Актуальні питання діяльності захисника під час екстрадиції (за матеріалами практики Європейського суду з прав людини)

Дроздов О. М. Актуальні питання діяльності захисника під час екстрадиції (за матеріалами практики Європейського суду з прав людини) / О. М. Дроздов // Традиції та новації юридичної науки: минуле, сучасність, майбутнє : матер. Міжнар. наук.-практ. конф. (м. Одеса, 19 трав. 2017 р.). У 2-х т. Т. 2 / відп. ред. Г. О. Ульянова. - Одеса : Видавничий дім "Гельветика", 2017. - С. 358-361

Changes in clinical and biochemical characteristics in combination treatment for diabetic macular edema

Background: Diabetic macular edema (DME) can be seen in both types of diabetic retinopathy (DR), and is a major cause of vision loss. Purpose: To evaluate the efficacy of the combination treatment for DME in type 2 diabetic patients with non-proliferative diabetic retinopathy (NPDR). Material and Methods: An open-label, controlled study included 45 type 2 diabetic patients with both NPDR and DME. Patients of the aflibercept-plus-hyperbaric oxygen (HBO) group and those of the aflibercept-only (control) group received a monthly intravitreous aflibercept at a dose of 2 mg (50 µL) for 3 months. In addition, the former patients received an adjunctive treatment with ten sessions of HBO in the period between the first and the third injections. Changes in clinical and biochemical characteristics were assessed at 3 months after initiation of treatment. Results: At 3 months, patients of the aflibercept-plus-HBO group showed a statistically significant improvement in visual acuity, improvement in retinal light sensitivity, reduction in manifestations of DME, and statistically significant reductions in blood glucose and glycated hemoglobin levels. At 3 months, the changes in the activities of antioxidant enzymes were more substantial in this group, and these improvements were statistically significant compared to baseline and compared to controls. Particularly, superoxide dismutase (SOD) activity, catalase (CAT) activity, and glutathione reductase (GSR) activity decreased by 33.9%, 22.4% and 17.7%, respectively, compared to baseline, and 34.78%, 28.9%, and 25.3%, respectively, compared to controls. Conclusion: Treatment for DME with the use of aflibercept and adjunctive HBO caused a substantial reduction in the frequency of DME and improvements in visual acuity and retinal light sensitivity in type 2 diabetic patients NPDR. Under these conditions, a decrease in the activity of CAT was larger than that of GSR but smaller than that of SOD, likely indicating an improvement in antioxidant protection

Влияние психотропных лекарственных средств на спонтанную поведенческую активность белых крыс

Установлено, что использование нейролептиков в условиях экспериментального психоза сопровождалось более выраженным, чем у интактных животных, понижением подвижности, опытнического поведения, эмоциональности. В отличие от этого, действие атипичного нейролептика сульпирида характеризовалось угнетением тревожности при повышении подвижности. Ноотропные препараты приводили к усилению подвижности и эмоциональной активности. Установлены фармакологические эффекты нейролептиков, антидепрессантов и ноотропных препаратов, которые могут применяться в клинической практике для оптимизации лечения больных с психическими расстройствами, в частности шизофренией

Logistic outsourcing in pharmacy. the theory and practice

Today, the introduction and application of a logistics approach to resource management allows pharmaceutical companies to increase their social, environmental and economic efficiency. The article is aimed to research the essence of the concept, types and party of logistic outsourcing in practical pharmacy. To reach the aimreview of foreign and domestic scientific sources and the existing legal framework of Ukraine on this issue have been analyzed. Investigation methods were bibliographic and analytical ones. The results of these studies indicate the today outsourcing is one of the main logistics strategies of domestic pharmaceutical companies, which is actively used in the sphere of IT-technologies and warehouse services. At the same time for ensuring high-quality providing outsourcing services, a legal and regulatory framework is needed that standardizes the interaction between firm customer and the outsourcer, also the development of standards for the provision of services of a certain type of outsourcing. Wide introduction of logistics outsourcing, as a modern form of optimization of logistics business processes, requires the formation of professional competence among future pharmacists in pharmaceutical logistics, its tools and strategies, i.e. training of competitive professionals capable of working in various directions of practical pharmacy. Introduction of the topic «Logistic outsourcing in practical pharmacy» in the educational process of students of pharmaceutical faculties (university), pharmacists-interns and pharmacists at the postgraduate level of training is necessary. It will improve the theoretical and practical training of future specialist pharmaceutists and will allow them to apply the knowledge which would be gained in the future in logistics outsourcing in the activities of pharmaceutical companies

