4 research outputs found
Antiproliferative activities of some 7-hydroxy-3-aryloxy-2-trifluoromethyl-4H-4-chromenone derivatives against 60 human cancer cell lines
234 derivatives of 7-hydroxy-3-aryloxy-2-trifluoromethyl-4H-4-chromenones were synthesized and tested for antitumor activity in vitro against human cancer cell lines in NCI (National Cancer Institute, USA) bioassay. It was shown high cytostatic and cytotoxic activity for the tested compounds 1-8 (GI50 3.44-41.1 mM and LC50 from 49.6 mM). The relationship between structures of the tested compounds and their antiproliferative activities is discussed.Π‘ΠΈΠ½ΡΠ΅Π·ΠΎΠ²Π°Π½ΠΎ 234 ΠΏΠΎΡ
ΡΠ΄Π½ΠΈΡ
7-Π³ΡΠ΄ΡΠΎΠΊΡΠΈ-3-Π°ΡΠΈΠ»ΠΎΠΊΡΠΈ-2-ΡΡΠΈΡΡΠΎΡΠΌΠ΅ΡΠΈΠ»-4Π-4-Ρ
ΡΠΎΠΌΠ΅Π½ΠΎΠ½Ρ ΡΠ° Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½ΠΎ ΡΡ
Π½Ρ ΠΏΡΠΎΡΠΈΡΠ°ΠΊΠΎΠ²Ρ Π°ΠΊΒΡΠΈΠ²Π½ΡΡΡΡ Π½Π° Π»ΡΠ½ΡΡΡ
ΡΠ°ΠΊΠΎΠ²ΠΈΡ
ΠΊΠ»ΡΡΠΈΠ½ Π»ΡΠ΄ΠΈΠ½ΠΈ Ρ ΠΠ°ΡΡΠΎΠ½Π°Π»ΡΠ½ΠΎΠΌΡ ΠΠ½ΡΡΠΈΡΡΡΡ Π Π°ΠΊΡ (Π‘Π¨Π). Π‘ΠΏΠΎΠ»ΡΠΊΠΈ 1β8 Π²ΠΈΡΠ²ΠΈΠ»ΠΈ Π²ΠΈΡΠΎΠΊΡ ΡΠΈΡΠΎΡΡΠ°ΡΠΈΡΠ½Ρ ΡΠ° ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ½Ρ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ (GI50 3,44β41,1 ΠΌΠΊΠ ΡΠ° LC50 Π²ΡΠ΄ 49,6 ΠΌΠΊΠ). ΠΠ±Π³ΠΎΠ²ΠΎΡΡΡΡΡΡΡ Π²Π·Π°ΡΠΌΠΎΠ·Π²'ΡΠ·ΠΎΠΊ ΠΌΡΠΆ ΡΡΡΡΠΊΡΡΡΠΎΡ ΡΠ΅ΡΡΠΎΠ²Π°Π½ΠΈΡ
ΡΠΏΠΎΠ»ΡΠΊ ΡΠ° ΡΡ
Π½ΡΠΎΡ ΠΏΡΠΎΠ»ΡΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΡ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ.Π‘ΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Ρ 234 ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ
7-Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈ-Π-Π°ΡΠΈΠ»ΠΎΠΊΡΠΈ-2-mpu-ΡΡΠΎΡΠΌΠ΅ΡΠΈΠ»-4Π-4-Ρ
ΡΠΎΠΌΠ΅Π½ΠΎΠ½Π° ΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π° ΠΈΡ
ΠΏΡΠΎΡΠΈΠ²ΠΎΡΠ°ΠΊΠΎΠ²Π°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π½Π° Π»ΠΈΠ½ΠΈΡΡ
ΡΠ°ΠΊΠΎΠ²ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Π² ΠΠ°ΡΠΈΠΎΠ½Π°Π»ΡΒΠ½ΠΎΠΌ ΠΠ½ΡΡΠΈΡΡΡΠ΅ Π Π°ΠΊΠ° (Π‘Π¨Π). Π‘ΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ 1β8 ΠΏΡΠΎΡΠ²ΠΈΠ»ΠΈ Π²ΡΡΠΎΠΊΡΡ ΡΠΈΡΠΎΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΡΡ ΠΈ ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ (Gl50 3,44β41,1 ΠΌΠΊΠ ΠΈ LC50 ΠΎΡ 49,6 ΠΌΠΊΠ). ΠΠ±ΡΡΠΆΠ΄Π°Π΅ΡΡΡ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·Ρ ΠΌΠ΅ΠΆΠ΄Ρ ΡΡΡΡΠΊΡΡΡΠΎΠΉ ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ ΠΈ ΠΈΡ
ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ
Antiproliferative activities of some 7-hydroxy-3-aryloxy-2-trifluoromethyl-4H-4-chromenone derivatives against 60 human cancer cell lines
234 derivatives of 7-hydroxy-3-aryloxy-2-trifluoromethyl-4H-4-chromenones were synthesized and tested for antitumor activity in vitro against human cancer cell lines in NCI (National Cancer Institute, USA) bioassay. It was shown high cytostatic and cytotoxic activity for the tested compounds 1-8 (GI50 3.44-41.1 mM and LC50 from 49.6 mM). The relationship between structures of the tested compounds and their antiproliferative activities is discussed.Π‘ΠΈΠ½ΡΠ΅Π·ΠΎΠ²Π°Π½ΠΎ 234 ΠΏΠΎΡ
