The CMS Discovery Potential of Supersymmetry within mSugra with two same sign muons

A detailed study of the same-sign muon signature within the mSUGRA model was performed. Selection criteria based on the missing transverse energy in the events and the jet and muon transverse momenta are applied to select the data sample. An excess of SUSY events over the standard model background processes can be statistically significant for many benchmark points for an integrated luminosity of less than 10 fb/sup -1detailed detector simulation, trigger emulation and reconstruction were performed

Measuring Muon Reconstruction Efficiency from Data

We suggest a method of measuring the global muon reconstruction efficiency epsilon directly from data, which largely alleviates uncertainties associated with our ability to monitor and reproduce in Monte Carlo simulation all details of the underlying detector performance. With the data corresponding to an integrated luminosity L = 10 fb^-1, the precision of measuring epsilon for muons in the P_T range of 10-100~GeV will be better than 1%

SUSY Survey with Inclusive Muon and Same-Sign Dimuon Accompanied by Jets and MET with CMS

Generic signatures of supersymmetry with R-parity conservation include those of single isolated muons or like-sign isolated dimuon pairs, accompanied with energetic jets and missing transverse energy. The ability of CMS to discover supersymmetry with these signals is estimated for 10 fb^{-1} of data collected with the inclusive single-muon and dimuon High-Level-Trigger paths. The selection criteria are optimized and the systematic effects are studied for a single low-mass benchmark point of the constrained MSSM with m_0 = 60,GeV/c^2, m_{1/2} = 250,GeVc^2, tan beta=10, A_0=0 and mu> 0. Discovery contours in the m_0, m_{1/2}) plane are presented for integrated luminosities ranging from 1 to 100, fb^{-1}

Potential to Discover Supersymmetry in Events with Muons, Jets and Missing Energy in pp Collisions at s\sqrt{s} = 14 TeV with the CMS Detector

Generic signatures of supersymmetry with R-Parity conservation include those of single isolated muons or like-sign isolated dimuon pairs, accompanied with energetic jets and missing transverse energy. The ability of CMS to discover supersymmetry with these signals is estimated for 10 fb^-1 of collected data with the inclusive single- and di-muon High Level Trigger paths. The selection criteria are optimized and the systematic effects are studied for a single low-mass benchmark point of the constrained MSSM with m_0 = 60 GeV/c^2, m_1/2 = 250 GeV/c^2, tan beta = 10, A_0 = 0, and mu > 0. Discovery contours in the (m_0, m_1/2) plane are presented for integrated luminosities ranging from 1 to 100 fb^-1

Selection of Single Top Events with the CMS Detector at LHC

The detection of single-top events with CMS is discussed. Two selections are proposed, aimed to measure single top production in the Standard Model t- and s-channel, respectively. The perspectives of the measurements for an integrated luminosity of 10 fb-1 are described. The results are based on detailed detector simulations, either based on GEANT4, or on faster techniques. The reconstruction procedures developed by the CMS Collaboration are utilized

Experimental Determination of the Characteristics of a Positron Source Using Channeling

Numerical simulations and `proof of principle' experiments showed clearly the interest of using crystals as photon generators dedicated to intense positron sources for linear colliders. An experimental investigation, using a 10 GeV secondary electron beam, of the SPS-CERN, impinging on an axially oriented thick tungsten crystal, has been prepared and operated between May and August 2000. After a short recall on the main features of positron sources using channeling in oriented crystals, the experimental set-up is described. A particular emphasis is put on the positron detector made of a drift chamber, partially immersed in a magnetic field. The enhancement in photon and positron production in the aligned crystal have been observed in the energy range 5 to 40 GeV, for the incident electrons, in crystals of 4 and 8 mm as in an hybrid target. The first results concerning this experiment are presented hereafter.Comment: 3 pages, 6 figures, submitted to Linac200

STUDY OF THE PARAMETERS OF TOLERABILITY AND ADHERENCE TO THERAPY IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ARTERIAL HYPERTENSION ON THE BACKGROUND OF TREATMENT WITH FIXED COMBINATION OF RAMIPRIL AND AMLODIPINE (ACCORDING TO THE RESULTS OF OBSERVATIONAL STUDY "GRANAT-2")

