Side effects of antiviral drugs used in respiratory infections a review

Since the 12th century, mankind has experienced more than 130 viral epidemics and influenza pandemics. The 21st century is no exception. The relatively "new" strains of influenza have been replaced by new infections, in particular, the coronavirus infection -COVID-19 (the official name SARS-CoV-2), the third peak of the pandemic of which we are now seeing. At the same time, the "old" viral infections have not disappeared anywhere. Using antiviral drugs in the treatment of respiratory infections, not only the medical and economic efficiency of the application must be taken into account, but also remember several side effects of the drugs, preventing them whenever possible and minimizing their consequences. The purpose of the publication is to systematize, analyze and summarize literature data on typical adverse reactions of antiviral drugs active against pathogens of acute viral respiratory infections. Keywords: antiviral drugs, side effects, respiratory infections

The versatility of carboxytherapy in pathogenic therapy

Carbon dioxide is a powerful physiological regulator (physiological and pharmacological pacemaker) of numerous body systems: cardiovascular, respiratory, nervous, excretory, hematopoietic, immune,etc. Therefore, at present, carboxytherapy, due to the universal nature of pharmacodynamics, its physiology is one of the methods widely used in medicine for the treatment of a large number of diseases and has received official recognition in many countries worldwide. The use of CO2 in surgery is not limited to disinfection of surgical wounds, wound healing, anti-inflammatory, hemostatic and antioxidant effects. Inhaling carbon dioxide in a low concentration (3-5%) has a reflex stimulating effect on the respiratory and vasomotor centers of the medulla oblongata: it causes deep and rapid breathing, and excitation of the vasomotor center - an increase in heart rate and blood pressure. This reflex effect of CO2 is used during anesthesia to stimulate pulmonary ventilation with a mixture of CO2 and O2 (carbogen) while suppressing pulmonary ventilation. Inhalation of CO2 helps with vascular collapse to increase cerebral blood flow. Thus, carboxytherapy in the complex of pharmacotherapeutic treatment of diseases is a worthy alternative to drugs that have synergistic pathogenetic (antioxidant, antihypoxic, anti-inflammatory) and symptomatic (vasodilator, analgesic, hypolipidemic, antiseptic, reparative) effects. Keywords: carbon dioxide, carboxytherapy, pathogenic therapy