7 research outputs found
Optical observations of NEA 3200 Phaethon (1983 TB) during the 2017 apparition
The near-Earth asteroid 3200 Phaethon (1983 TB) is an attractive object not
only from a scientific viewpoint but also because of JAXA's DESTINY+ target.
The rotational lightcurve and spin properties were investigated based on the
data obtained in the ground-based observation campaign of Phaethon. We aim to
refine the lightcurves and shape model of Phaethon using all available
lightcurve datasets obtained via optical observation, as well as our
time-series observation data from the 2017 apparition. Using eight 1-2-m
telescopes and an optical imager, we acquired the optical lightcurves and
derived the spin parameters of Phaethon. We applied the lightcurve inversion
method and SAGE algorithm to deduce the convex and non-convex shape model and
pole orientations. We analysed the optical lightcurve of Phaethon and derived a
synodic and a sidereal rotational period of 3.6039 h, with an axis ratio of a/b
= 1.07. The ecliptic longitude (lambda) and latitude (beta) of the pole
orientation were determined as (308, -52) and (322, -40) via two independent
methods. A non-convex model from the SAGE method, which exhibits a concavity
feature, is also presented.Comment: 14 pages, 4 figures, 1 figure in Appendix A. Accepted for publication
in Astronomy & Astrophysics (A&A
Polymorphisms within autophagy-related genes as susceptibility biomarkers for multiple myeloma: a meta-analysis of three large cohorts and functional characterization
Functional data used in this project have been meticulously catalogued and archived in the BBMRI-NL data infrastructure (https://hfgp.bbmri.nl/, accessed on 12 February 2020) using the MOLGENIS open-source platform for scientific data.Multiple myeloma (MM) arises following malignant proliferation of plasma cells in the
bone marrow, that secrete high amounts of specific monoclonal immunoglobulins or light chains,
resulting in the massive production of unfolded or misfolded proteins. Autophagy can have a
dual role in tumorigenesis, by eliminating these abnormal proteins to avoid cancer development,
but also ensuring MM cell survival and promoting resistance to treatments. To date no studies
have determined the impact of genetic variation in autophagy-related genes on MM risk. We
performed meta-analysis of germline genetic data on 234 autophagy-related genes from three independent study populations including 13,387 subjects of European ancestry (6863 MM patients and
6524 controls) and examined correlations of statistically significant single nucleotide polymorphisms
(SNPs; p < 1 Ă 10â9) with immune responses in whole blood, peripheral blood mononuclear
cells (PBMCs), and monocyte-derived macrophages (MDM) from a large population of healthy
donors from the Human Functional Genomic Project (HFGP). We identified SNPs in six loci, CD46,
IKBKE, PARK2, ULK4, ATG5, and CDKN2A associated with MM risk (p = 4.47 Ă 10â4â5.79 Ă 10â14).
Mechanistically, we found that the ULK4rs6599175 SNP correlated with circulating concentrations
of vitamin D3 (p = 4.0 Ă 10â4), whereas the IKBKErs17433804 SNP correlated with the number of
transitional CD24+CD38+ B cells (p = 4.8 Ă 10â4) and circulating serum concentrations of Monocyte
hemoattractant Protein (MCP)-2 (p = 3.6 Ă 10â4). We also found that the CD46rs1142469 SNP corre lated with numbers of CD19+ B cells, CD19+CD3â B cells, CD5+ IgDâ cells, IgMâ cells, IgDâIgMâ
cells, and CD4âCD8â PBMCs (p = 4.9 Ă 10â4â8.6 Ă 10â4
) and circulating concentrations of interleukin (IL)-20 (p = 0.00082). Finally, we observed that the CDKN2Ars2811710 SNP correlated with levels
of CD4+EMCD45RO+CD27â cells (p = 9.3 Ă 10â4
). These results suggest that genetic variants within
these six loci influence MM risk through the modulation of specific subsets of immune cells, as well
as vitamin D3â, MCP-2â, and IL20-dependent pathways.This work was supported by the European Unionâs Horizon 2020 research and innovation program, N° 856620 and by grants from the Instituto de Salud Carlos III and FEDER (Madrid, Spain; PI17/02256 and PI20/01845), ConsejerĂa de TransformaciĂłn EconĂłmica, Industria, Conocimiento y Universidades and FEDER (PY20/01282), from the CRIS foundation against cancer, from the Cancer Network of Excellence (RD12/10 Red de CĂĄncer), from the Dietmar Hopp Foundation and the German Ministry of Education and Science (BMBF: CLIOMMICS [01ZX1309]), and from National Cancer Institute of the National Institutes of Health under award numbers: R01CA186646, U01CA249955 (EEB).This work was also funded d by Portuguese National funds, through the Foundation for Science and Technology (FCT)âproject UIDB/50026/2020 and UIDP/50026/2020 and by the project NORTE-01-0145-FEDER-000055, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF)
The cosmic ray detector for the NICA collider
Multi-Purpose Detector (MPD) is a main part of a new Ion Collider fAcility (NICA) located in Dubna, Russia. To increase MPD functionality, it was proposed to add an additional muon trigger system for off-beam calibration of the MPD sub-detectors and for rejection of cosmic ray background during experiments. The system could also be very useful for astrophysical observations of cosmic showers initiated by high energy primary particles. This article describes the main goals of MCORD detector and the early stage of MCORD design, based on plastic scintillators with silicon photomultiplier photodetectors (SiPM) for scintillation readout and electronic system based on MicroTCA standard
The cosmic ray detector for the NICA collider
Multi-Purpose Detector (MPD) is a main part of a new Ion Collider fAcility (NICA) located in Dubna, Russia. To increase MPD functionality, it was proposed to add an additional muon trigger system for off-beam calibration of the MPD sub-detectors and for rejection of cosmic ray background during experiments. The system could also be very useful for astrophysical observations of cosmic showers initiated by high energy primary particles. This article describes the main goals of MCORD detector and the early stage of MCORD design, based on plastic scintillators with silicon photomultiplier photodetectors (SiPM) for scintillation readout and electronic system based on MicroTCA standard
Does a multiple myeloma polygenic risk score predict overall survival of myeloma patients?
Background: Genome-wide association studies (GWAS) of multiple myeloma in populations of European ancestry (EA) iden-tified and confirmed 24 susceptibility loci. For other cancers (e.g., colorectum and melanoma), risk loci have also been associated with patient survival Methods: We explored the possible association of all the known risk variants and their polygenic risk score (PRS) with multiple myeloma overall survival (OS) in multiple populations of EA [the International Multiple Myeloma rESEarch (IMMEnSE) consor-tium, the International Lymphoma Epidemiology consortium, CoMMpass, and the German GWAS] for a total of 3,748 multiple myeloma cases. Cox proportional hazards regression was used to assess the association between each risk SNP with OS under the allelic and codominant models of inheritance. All analyses were adjusted for age, sex, country of origin (for IMMEnSE) or principal components (for the others) and disease stage (ISS). SNP associa-tions were meta-analyzed. Results: SNP associations were meta-analyzed. From the meta-analysis, two multiple myeloma risk SNPs were associated with OS (P < 0.05), specifically POT1-AS1-rs2170352 [HR = 1.37; 95% confidence interval (CI) = 1.09-1.73; P = 0.007] and TNFRSF13B-rs4273077 (HR = 1.19; 95% CI = 1.01-1.41; P = 0.04). The association between the combined 24 SNP MM-PRS and OS, however, was not significant. Conclusions: Overall, our results did not support an association between the majority of multiple myeloma risk SNPs and OS. Impact: This is the first study to investigate the association between multiple myeloma PRS and OS in multiple myeloma