768 research outputs found
Glass transition in self organizing cellular patterns
We have considered the dynamical evolution of cellular patterns controlled by
a stochastic Glauber process determined by the deviations of local cell
topology from that of a crystalline structure. Above a critical temperature
evolution is towards a common equilibrium state from any initial configuration,
but beneath this temperature there is a dynamical phase transition, with a
start from a quasi-random state leading to non-equilibrium glassy freezing
whereas an ordered start rests almost unchanged. A temporal persistence
function decays exponentially in the high temperature equilibrating state but
has a characteristic slow non-equilibrium aging-like behaviour in the low
temperature glassy phase.Comment: Added references, text minor change
Effect of short range order on electronic and magnetic properties of disordered Co based alloys
We here study electronic structure and magnetic properties of disordered CoPd
and CoPt alloys using Augmented Space Recursion technique coupled with the
tight-binding linearized muffin tin orbital (TB-LMTO) method. Effect of short
range ordering present in disordered phase of alloys on electronic and magnetic
properties has been discussed. We present results for magnetic moments, Curie
temperatures and electronic band energies with varying degrees of short range
order for different concentrations of Co and try to understand and compare the
magnetic properties and ordering phenomena in these systems.Comment: 15 pages,17 postscript figures,uses own style file
Towards precision medicine:What are the stratification hypotheses to identify homogeneous inflammatory subgroups
Diverse lines of research testify a link, presumably causal, between immune dysregulation and the development, course and clinical outcome of psychiatric disorders. However, there is a large heterogeneity among the patients? individual immune profile and this heterogeneity prevents the development of precise diagnostic tools and the identification of therapeutic targets. The aim of this review was to delineate possible subgroups of patients on the basis of clinical dimensions, investigating whether they could lead to particular immune signatures and tailored treatments. We discuss six clinical entry points; genetic liability to immune dysregula-tion, childhood maltreatment, metabolic syndrome, cognitive dysfunction, negative symptoms and treatment resistance. We describe the associated immune signature and outline the effects of anti-inflammatory drugs so far. Finally, we discuss advantages of this approach, challenges and future research directions. (c) 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/
The statistical analysis of a clinical trial when a protocol amendment changed the inclusion criteria
Abstract Background Sometimes, protocol amendments that change the inclusion and exclusion criteria are required in clinical trials. Then, the patient populations before and after the amendment may differ. Methods We propose to perform separate statistical tests for the different phases, i.e. for the patients recruited before and after the amendment, and to combine the tests using Fisher's combination test. After a significant combination test a multiple testing procedure can be applied to identify the phase(s) to which a proof of efficacy refers. We assume that the amendment(s) are not based on any type of unblinded data. The proposed method is investigated within a simulation study. Results The proposed combination approach is superior to the 'naïve' strategy to ignore the differences between the phases and pooling the data to perform just one statistical test. This superiority disappears when there are hardly any differences between the two phases. Conclusion When one or more protocol amendments change the inclusion and exclusion criteria, one should realize that the populations may differ. In this case, separate tests for the different phases together with a combination test are a powerful method that can be applied in a variety of settings. The (first) amendment should specify the combination test to be applied in order to combine the different phases.</p
Quasi-stationary regime of a branching random walk in presence of an absorbing wall
A branching random walk in presence of an absorbing wall moving at a constant
velocity undergoes a phase transition as the velocity of the wall
varies. Below the critical velocity , the population has a non-zero
survival probability and when the population survives its size grows
exponentially. We investigate the histories of the population conditioned on
having a single survivor at some final time . We study the quasi-stationary
regime for when is large. To do so, one can construct a modified
stochastic process which is equivalent to the original process conditioned on
having a single survivor at final time . We then use this construction to
show that the properties of the quasi-stationary regime are universal when
. We also solve exactly a simple version of the problem, the
exponential model, for which the study of the quasi-stationary regime can be
reduced to the analysis of a single one-dimensional map.Comment: 2 figures, minor corrections, one reference adde
PEG Branched Polymer for Functionalization of Nanomaterials with Ultralong Blood Circulation
Nanomaterials have been actively pursued for biological and medical
applications in recent years. Here, we report the synthesis of several new
poly(ethylene glycol) grafted branched-polymers for functionalization of
various nanomaterials including carbon nanotubes, gold nanoparticles (NP) and
gold nanorods (NRs), affording high aqueous solubility and stability for these
materials. We synthesize different surfactant polymers based upon
poly-(g-glutamic acid) (gPGA) and poly(maleic anhydride-alt-1-octadecene)
(PMHC18). We use the abundant free carboxylic acid groups of gPGA for attaching
lipophilic species such as pyrene or phospholipid, which bind to nanomaterials
via robust physisorption. Additionally, the remaining carboxylic acids on gPGA
or the amine-reactive anhydrides of PMHC18 are then PEGylated, providing
extended hydrophilic groups, affording polymeric amphiphiles. We show that
single-walled carbon nanotubes (SWNTs), Au NPs and NRs functionalized by the
polymers exhibit high stability in aqueous solutions at different pHs, at
elevated temperatures and in serum. Morever, the polymer-coated SWNTs exhibit
remarkably long blood circulation (t1/2 22.1 h) upon intravenous injection into
mice, far exceeding the previous record of 5.4 h. The ultra-long blood
circulation time suggests greatly delayed clearance of nanomaterials by the
reticuloendothelial system (RES) of mice, a highly desired property for in vivo
applications of nanomaterials, including imaging and drug delivery
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