Working group of the “GRANAT-2” study: Tula - Trubitsyn G.I., Ivanov Yu.V., Mirenkova O.K., Eskova R.A., Simonova R.P., Milon M.E., Telegina E.V., Kuznetsov A.M., Zhukova N.A., Zainullina I.K.; Rostov-on-Don - Budanov O.V., London E.M., Minosyan L.V., Nedashkovskaya N.G., Ter-Ananyants Ye.A.; Tomsk - Proskokova I.Yu., Permyakova O.V., Politova L.V., Maneeva I.D., Ivanova S.Yu.; Nizhny Novgorod - Larina O.V., Pokrovskaya I.N., Patselt E.A.; Moscow - Sladkova T.A., Zelenova Т.V. Aim. To study the tolerability and adherence to antihypertensive therapy in patients with hypertension and chronic obstructive pulmonary disease (COPD) using the fixed combination of ramipril and amlodipine in the observational program for patients with arterial hypertension and COPD (GRANAT-2). Material and methods. Patients with hypertension and COPD (n=52) with all inclusion criteria and without exclusion criteria who signed informed consent to participate in the GRANAT-2 program were included into the study. The use of a fixed combination of ramipril and amlodipine was recommended in all patients. The doses were determined by the treating physicians in accordance with the official drug instruction. The patients had 4 visits, and the duration of the study was 5 months. The Morisky-Green test was used to assess an adherence of patients to treatment. Assessments of blood pressure, adverse events were performed at all visits. Results. 50 of 52 patients completed the study: 45 patients used the studied fixed combination in the recommended doses, and 5 patients used other antihypertensive drugs, 2 patients withdrew from the study. Systolic blood pressure after 1 month of treatment decreased by an average of 20 mm Hg from the baseline, and diastolic blood pressure – by 10 mmHg. These rates after 5 months of therapy were 29 mm Hg and 15 mm Hg, respectively. Target blood pressure level was achieved in all patients. Increase in adherence of patients to treatment (according to the Morisky-Green test from 21.1% to 65.1%) was found. 2 cases of adverse events (dry cough) were registered. The discrepancy in adherence assessment was revealed between the results from the Morisky-Green test and the data from program case report forms. Conclusion. Regular patient visits to the doctor and the rapid achievement of an antihypertensive effect with good tolerability of a fixed combination of ramipril and amlodipine contributed to the increase in adherence of patients to treatment. Undesirable effects of the drug therapy are significant, but not leading factors that have a negative impact on the patient adherence to treatment

Behavioral risk factors and clinical course of cardiovascular diseases and other noncommunicable diseases during quarantine in various regions of Russia

Aim. To assess the behavioral risk factors and the clinical course of cardiovascular diseases (CVDs) and other noncommunicable diseases (NCDs) during quarantine in various regions of Russia.Material and methods. This multicenter cohort cross-sectional study included 205 men and women from 6 Russian cities. Further, 4 of them (Saransk, Nizhny Novgorod, Penza, Ulyanovsk) were combined into one group — the Volga region. The study included men and women aged 30-69 years with one or more NCDs (hypertension, coronary artery disease with or without myocardial infarction, type 2 diabetes, chronic obstructive pulmonary disease/asthma and cancer in patients receiving chemotherapy and/or radiation therapy) who were self-isolated during coronavirus disease 2019 (COVID-19) pandemic. For all patients, a questionnaire was used, which included socio-demographic parameters, behavioral risk factors, status of the underlying disease, incidence of COVID-19 and its complications. Self-assessment of the state of health was carried out using the European Quality of Life Questionnaire.Results. In every third Muscovite, the intensity of physical activity decreased, and in the groups of patients from Omsk and the Volga region, it was 45% and 43%, respectively. An increase in meal frequency and an impairment of eating habits in Moscow and Omsk was noted in 18,2% and 18,7% of participants, while in Volga region subjects, these parameters were 2 times higher (42,4%). At the same time, no significant changes of alcohol consumption and smoking was revealed in the cohorts. Hypertensive crises during a pandemic were noted in all three subgroups, but more of them were recorded in the Volga region — in every third patient (p< 0,05 compared to Moscow), in the Omsk group — in every fourth patient, and among Muscovites — no more than 5%. Clinical deterioration in patients with angina was noted in 15% of cases, while the smallest number was noted in Omsk subjects (5,3%), three times less than in other subgroups. Changes in intensity and regimen of hypoglycemic therapy were noted in patients from Omsk, while 30% of them (p< 0,05 compared with the Volga region) increased the doses of medications taken. Chronic obstructive pulmonary disease was registered in the group with the largest number of Volga region patients — 14,1% (p< 0,05 compared to Omsk), while 17% of patients in this group increased the dose of drugs. Any cancer was recorded in 13,6% of Muscovites, while in the other two groups — about 5%. The largest number of patients from the Volga region noted a health decline over the past year (30,8%), while every fifth patient from Omsk (19,6%) and 13,6% of Muscovites reported health changes.Conclusion. During quarantine and self-isolation, changes in dietary habits and physical activity decline were noted among patients with NCDs, while alcohol consumption and smoking remained practically unchanged. The change in clinical status was characterized by an increase in hypertensive crisis incidence, an increase in doses of antihypertensive and hypoglycemic medication. Depending on the region, the health decline was noted by 13-31% of patients with NCDs