6 research outputs found
Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes.
- Author
- 6hman P
- Abbott L
- Acheatel R
- Adamkova V
- Adawi F
- Adler A
- Aguliera D
- Aizenberg D
- Akerblom A
- Akinboboye O
- Akpunonu B
- Al-Khatib S
- Alcocer Gamba MA
- Alexander K
- Alfonso L
- Almeida CA
- Alvarez L
- Alvarisqueta A
- Ambrish M
- Ambrosio G
- Amerena J
- Anastasi L
- Anderson H
- Andersone I
- Anekwe A
- Ang E
- Angelescu LM
- Angustias Quesada M
- Anoop M
- Aomar I
- Appel KF
- Arauz-Pacheco C
- Argoud G
- Arguelles I
- Armaganijan L
- Aron G
- Aronoff S
- Asamoah-Owusu NJ
- Athwal R
- Augusteniene A
- Azad N
- Azizad M
- Badat A
- Bain C
- Bajaj M
- Baldauf C
- Bandeira e Farias F
- Barbarash O
- Barber T
- Barkai L
- Baron M
- Barrientos Perez M
- Barros e Silva P
- Barros P
- Barsiene L
- Bartkowiak A Jr
- Bartolacci I
- Bashkin A
- Batit M
- Batra P
- Becker B
- Bell A
- Bellary S
- Bellido D
- Benjasuratwong Y
- Benson M
- Bental T
- Berenfus V
- Bergenstal R
- Berk M
- Bernacki G
- Bernandez S
- Bestermann W Jr
- Bethel MA
- Bezzegh K
- Bhargava A
- Bhatt B
- Bickel L
- Bieler T
- Biscoveanu M
- Bland V
- Blignaut S
- Bloomfield G
- Blumberg E
- Bobeva R
- Boenninghoff AH
- Boggs B
- Bondar I
- Borges J
- Botella Serrano M
- Botero Lopes R
- Botsyurko V
- Bourgeois R
- Braun M
- Bressler P
- Brychta T
- Buganova I
- Bundy C
- Busch K
- Busch R
- Buse JB
- Butnaru A
- Bybee K
- Cabrera Jardines R
- Calella P
- Calvert J
- Campbell C
- Canadas R
- Caponis J
- Carim-Ganey N
- Carr K
- Caterson I
- Catindig EA
- Cavale A
- Cavarape A
- Chacra A
- Chadha C
- Chan JC
- Chane M
- Chang A
- Chang A
- Chang M
- Chatterjee S
- Chaudhri O
- Cheah WK
- Chen JF
- Cheung BM
- Cheung S
- Cheung-Wong MM
- Choi J
- Choi KM
- Choi SH
- Chu DW
- Cignarelli M
- Clark J
- Clausen E
- Claxton E Jr
- Coetzee K
- Coetzer T
- Cohen J
- Coleman R
- Collier T
- Colman P
- Colquhoun D
- Constantinescu S
- Contreras Gilbert J
- Conway R
- Corder C
- Coronel Arroyo J
- Costa e Forti A
- Cox K
- Crawford V
- Crimmins D
- Cruciani A
- Cuddihy R
- Culman MI
- Cure Cure CA
- Custodio M
- Cutfield R
- Cylkowska B
- Czegany Z
- D\u2019Agostino R
- Damyanova V
- Dang C
- Danyte E
- Darbyshire J
- Dauber I
- Dauksiene D
- Davies M
- Davis C
- Dawson A
- Dayamani P
- De La Fuente RL
- De La Garza Hernandez NE
- de Salvo M
- De Souza Brito F
- de Valk HW
- Dean J
- del Prato S
- Delcourt C
- Deng H
- Denham D
- Denopol M
- Detweiler R
- DeVore A
- Dezso E
- Diamant M
- Diaz R
- DiGiovanna M
- Dimitropoulos I
- Distiller L
- Dixon P
- Dogadin S
- Dombrowski K
- Dong Y
- Donovan D
- Dreval A
- Dreval AV
- Drexel H
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- Dube F
- Duengen HD
- Dugano-Daphnis P
- Dulin M
- Dumas R
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- Dushkin H
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- Dzupina A
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- Ebrahim I
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- Eisen H
- El Shahawy M
- Elias N
- Eliaschewitz F
- Elkins M
- Elliott T
- Ellis G
- Erickson B
- Estevez R
- EXSCEL Study Group : Califf RM
- Farago K
- Farnsworth K
- Fasching P
- Fedacko J
- Feinglos M
- Felicio J
- Feng Y
- Ferch A
- Fern\ue1ndez Balsells M
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- Fushtey I
- Futo L
- G\uf3mez Cerezo F
- G\uf3mez Marcos MA
- Gaal Z
- Gagel R
- Gallegos JA
- Gandy W
- Gani M
- Garbelini B
- Garcia Ortiz L
- Garcia Puig J
- Garvey T
- Gaudiani L
- Gelersztein E
- Gellad Z
- Genovese S
- George D
- George J
- Ghani RA
- Giep S
- Gilbert J
- Gillies J
- Godbole N
- Godoy J
- Golden G
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- Gorelick F
- Gosselin G
- Gottlieb P
- Govender T
- Grabowska A
- Graur M
- Graves M
- Green JB
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- Greenspoon A
- Grishyna O
- Grueneberg M
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- Guo X
- Gushterova V
- Gustavson SM
- Gyrina O
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- Haque I
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- Jimenez A
- Jimeno C
- Johnson A
- Jones S
- Jordan D
- Julius U
- Junbo G
- Juskiene R
- K\uf6se V
- Kaczmarek G
- Kakariekiene V
- Kalen V
- Kamke W
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- Katona B
- Katz M
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- Parkhomenko O
- Pastare S
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- Tamez Perez HE
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- Wong YW
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- Wysham C
- Yakov A
- Yale JF
- Yale JF
- Yan BPY
- Yang CY
- Yang T
- Yeung VT
- Yong H
- Yoon KH
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- Zaharie DG
- Zaharieva S
- Zaidman C
- Zaluska R
- Zannad F
- Zazula A
- Zeitler E
- Zhang L
- Zhou S
- Zilahi Z
- Zimering M
- Zimmerman R
- Zinman B
- Zrahevskiy K
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Abstract
BACKGROUND:
The cardiovascular effects of adding once-weekly treatment with exenatide to usual care in patients with type 2 diabetes are unknown.
