226 research outputs found

    Global and Local Integrated Teaching Approaches for International MBA Programs: Marketing Management Perspectives

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    International MBA programs strive to develop better managers to deal with international experiences in the future. This paper aims at exploring how to cultivate and improve International MBA programs through the integration of global and local teaching-learning approaches. First, this paper explains why global and local integrated approaches are needed. Second, it analyzes how to integrate Western teaching with Eastern philosophical concepts, through the selection of textbooks, teaching practices, and learning processes

    Innovation outcomes of knowledge-seeking Chinese foreign direct investment

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    Purpose The purpose of this paper is to investigates how organizational learning, absorptive capacity, cultural integration, specialization of the acquired firm and characteristics of transferred knowledge impact innovation performance subsequent to overseas acquisitions. Design/methodology/approach Survey responses from 222 Chinese multinational enterprises engaged in overseas acquisitions. Findings Differences between acquiring and acquired firms’ capabilities, while having a positive direct influence, suppress the positive impact of organizational learning and absorptive capacity, suggesting that multinationals require some basic level of capabilities to appropriate value from overseas acquisitions. Research limitations/implications This paper investigates the impact of knowledge-seeking overseas acquisition of Chinese multinationals on innovation performance, as this appears to be the primary motive for making such acquisitions. Practical implications Knowledge-seeking overseas acquisition should be based upon the absorptive capacity of the acquiring firm and complementarity between both firms. In knowledge-seeking overseas acquisitions, establishing an effective organizational learning mechanism is necessary for improving innovation performance. Originality/value This paper reports on the behaviour and innovation performance of Chinese multinationals through analysis of primary data

    Provable Representation Learning for Imitation Learning via Bi-level Optimization

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    A common strategy in modern learning systems is to learn a representation that is useful for many tasks, a.k.a. representation learning. We study this strategy in the imitation learning setting for Markov decision processes (MDPs) where multiple experts' trajectories are available. We formulate representation learning as a bi-level optimization problem where the "outer" optimization tries to learn the joint representation and the "inner" optimization encodes the imitation learning setup and tries to learn task-specific parameters. We instantiate this framework for the imitation learning settings of behavior cloning and observation-alone. Theoretically, we show using our framework that representation learning can provide sample complexity benefits for imitation learning in both settings. We also provide proof-of-concept experiments to verify our theory.Comment: 26 page

    MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis

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    Cancer cell stemness (CCS) plays critical roles in both malignancy maintenance and metastasis, yet the underlying molecular mechanisms are far from complete. Although the importance of SOX2 in cancer development and CCS are well recognized, the role of MTA3 in these processes is unknown. In this study, we used esophageal squamous cell carcinoma (ESCC) as a model system to demonstrate that MTA3 can repress both CCS and metastasis in vitro and in vivo. Mechanistically, by forming a repressive complex with GATA3, MTA3 downregulates SOX2OT, subsequently suppresses the SOX2OT/SOX2 axis, and ultimately represses CCS and metastasis. More importantly, MTA

    MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis

    Get PDF
    Cancer cell stemness (CCS) plays critical roles in both malignancy maintenance and metastasis, yet the underlying molecular mechanisms are far from complete. Although the importance of SOX2 in cancer development and CCS are well recognized, the role of MTA3 in these processes is unknown. In this study, we used esophageal squamous cell carcinoma (ESCC) as a model system to demonstrate that MTA3 can repress both CCS and metastasis in vitro and in vivo. Mechanistically, by forming a repressive complex with GATA3, MTA3 downregulates SOX2OT, subsequently suppresses the SOX2OT/SOX2 axis, and ultimately represses CCS and metastasis. More importantly, MTA
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