22 research outputs found
Formation of Mono- and Bis-Michael Adducts by the Reaction of Nucleophilic Amino Acids with Hydroxymethylvinyl Ketone, a Reactive Metabolite of 1,3-Butadiene
No full textReaction of 1, 2, 3, 4-Diepoxybutane with 2-Deoxyguanosine: Initial Products and Their Stabilities and Decomposition Patterns under Physiological Conditions
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Characterization of 1, 2, 3, 4-Diepoxybutane-2-Deoxyguanosine Cross-Linking Products Formed at Physiological and Nonphysiological Conditions
No full textCharacterization of the Reaction Products of 2‘-Deoxyguanosine and 1,2,3,4-Diepoxybutane after Acid Hydrolysis: Formation of Novel Guanine and Pyrimidine Adducts
No full textCob(I)alamin for Trapping Butadiene Epoxides in Metabolism with Rat S9 and for Determining Associated Kinetic Parameters
No full textMethionine sulfoxide reductase A is a stereospecific methionine oxidase
No full textMethionine sulfoxide reductase A (MsrA) catalyzes the reduction of methionine sulfoxide to methionine and is specific for the S epimer of methionine sulfoxide. The enzyme participates in defense against oxidative stresses by reducing methionine sulfoxide residues in proteins back to methionine. Because oxidation of methionine residues is reversible, this covalent modification could also function as a mechanism for cellular regulation, provided there exists a stereospecific methionine oxidase. We show that MsrA itself is a stereospecific methionine oxidase, producing S-methionine sulfoxide as its product. MsrA catalyzes its own autooxidation as well as oxidation of free methionine and methionine residues in peptides and proteins. When functioning as a reductase, MsrA fully reverses the oxidations which it catalyzes
Formation of Fused-Ring 2′-Deoxycytidine Adducts from 1-Chloro-3-buten-2-one, an in Vitro 1,3-Butadiene Metabolite, under in Vitro Physiological Conditions
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