METHODS:
We randomly assigned patients with type 2 diabetes, with or without previous cardiovascular disease, to receive subcutaneous injections of extended-release exenatide at a dose of 2 mg or matching placebo once weekly. The primary composite outcome was the first occurrence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke. The coprimary hypotheses were that exenatide, administered once weekly, would be noninferior to placebo with respect to safety and superior to placebo with respect to efficacy.
RESULTS:
In all, 14,752 patients (of whom 10,782 [73.1%] had previous cardiovascular disease) were followed for a median of 3.2 years (interquartile range, 2.2 to 4.4). A primary composite outcome event occurred in 839 of 7356 patients (11.4%; 3.7 events per 100 person-years) in the exenatide group and in 905 of 7396 patients (12.2%; 4.0 events per 100 person-years) in the placebo group (hazard ratio, 0.91; 95% confidence interval [CI], 0.83 to 1.00), with the intention-to-treat analysis indicating that exenatide, administered once weekly, was noninferior to placebo with respect to safety (P<0.001 for noninferiority) but was not superior to placebo with respect to efficacy (P=0.06 for superiority). The rates of death from cardiovascular causes, fatal or nonfatal myocardial infarction, fatal or nonfatal stroke, hospitalization for heart failure, and hospitalization for acute coronary syndrome, and the incidence of acute pancreatitis, pancreatic cancer, medullary thyroid carcinoma, and serious adverse events did not differ significantly between the two groups.
CONCLUSIONS:
Among patients with type 2 diabetes with or without previous cardiovascular disease, the incidence of major adverse cardiovascular events did not differ significantly between patients who received exenatide and those who received placebo. (Funded by Amylin Pharmaceuticals; EXSCEL ClinicalTrials.gov number, NCT01144338 .)
Heart rate variability helps to identify patients with diastolic dysfunction prone to develop symptoms of heart failure
- Publication venue
- German Medical Science; Düsseldorf, Köln
- Publication date
- 08/02/2007
- Field of study
Prolongation of QTc and QRS but not the grade of diastolic dysfunction correlate with clinical severity of diastolic HF
- Publication venue
- German Medical Science; Düsseldorf, Köln
- Publication date
- 08/02/2007
- Field of study
The healthy core metabolism: A new paradigm for primary preventive nutrition
- Author
- A Fardet
- A Fardet
- A Fardet
- A Floegel
- A Floegel
- A Oberbach
- A Singh-Manoux
- A. Fardet
- AA Sayer
- BM Popkin
- C Pontoizeau
- DJY Ng
- DM Lloyd-Jones
- DP Jones
- E Fardet ARock
- E Luna-Heredia
- E Rapsomaniki
- E Trujillo
- Edmond Rock
- EG Armitage
- EJ Schaefer
- ES Ford
- ES Tai
- G Pannarale
- GJ Patti
- GX Xie
- HD Duengen
- I Rudkowska
- IKS Yap
- J van der Greef
- JB German
- JC Bast AHanekamp
- JC Hanekamp
- JE Ang
- JF Fries
- KW Schaie
- M Netzer
- MA Black
- MC Walsh
- ME Bollard
- ME Dumas
- MK Townsend
- PJ Brennan
- PX She
- R Chen
- RE Williams
- RF Heller
- RP Heaney
- S Primrose
- S Rezzi
- S Rezzi
- SC Kalhan
- Y Ni
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Ezetimibe added to statin therapy after acute coronary syndromes
- Author
- Aagnes I
- Aambakk MB
- Aase O
- Aaser E
- Abdel-Latief A
- Abell T
- Aboufakher R
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- Adamus J
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- Agocha A
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- Airaksinen J
- Airoldi F
- Aji J
- Akkad H
- Akubzanova E
- Al-Ani R
- Al-Jumaily J
- Alameda J
- Albirini A
- Albuquerque A
- Albuquerque D
- Alcasena S
- Alexander J
- Alfonso F
- Ali MI
- Alings MA
- Allall O
- Allen J
- Allen RP
- Allred S
- Almeira AS
- Alonso L
- Alsagheer S
- Alshaher M
- Altschuller A
- Alvarez J
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- Alvarez Y
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- Andrea B
- Andreou C
- Antonangelo A
- Antorrena I
- Appel K
