Generic signatures of supersymmetry with R-Parity conservation include those of single isolated muons or like-sign isolated dimuon pairs, accompanied with energetic jets and missing transverse energy. The ability of CMS to discover supersymmetry with these signals is estimated for 10 fb^-1 of collected data with the inclusive single- and di-muon High Level Trigger paths. The selection criteria are optimized and the systematic effects are studied for a single low-mass benchmark point of the constrained MSSM with m_0 = 60 GeV/c^2, m_1/2 = 250 GeV/c^2, tan beta = 10, A_0 = 0, and mu > 0. Discovery contours in the (m_0, m_1/2) plane are presented for integrated luminosities ranging from 1 to 100 fb^-1