Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation : lesson from the nationwide study

Incidence and outcome of microbiologically documented bacterial/viral infections and invasive fungal disease (IFD) in children and adults after hematopoietic cell transplantation (HCT) were compared in 650 children and 3200 adults in multicenter cross-sectional nationwide study. Infections were diagnosed in 60.8% children and 35.0% adults, including respectively 69.1% and 63.5% allo-HCT, and 33.1% and 20.8% auto-HCT patients. The incidence of bacterial infections was higher in children (36.0% vs 27.6%; p  21 days were risk factors for death from infection. In conclusion, pediatric patients have 2.9-fold higher incidence and 2.5-fold better outcome of infections than adults after HCT

Clinical spectrum and outcome of invasive mucormycosis in children and adults: Polish experience of the decade 2010–2019

No epidemiological data exist so far on invasive mucormycosis (IM) in Polish hematopoietic cell transplantation (HCT) and pediatric hemato-oncology (PHO) centers. The objective of this study was to analyze the incidence, clinical course, therapy, and outcome of IM in pediatric and adult patients undergoing HCT and children with hemato-oncological diseases in Poland. A total number of 12425 at-risk patients were retrospectively analyzed, and the period between 2010 and 2019 was included. Patients were analyzed in three groups: nontransplant children with malignancies, children undergoing HCT, and adults after HCT. Twenty-one patients were diagnosed with IM, including 15 children (10 non-HCT, 5 HCT) and 6 HCT adults. Proven IM was confirmed in 18 patients, probable in 2 patients, and possible in 1 patient. Proven IM was diagnosed in 7.1% of all patients with invasive fungal diseases (IFDs), including 8.1% among PHO patients, 5.4% among pediatric HCT patients, and 7.0% among adult HCT patients. Clinically, pneumonia was diagnosed in 10 (47.6%) patients, involvement of the paranasal sinuses was found in 3 (14.3%) patients, gastrointestinal disease was noted in 2 (9.5%) patients, and disseminated mucormycosis was found in 6 (28.6%) patients. The probability of overall survival in IM patients was 0.50 ± 0.11. Infection-related mortality (IRM) was 10% for pediatric nontransplant IM patients and 82% for transplant IM (pediatric + adult) patients ( = 0.004). Among the transplant patients, all adults died within 120 days. IRM for pediatric HCT patients was 60% ( = 0.038). The only prognostic factor was HCT, which adversely influenced survival in IM patients

Modeling and Exploitation Load Tests of the Suspended Route Slings Caused by Passage of the Locomotive at Various Speed along Mining Excavation

Despite the fact that suspended monorails have been used in the mining industry for over 50 years it is necessary to continue research on the possibilities of increasing the unit mass of the transported load or the speed of people transport. The first step is to establish the exact dynamic load of suspended route’ elements and compare this value with easy to calculation static load. The objective of the research was to determine the influence of speed and direction of travel on maximum load force applied to the sling of the route in mining excavation. The research results indicated that the speed of 2 ms−1 does not significantly influence the load on the sling. Theoretical hypothesis, stating that the estimation of the force value in the sling ought to be performed using projecting on a surface perpendicular to the route was confirmed. It was also proven that in order to characterize the geometry of the sling as well as a precise analysis of its load it is necessary to employ the length and the angle of the chain in relation to the above mentioned surface. Upon employing statistical analysis of the test results, the maximum dynamic effect of the locomotive passing was determined to be 20.1 ± 2.5% of the value of the calculated static load for all slings, projected onto a plane perpendicular to the route. For a single sling, mounted on a test route section inclined at an angle of about 10°, the increase in force due to the passage of the locomotive was up to 21.0% of the static load for this sling

