IOP packages, submitted to Class.Quant.Gra

Supersymmetric geometries of IIA supergravity I

IIA supergravity backgrounds preserving one supersymmetry locally admit four types of Killing spinors distinguished by the orbits of $Spin(9,1)$ on the space of spinors. We solve the Killing spinor equations of IIA supergravity with and without cosmological constant for Killing spinors representing two of these orbits, with isotropy groups $Spin(7)$ and $Spin(7)\ltimes\mathbb{R}^8$. In both cases, we identify the geometry of spacetime and express the fluxes in terms of the geometry. We find that the geometric constraints of backgrounds with a $Spin(7)\ltimes\mathbb{R}^8$ invariant Killing spinor are identical to those found for heterotic backgrounds preserving one supersymmetry.Comment: 21 page

Invariant Killing spinors in 11D and type II supergravities

We present all isotropy groups and associated $\Sigma$ groups, up to discrete identifications of the component connected to the identity, of spinors of eleven-dimensional and type II supergravities. The $\Sigma$ groups are products of a Spin group and an R-symmetry group of a suitable lower dimensional supergravity theory. Using the case of SU(4)-invariant spinors as a paradigm, we demonstrate that the $\Sigma$ groups, and so the R-symmetry groups of lower-dimensional supergravity theories arising from compactifications, have disconnected components. These lead to discrete symmetry groups reminiscent of R-parity. We examine the role of disconnected components of the $\Sigma$ groups in the choice of Killing spinor representatives and in the context of compactifications.Comment: 22 pages, typos correcte

IIB solutions with N>28 Killing spinors are maximally supersymmetric

We show that all IIB supergravity backgrounds which admit more than 28 Killing spinors are maximally supersymmetric. In particular, we find that for all N>28 backgrounds the supercovariant curvature vanishes, and that the quotients of maximally supersymmetric backgrounds either preserve all 32 or N<29 supersymmetries.Comment: 27 page

Higher Structures in M-Theory

The key open problem of string theory remains its non-perturbative completion to M-theory. A decisive hint to its inner workings comes from numerous appearances of higher structures in the limits of M-theory that are already understood, such as higher degree flux fields and their dualities, or the higher algebraic structures governing closed string field theory. These are all controlled by the higher homotopy theory of derived categories, generalised cohomology theories, and $L_\infty$-algebras. This is the introductory chapter to the proceedings of the LMS/EPSRC Durham Symposium on Higher Structures in M-Theory. We first review higher structures as well as their motivation in string theory and beyond. Then we list the contributions in this volume, putting them into context.Comment: 22 pages, Introductory Article to Proceedings of LMS/EPSRC Durham Symposium Higher Structures in M-Theory, August 2018, references update

BPS preons and the AdS-M-algebra

We present here the AdS generalization of BPS preons, which were introduced as the hypothetical constituents of M-theory preserving all but one supersymmetries. Our construction, suggested by the relation of `lower dimensional preons' with higher spin theories, can be considered as a deformation of the M-algebraic description of the single supersymmetry broken by a preon, and provides another reason to identify the AdS generalization of the M-algebra, which we call the AdS-M-algebra, with osp(1|32).Comment: Plain latex, no figures, 19 pages minor corrections, one ref. added, as published in JHEP 04 (2008) 06

Parent Actions, Dualities and New Weyl-invariant Actions of Bosonic p-branes

By using the systematic approach of parent action method, we derive one Weyl-noninvariant and two Weyl-invariant actions of bosonic $p$-branes ($p\geq 2$) starting from the Nambu-Goto action, and establish the duality symmetries in this set of four actions. Moreover, we discover a new bosonic $p$-brane action (including the string theory) and deduce two corresponding Weyl-invariant formulations by proposing a new special parent action. We find that the same duality symmetries as those mentioned above exist in this new set of actions. The new $p$-brane actions are also briefly analyzed.Comment: 19 pages, 14 figures. The first section is modified slightly, and references are adde

N=31, D=11

We show that eleven-dimensional supergravity backgrounds with thirty one supersymmetries, N=31, admit an additional Killing spinor and so they are locally isometric to maximally supersymmetric ones. This rules out the existence of simply connected eleven-dimensional supergravity preons. We also show that N=15 solutions of type I supergravities are locally isometric to Minkowski spacetime.Comment: 17 page

Einstein and Brans-Dicke frames in multidimensional cosmology

Inhomogeneous multidimensional cosmological models with a higher dimensional space-time manifold M= M_0 x M_1 ...x M_n are investigated under dimensional reduction to a D_0-dimensional effective non-minimally coupled sigma-model which generalizes the familiar Brans-Dicke model. It is argued that the Einstein frame should be considered as the physical one. The general prescription for the Einstein frame reformulation of known solutions in the Brans-Dicke frame is given. As an example, the reformulation is demonstrated explicitly for the generalized Kasner solutions where it is shown that in the Einstein frame there are no solutions with inflation of the external space.Comment: 27 pages, Revte