ΡΠ΄Π½ΠΈΡ
7-Π³ΡΠ΄ΡΠΎΠΊΡΠΈ-3-Π°ΡΠΈΠ»ΠΎΠΊΡΠΈ-2-ΡΡΠΈΡΡΠΎΡΠΌΠ΅ΡΠΈΠ»-4Π-4-Ρ
ΡΠΎΠΌΠ΅Π½ΠΎΠ½Ρ ΡΠ° Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½ΠΎ ΡΡ
Π½Ρ ΠΏΡΠΎΡΠΈΡΠ°ΠΊΠΎΠ²Ρ Π°ΠΊΒΡΠΈΠ²Π½ΡΡΡΡ Π½Π° Π»ΡΠ½ΡΡΡ
ΡΠ°ΠΊΠΎΠ²ΠΈΡ
ΠΊΠ»ΡΡΠΈΠ½ Π»ΡΠ΄ΠΈΠ½ΠΈ Ρ ΠΠ°ΡΡΠΎΠ½Π°Π»ΡΠ½ΠΎΠΌΡ ΠΠ½ΡΡΠΈΡΡΡΡ Π Π°ΠΊΡ (Π‘Π¨Π). Π‘ΠΏΠΎΠ»ΡΠΊΠΈ 1β8 Π²ΠΈΡΠ²ΠΈΠ»ΠΈ Π²ΠΈΡΠΎΠΊΡ ΡΠΈΡΠΎΡΡΠ°ΡΠΈΡΠ½Ρ ΡΠ° ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ½Ρ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ (GI50 3,44β41,1 ΠΌΠΊΠ ΡΠ° LC50 Π²ΡΠ΄ 49,6 ΠΌΠΊΠ). ΠΠ±Π³ΠΎΠ²ΠΎΡΡΡΡΡΡΡ Π²Π·Π°ΡΠΌΠΎΠ·Π²'ΡΠ·ΠΎΠΊ ΠΌΡΠΆ ΡΡΡΡΠΊΡΡΡΠΎΡ ΡΠ΅ΡΡΠΎΠ²Π°Π½ΠΈΡ
ΡΠΏΠΎΠ»ΡΠΊ ΡΠ° ΡΡ
Π½ΡΠΎΡ ΠΏΡΠΎΠ»ΡΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΡ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ.Π‘ΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Ρ 234 ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ
7-Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈ-Π-Π°ΡΠΈΠ»ΠΎΠΊΡΠΈ-2-mpu-ΡΡΠΎΡΠΌΠ΅ΡΠΈΠ»-4Π-4-Ρ
ΡΠΎΠΌΠ΅Π½ΠΎΠ½Π° ΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π° ΠΈΡ
ΠΏΡΠΎΡΠΈΠ²ΠΎΡΠ°ΠΊΠΎΠ²Π°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π½Π° Π»ΠΈΠ½ΠΈΡΡ
ΡΠ°ΠΊΠΎΠ²ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Π² ΠΠ°ΡΠΈΠΎΠ½Π°Π»ΡΒΠ½ΠΎΠΌ ΠΠ½ΡΡΠΈΡΡΡΠ΅ Π Π°ΠΊΠ° (Π‘Π¨Π). Π‘ΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ 1β8 ΠΏΡΠΎΡΠ²ΠΈΠ»ΠΈ Π²ΡΡΠΎΠΊΡΡ ΡΠΈΡΠΎΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΡΡ ΠΈ ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ (Gl50 3,44β41,1 ΠΌΠΊΠ ΠΈ LC50 ΠΎΡ 49,6 ΠΌΠΊΠ). ΠΠ±ΡΡΠΆΠ΄Π°Π΅ΡΡΡ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·Ρ ΠΌΠ΅ΠΆΠ΄Ρ ΡΡΡΡΠΊΡΡΡΠΎΠΉ ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ ΠΈ ΠΈΡ
ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ
Automobile Media Discourse: Verbal Media Presentation of the Electric Cars
The article is devoted to a research of automobile media discourse. In the article lexical features of the English-speaking presentations of electric vehicles in mass media are distinguished. The concept "electric car / vehicle" is defined and the main ways of development of electric vehicles are considered. In the article advantages and shortcomings of electric cars in comparison with internal combustion engine vehicles in media presentations are disclosed. Structural and semantic features of the lexical presentation of electric vehicles in English-language media are revealed. The article demonstrates that the main lexical semantic, stylistic and grammatical features help the addresser in the media presentations of electrical cars to inform the addressee about goods, to form the positive image of the electric vehicles at the buyer and to induce to buy the electric car. The research contributes to the development of psycholinguistics, media linguistics, cultural linguistics, discourse theory and influence theory, automobile media linguistics on the example of verbal media presentations of electric cars / vehicals in English-speaking countries