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- Skjold ME
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- Skonieczny G
- Skovsbøl M
- Skowasch D
- Slipp S
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- The SH
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- Tuma P
- Tuohy E
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- Van Den Broeck D
- van der Bij P
- van der Sluis A
- van der Ven-Elzebroek N
- van der Weerdt A
- van der Zeijst M
- van der Zwaan C
- Van Dorpe A
- Van Dorpe A
- van Eck M
- van Es RF
- Van Hal JM
- van Hessen MW
- Van Kalmthout PM
- van Kempen LH
- Van Kieu C
- van Lennep HW
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- van Nes E
- van Rossum P
- van Ruijven I
- Van Vlies B
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- Vantomme C
- Varela P
- Varghese T
- Varma S
- Varner C
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- Vasiliauskas T
- Vazan A
- Vazquez A
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- Velle H
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- Vercauteren S
- Vertes G
- Vervoort G
- Veselka J
- Vestager KM
- Vetrano A
- Vicari R
- Vicente C
- Vicentini A
- Vichi V
- Viergever EP
- Vijay N
- Villa A
- Villa E
- Villa F
- Villani G
- Visconti L
- Viso M
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- Vizel S
- Vlastaris A
- Vogel C
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- Voitk J
- Voitk J
- Volpe M
- vom Dahl J
- Von Bakonyi A
- Vora K
- Voss J
- Voutilainen S
- Voyles W
- Vykoukalova T
- VĂ©rtes A
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- Waalewijn RA
- Wainstein M
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- Walters B
- Wang Y
- Wanitschek M
- Ward P
- Ward U
- Warlits B
- Warnica J
- Washam M
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- Watson R
- Wead J
- Wechselberger T
- Weeks A
- Weidinger F
- Weihs W
- Weil J
- Weiss A
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- Werter CJ
- Wertheimer J
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- Westecott B
- Westenburg J
- Wheeler M
- Wheeler M
- Whitaker T
- Whitcomb C
- White D
- White H
- White H
- White J
- White J
- White J
- White Jennifer A.
- Wiegman P
- Wiemer M
- Wikström P
- Wilhelm J
- Wilhelm M
- Wilks J
- Willems FF
- Williams P
- Williams S
- Williams V
- Wilson S
- Wilson V
- Wilson V
- Winestock J
- Winther-Friis B
- Wirtemburg P
- Wiseman A
- Withagen AJ
- Witsaman S
- Witt N
- Witzling V
- Wiviott Stephen D.
- Wohns D
- Wojciechowska C
- Wong A
- Wong B
- Wong G
- Wong S
- Wong Y
- Woodhead G
- Worner F
- Worthley S
- Wright L
- Wright T
- Wright W
- Wrzosek B
- Wu C
- Wu L
- Wu W
- Wyman P
- Yalcin R
- Yanez L
- Yedinak S
- Yeh H
- Yen M
- Yeo D
- Yigit Z
- Yildirir A
- Yildiz Z
- Yoon J
- Yoon M
- Young C
- Yovaniniz P
- Yu C
- Yu W
- Yuval R
- Zahn R
- Zakhary B
- Zaluska R
- Zambahari R
- Zanini R
- Zanini R
- Zanolin D
- Zapata M
- Zarandon R
- Zeiher A
- Zeltser D
- Zeman K
- Zemberova A
- Zemour G
- Zender H
- Zeymer U
- Zhukova Y
- Ziegler B
- Zimlichman R
- Zimmerman T
- Zimmermann R
- Zingarelli A
- Zirkle J
- Zucchetti C
- Zughaib M
- Zuidgeest JA
- Zuppiroli A
- Zwart PA
- Zweiker R
- Ă…ngman K
- Édes I
- Ă–stberg S
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2015
- Field of study
BACKGROUND: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. METHODS: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization ( 6530 days after randomization), or nonfatal stroke. The median follow-up was 6 years. RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (P<0.001). The Kaplan-Meier event rate for the primary end point at 7 years was 32.7% in the simvastatin-ezetimibe group, as compared with 34.7% in the simvastatin-monotherapy group (absolute risk difference, 2.0 percentage points; hazard ratio, 0.936; 95% confidence interval, 0.89 to 0.99; P = 0.016). Rates of pre-specified muscle, gallbladder, and hepatic adverse effects and cancer were similar in the two groups. CONCLUSIONS: When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit