A Microfluidic Approach to Investigate the Contact Force Needed for Successful Contact-Mediated Nucleation

Emulsions with crystalline dispersed phase fractions are becoming increasingly important in the pharmaceutical, chemical, and life science industries. They can be produced by using two-stage melt emulsification processes. The completeness of the crystallization step is of particular importance as it influences the properties, quality, and shelf life of the products. Subcooled, liquid droplets in agitated vessels may contact an already crystallized particle, leading to so-called contact-mediated nucleation (CMN). Energetically, CMN is a more favorable mechanism than spontaneous nucleation. The CMN happens regularly because melt emulsions are stirred during production and storage. It is assumed that three main factors influence the efficiency of CNM, those being collision frequency, contact time, and contact force. Not all contacts lead to successful nucleation of the liquid droplet, therefore, we used microfluidic experiments with inline measurements of the differential pressure to investigate the minimum contact force needed for successful nucleation. Numerical simulations were performed to support the experimental data obtained. We were able to show that the minimum contact force needed for CMN increases with increasing surfactant concentration in the aqueous phase

Experimental Investigation on Heat Transfer Enhancement with Passive Inserts in Flat Tubes in due Consideration of an Efficiency Assessment

This paper presents results of an experimental investigation on pressure drop and heat transfer for a wide range of Reynolds and Prandtl numbers ranging from 8 < Pr < 60 and 40 < Re < 3500, for flat tubes without and with passive inserts. For three different kinds of passive insert designs, the impact on heat and momentum transfer due to coaction of the total set of passive inserts with different shape and amount was investigated. Experimental results were analyzed regarding two main aspects: Heat transfer mechanisms and pressure drop induced by friction and form drag forces due to the presence of different shapes. After heat and momentum transfer mechanisms for each passive insert design were analyzed, heat transfer and pressure drop enhancement were compared to each other, leading to an efficiency discussion. Different concepts for efficiency evaluation, which are cited in literature, were applied to the presented experimental data. Pros and cons of the different concepts are discussed. Finally, we propose an equation for evaluation of total performance, which fully respects the energetic and exergetic aspects of heat transfer and pressure drop enhancement

A Microfluidic Approach to Investigate the Contact Force Needed for Successful Contact-Mediated Nucleation

Emulsions with crystalline dispersed phase fractions are becoming increasingly important in the pharmaceutical, chemical, and life science industries. They can be produced by using two-stage melt emulsification processes. The completeness of the crystallization step is of particular importance as it influences the properties, quality, and shelf life of the products. Subcooled, liquid droplets in agitated vessels may contact an already crystallized particle, leading to so-called contact-mediated nucleation (CMN). Energetically, CMN is a more favorable mechanism than spontaneous nucleation. The CMN happens regularly because melt emulsions are stirred during production and storage. It is assumed that three main factors influence the efficiency of CNM, those being collision frequency, contact time, and contact force. Not all contacts lead to successful nucleation of the liquid droplet, therefore, we used microfluidic experiments with inline measurements of the differential pressure to investigate the minimum contact force needed for successful nucleation. Numerical simulations were performed to support the experimental data obtained. We were able to show that the minimum contact force needed for CMN increases with increasing surfactant concentration in the aqueous phase

Experimental Investigation on Heat Transfer Enhancement with Passive Inserts in Flat Tubes in due Consideration of an Efficiency Assessment

This paper presents results of an experimental investigation on pressure drop and heat transfer for a wide range of Reynolds and Prandtl numbers ranging from 8 &lt; Pr &lt; 60 and 40 &lt; Re &lt; 3500, for flat tubes without and with passive inserts. For three different kinds of passive insert designs, the impact on heat and momentum transfer due to coaction of the total set of passive inserts with different shape and amount was investigated. Experimental results were analyzed regarding two main aspects: Heat transfer mechanisms and pressure drop induced by friction and form drag forces due to the presence of different shapes. After heat and momentum transfer mechanisms for each passive insert design were analyzed, heat transfer and pressure drop enhancement were compared to each other, leading to an efficiency discussion. Different concepts for efficiency evaluation, which are cited in literature, were applied to the presented experimental data. Pros and cons of the different concepts are discussed. Finally, we propose an equation for evaluation of total performance, which fully respects the energetic and exergetic aspects of heat transfer and pressure drop enhancement