On Nanomodification of Coating Obtained by Laser Cladding of Composite Powder 12NVK-01

The results of an experimental study of the effect of nanomodifying additives on the structure and mechanical properties of a multilayer coating during laser surfacing of a composite powder with a strengthening phase are presented. As a surfacing material, nickel powder 12NVK -01 with a strengthening phase of tungsten carbide was used, and as a modifying additive was a mixture of nanosized refractory powders of titanium nitride and yttrium oxide clad with iron and chromium. It is established that the deposited coating represents a complex system of phases formed during the melting and interaction of the chemical elements of the substrate and the melted powder mixture. The main component of the coating is the combination of nickel with iron and chromium of the type Ni3(Fe,Cr). In the melting process, a partial decomposition of the strengthening phase occurs, depending on the concentration of the nanomodifier. In the case considered, the optimum amount of the modifying additive providing the maximum hardness and wear resistance increase of the composite coatings of the Ni-Cr-B-Si-Fe / WC system is 0.1% by mass of the refractory TiN+Y[2]O[3] nanopowder additive in the composite material

On Nanomodification of Coating Obtained by Laser Cladding of Composite Powder 12NVK-01

The results of an experimental study of the effect of nanomodifying additives on the structure and mechanical properties of a multilayer coating during laser surfacing of a composite powder with a strengthening phase are presented. As a surfacing material, nickel powder 12NVK -01 with a strengthening phase of tungsten carbide was used, and as a modifying additive was a mixture of nanosized refractory powders of titanium nitride and yttrium oxide clad with iron and chromium. It is established that the deposited coating represents a complex system of phases formed during the melting and interaction of the chemical elements of the substrate and the melted powder mixture. The main component of the coating is the combination of nickel with iron and chromium of the type Ni3(Fe,Cr). In the melting process, a partial decomposition of the strengthening phase occurs, depending on the concentration of the nanomodifier. In the case considered, the optimum amount of the modifying additive providing the maximum hardness and wear resistance increase of the composite coatings of the Ni-Cr-B-Si-Fe / WC system is 0.1% by mass of the refractory TiN+Y[2]O[3] nanopowder additive in the composite material

Spin physics with antiprotons

New possibilities arising from the availability at GSI of antiproton beams, possibly polarised, are discussed. The investigation of the nucleon structure can be boosted by accessing in Drell-Yan processes experimental asymmetries related to cross-sections in which the parton distribution functions (PDF) only appear, without any contribution from fragmentation functions; such processes are not affected by the chiral suppression of the transversity function $h_1(x)$. Spin asymmetries in hyperon production and Single Spin Asymmetries are discussed as well, together with further items like electric and magnetic nucleonic form factors and open charm production. Counting rates estimations are provided for each physical case. The sketch of a possible experimental apparatus is proposed.Comment: Presented for the proceedings of ASI "Spin and Symmetry", Prague, July 5-10, 2004, to be published in Czech. J. Phys. 55 (2005

ЭКСПЕРИМЕНТАЛЬНАЯ ОЦЕНКА ВЛИЯНИЯ РАЗЛИЧНЫХ МАСЕЛ, ВХОДЯЩИХ В СОСТАВ АЛМАЗНОЙ СУСПЕНЗИИ, НА АДГЕЗИЮ ПОЛУЧАЕМОГО АЛМАЗОСОДЕРЖАЩЕГО ПОКРЫТИЯ К ПОВЕРХНОСТИ РАСПИЛОВОЧНОГО ДИСКА

The paper contains an experimental estimation of influence rate of various oil being included in diamond suspension on adhesion of the obtained diamond-containing coating to cutting disk surface  which is applied for working a mono-crystal diamond.Статья посвящена экспериментальной оценке степени влияния различных видов масел, входящих в состав алмазной суспензии, на адгезию получаемого алмазосодержащего покрытия к поверхности распиловочного диска, применяемого для обработки монокристаллов алмаза