67/1/9 Letter from Chief Drenkhan to F. Lee Bailey

Chief Drenkhan informs F. Lee Bailey of Cuyahoga County Grand Jury decision not to indict anyone for Marilyn Sheppard\u27s murder based on the information Bailey provided in his 11/28/66 letter to Drenkhan

Supplementary Offense Report, July 28, 1954, Bay Village Police Department

Report of Patrolman Fred Drenkhan\u27s visit with hospital Chief Administrator Richard Lease regarding information about employees of Bay View Hospital. Information includes names and addresses of employees who were let go prior to the murder as well as names of department heads

Supplementary Offense Report, July 28, 1954, Bay Village Police Department

Report of Patrolman Fred Drenkhan\u27s visit with hospital Chief Administrator Richard Lease regarding information about employees of Bay View Hospital. Information includes names and addresses of employees who were let go prior to the murder as well as names of department heads

66/11/28 Letter from Chief Drenkhan to F. Lee Bailey

Letter from Chief Bailey to F. Lee Bailey, acknowledging receipt of Bailey\u27s letter, hand delivered by Sam Sheppard

Statement given to BVPD by Spencer Houk

Statement provided to BVPD by Spencer Houk regarding the Marilyn Sheppard murder. Spencer Houk details the morning of July 4th from the phone call Sam Sheppard placed to the Houk residence to what he encountered after entering the Sheppard home. Spencer and Esther Houk were the first individuals to respond to Sam Sheppard\u27s call for help. Their statements are provided in this collection as context for those who considered the Houks to be suspects

The relationship between insulin binding, insulin activation of insulin-receptor tyrosine kinase, and insulin stimulation of glucose uptake in isolated rat adipocytes

We have studied the relationship between insulin activation of insulin-receptor kinase and insulin stimulation of glucose uptake in isolated rat adipocytes. Glucose uptake was half-maximally or maximally stimulated, respectively, when only 4% or 14% of the maximal kinase activity had been reached. To investigate this relationship also under conditions where the insulin effect on activation of receptor kinase was decreased, the adipocytes were exposed to 10 microM-isoprenaline alone or with 5 micrograms of adenosine deaminase/ml. An approx. 30% (isoprenaline) or approx. 50% (isoprenaline + adenosine deaminase) decrease in the insulin effect on receptor kinase activity was found at insulin concentrations between 0.4 and 20 ng/ml, and this could not be explained by decreased insulin binding. The decreased insulin-effect on kinase activity was closely correlated with a loss of insulin-sensitivity of glucose uptake. Moreover, our data indicate that the relation between receptor kinase activity and glucose uptake (expressed as percentage of maximal uptake) remained unchanged. The following conclusions were drawn. (1) If activation of receptor kinase stimulates glucose uptake, only 14% of the maximal kinase activity is sufficient for maximal stimulation. (2) Isoprenaline decreases the coupling efficiency between insulin binding and receptor-kinase activation, this being accompanied by a corresponding decrease in sensitivity of glucose uptake. (3) Our data indicate that the signalling for glucose uptake is closely related to receptor-kinase activity, even when the coupling efficiency between insulin binding and kinase activation is altered. They thus support the hypothesis that receptor-kinase activity reflects the signal which originates from the receptor and which is transduced to the glucose-transport system

67/1/9 Letter from Chief Drenkhan to F. Lee Bailey

Chief Drenkhan informs F. Lee Bailey of Cuyahoga County Grand Jury decision not to indict anyone for Marilyn Sheppard\u27s murder based on the information Bailey provided in his 11/28/66 letter to Drenkhan

Supplementary Offense Report, July 28, 1954, Bay Village Police Department

Report of Patrolman Fred Drenkhan\u27s visit with hospital Chief Administrator Richard Lease regarding information about employees of Bay View Hospital. Information includes names and addresses of employees who were let go prior to the murder as well as names of department heads

Statement given to BVPD by Esther Houk

Statement provided to BVPD by Esther Houk regarding the Marilyn Sheppard murder. Esther Houk details the morning of July 4th from the phone call Sam Sheppard placed to the Houk residence to what she encountered after entering the Sheppard home. Spencer and Esther Houk were the first individuals to respond to Sam Sheppard\u27s call for help. Their statements are provided in this collection as context for those who considered the Houks to be suspects