Impeller optimization in crossflow hydraulic turbines

Crossflow turbines represent a valuable choice for energy recovery in aqueducts, due to their constructive simplicity and good efficiency under variable head jump conditions. Several experimental and numerical studies concerning the optimal design of crossflow hydraulic turbines have already been proposed, but all of them assume that structural safety is fully compatible with the sought after geometry. We show first, with reference to a specific study case, that the geometry of the most efficient impeller would lead shortly, using blades with a traditional circular profile made with standard material, to their mechanical failure. A methodology for fully coupled fluid dynamic and mechanical optimization of the blade cross-section is then proposed. The methodology assumes a linear variation of the curvature of the blade external surface, along with an iterative use of two-dimensional (2D) computational fluid dynamic (CFD) and 3D structural finite element method (FEM) simulations. The proposed methodology was applied to the design of a power recovery system (PRS) turbine already installed in an operating water transport network and was finally validated with a fully 3D CFD simulation coupled with a 3D FEM structural analysis of the entire impeller

Performance improvement of a drag hydrokinetic turbine

Hydropower is at present in many locations, among all the other possible renewable energy sources, the best one for net cost per unit power. In contrast to traditional installation, based on water storage in artificial basins, free flow river turbines also provide a very low environmental impact due to their negligible effect on solid transport. Among them, kinetic turbines with vertical axis are very inexpensive and have almost zero impact on fish and local fauna. In application to tidal waves and sea waves, where vertically averaged velocities have alternate direction, a Savonius rotor also has the advantage of being productive during the whole time cycle. In this work, the effect of an upstream deflector system mounted upstream of a twisted Savonius rotor inside a channel has been investigated through numerical simulations and experimental tests. Numerical simulations were carried on using the ANSYS FLUENT 17.0 software. Based on this numerical study, it is shown that the proposed deflector system has improved the power coefficient of the Savonius rotor by 14%. The utilization of this new design system is predicted to contribute towards a more efficient use of flows in rivers and channels for electricity production in rural areas

Collateral circulation: Past and present

Following an arterial occlusion outward remodeling of pre-existent inter-connecting arterioles occurs by proliferation of vascular smooth muscle and endothelial cells. This is initiated by deformation of the endothelial cells through increased pulsatile fluid shear stress (FSS) caused by the steep pressure gradient between the high pre-occlusive and the very low post-occlusive pressure regions that are interconnected by collateral vessels. Shear stress leads to the activation and expression of all NOS isoforms and NO production, followed by endothelial VEGF secretion, which induces MCP-1 synthesis in endothelium and in the smooth muscle of the media. This leads to attraction and activation of monocytes and T-cells into the adventitial space (peripheral collateral vessels) or attachment of these cells to the endothelium (coronary collaterals). Mononuclear cells produce proteases and growth factors to digest the extra-cellular scaffold and allow motility and provide space for the new cells. They also produce NO from iNOS, which is essential for arteriogenesis. The bulk of new tissue production is carried by the smooth muscles of the media, which transform their phenotype from a contractile into a synthetic and proliferative one. Important roles are played by actin binding proteins like ABRA, cofilin, and thymosin beta 4 which determine actin polymerization and maturation. Integrins and connexins are markedly up-regulated. A key role in this concerted action which leads to a 2-to-20 fold increase in vascular diameter, depending on species size (mouse versus human) are the transcription factors AP-1, egr-1, carp, ets, by the Rho pathway and by the Mitogen Activated Kinases ERK-1 and -2. In spite of the enormous increase in tissue mass (up to 50-fold) the degree of functional restoration of blood flow capacity is incomplete and ends at 30% of maximal conductance (coronary) and 40% in the vascular periphery. The process of arteriogenesis can be drastically stimulated by increases in FSS (arterio-venous fistulas) and can be completely blocked by inhibition of NO production, by pharmacological blockade of VEGF-A and by the inhibition of the Rho-pathway. Pharmacological stimulation of arteriogenesis, important for the treatment of arterial occlusive diseases, seems feasible with NO donors

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

Symplectic invariants and covariants of matrices

International audienceThis paper deals with symplectic algebraic invariants and covariantsof matrices. We adapt the Aronhold symbolic method to characterizeand compute the generators of algebras of symplectic invariants andcovariants. New symplectic identities are obtained and applied toconstruct minimal generator systems of a matrix of order 4 and aHamiltonian matrix of order 2n

Effect of the Converging Pipe on the Performance of a Lucid Spherical Rotor

Lucid spherical rotor is a cross-\ufb02ow rotor developed to be installed within a pipeline. The purpose of installing this type of rotor is to collect excess energy available in gravity-fed water pipelines. In order to enhance the ef\ufb01ciency of the rotor which is installed in a channel, this paper aims to study the performance of Lucid spherical rotor with converging pipe. Numerical investigations were carried out to analyze the effect of the converging pipe on the performance of the rotor. Numerical simulations have been carried out using the unsteady Reynolds-averaged Navier\u2013Stokes equations in conjunction with the realizable k 12\u3b5 turbulence model. The validation of the numerical method with anterior published studies has been carried out. The hydrodynamic characteristics of the \ufb02ow around therotor with and without converging pipe have been analyzed and discussed. Numerical results indicated that the converging pipe increases the performance of the Lucid spherical rotor