Production of oxide coatings by sol-gel method and electrophoresis

The paper reports the results of depositing SiO2 and SiO2-TiO2 coatings on titanium alloy Ti-6Al-4V ELI (ASTM-grade 5). Oxide coatings were deposited onto the titanium alloy substrate by sol-gel method and by electrophoresis. The produced coatings were chemically uniform, compact and highly dense. We then performed SEM microstructure examination, as well as microhardness and surface roughness measurements for different coating combinations. The significance of the results was assessed by the Shapiro-Wilk and t-Student tests using the STATISTICA software. It has been found that there are statistically significant differences in the hardness of SiO2 and SiO2-TiO2 coatings. The results of roughness parameters reveal significant differences only for individual coatings

Fractographic Assessment and FEM Energy Analysis of the Penetrability of a 6061-T Aluminum Ballistic Panel by a Fragment Simulating Projectile

In aviation and light vehicles, aluminum plates are often used instead of heavy shields as ballistic shields. The standard shrapnel was used in the analysis due to the fact that under hazardous conditions, the shrapnel destruction occurs more often than directly with a bullet. Analyses were performed in which the initial velocity and the angle of impact were the variables. The material of the aluminum plate (ballistic shield) with a thickness of 1 mm was divided into three-dimensional C3D4 tetragonal elements. The calculations were performed using the Johnson-Cook model for the impact at an adjustable velocity from 25 m/s to 55 m/s every 10 m/s and impact angle set between 0° and 45° in increments of 15°. Stress maps that allow observation of the plate degradation areas were placed in the plate. It was found that the penetration of the ballistic panel by the fragment under simulated conditions occurs at the initial velocity of this fragment greater than 25 m/s. The fragment simulating a projectile, hitting at a velocity of 35 m/s at an angle of not more than 15° perforates this panel. At an impact velocity of 45 m/s, perforation occurred at an impact angle of up to 30°. A further increase of the fragment’ velocity of impact on the plate resulted in its perforation even at the greatest impact angle

Mechanical system detector of weight in motion system

The multi-sensor and mechanical WIM systems were characterised. The assumption of the necessity of simultaneous analysis of vehicles types (by number of wheels, e.g. two-wheelers, four wheelers, etc.) participating in traffic, was made. This type of analysis involves not only the measurement of vehicle weight but also qualitative detection. Such data are mainly collected and analysed in urban traffic, in which information on traffic volume, lane occupancy or the number of vehicles waiting to enter an intersection are important to ensure continuous, smooth traffic flow. This article presents a design of a WIM system in which the detector is a beam with Bragg grating optical fibre sensors glued on it. Four cases of beam load were determined, due to its strength and the ability to register deformations. The strength analysis of the beam was carried out with the help of MES and its shape was optimised

Mechanical system detector of weight in motion system

The multi-sensor and mechanical WIM systems were characterised. The assumption of the necessity of simultaneous analysis of vehicles types (by number of wheels, e.g. two-wheelers, four wheelers, etc.) participating in traffic, was made. This type of analysis involves not only the measurement of vehicle weight but also qualitative detection. Such data are mainly collected and analysed in urban traffic, in which information on traffic volume, lane occupancy or the number of vehicles waiting to enter an intersection are important to ensure continuous, smooth traffic flow. This article presents a design of a WIM system in which the detector is a beam with Bragg grating optical fibre sensors glued on it. Four cases of beam load were determined, due to its strength and the ability to register deformations. The strength analysis of the beam was carried out with the help of MES and its shape was optimised

GEOMETRIC OPTIMIZATION OF A BEAM DETECTOR FOR A WIM SYSTEM

Weigh-in-Motion (WIM) systems are designed for weighing vehicles driving across a measurement site. Because during measurements the vehicle has to come in physical contact with the components of the system, WIM systems always use built-in sensors installed in road pavement. Each WIM system consists of force sensors placed in one, two or even several lines, perpendicular to the direction of traffic. The idea behind WIM systems is to measure the dynamic loads that the wheels of a moving vehicle exert on the road surface and, on this basis, to estimate static wheel loads as well as gross vehicle weight