Enhanced Data Return from Lunar Farside using RF-Optical TT and C

Science return and high bandwidth communications are key issues to support the foreseen endeavours on spaceflights to the Moon and beyond. For a given mass, power consumption and volume, laser communications can offer an increase in TM bandwidth over classical RF technology allowing for a variety of new options, specifically to missions that require very large distances, such as to the Moon and even beyond. This increase in TM data rate allows for more raw scientific data to be sent back to Earth where data processing can be performed on ground. Enhanced sensing techniques could be used that generate more science data and access during flight could be faster. This paper presents an overview of proof of concept test results obtained for optical telemetry return in a field test campaign together with ESA in October 2007. Based on the results obtained, a sample mission is outlined that shows an optical relay on a HALO trajectory at lunar farside, using an integrated RF-optical TT&C transponder concept

Eryptosis: Programmed Death of Nucleus-Free, Iron-Filled Blood Cells

Human erythrocytes are organelle-free cells packaged with iron-containing hemoglobin, specializing in the transport of oxygen. With a total number of approximately 25 trillion cells per individual, the erythrocyte is the most abundant cell type not only in blood but in the whole organism. Despite their low complexity and their inability to transcriptionally upregulate antioxidant defense mechanisms, they display a relatively long life time, of 120 days. This ensures the maintenance of tissue homeostasis where the clearance of old or damaged erythrocytes is kept in balance with erythropoiesis. Whereas the regulatory mechanisms of erythropoiesis have been elucidated over decades of intensive research, the understanding of the mechanisms of erythrocyte clearance still requires some refinement. Here, we present the main pathways leading to eryptosis, the programmed death of erythrocytes, with special emphasis on Ca(2+) influx, the generation of ceramide, oxidative stress, kinase activation, and iron metabolism. We also compare stress-induced erythrocyte death with erythrocyte ageing and clearance, and discuss the similarities between eryptosis and ferroptosis, the iron-dependent regulated death of nucleated blood cells. Finally, we focus on the pathologic consequences of deranged eryptosis, and discuss eryptosis in the context of different infectious diseases, e.g., viral or parasitic infections, and hematologic disorders

Optical GEO Feeder Link Design

Abstract: Telecommunication satellites must follow the advances of terrestrial network capacities and increase their total throughputs in order to remain competitive. This paper shows how the terrestrial fibre technology at 1550-nm wavelength can be extended to support an optical feeder link between ground and a GEO satellite. With 100 Gb/s in a single direction, an optical uplink would outperform the near-term Ka-band systems. Mitigation techniques against clouds and turbulence are described. The impact of satellite transparency on the optical transmission system is discussed. To increase the profitability of the optical solution, cost and link availability associated with various ground station networks should be carefully assessed

Implications of Sky Radiance On Deep-Space Optical Communication Links

As the number of deep-space missions that are turning to optical communications to support science operations increases, system designers are taking a more in depth look at the link budgets that govern such links. Noise sources, such as the radiance arising from scattering in the Earth’s atmosphere and light reflected from planetary bodies in close visual proximity to spacecraft, become particularly critical given the photon-starved channels normally associated with deep-space links. In the case of the Earth’s atmosphere, sky radiance becomes a significant factor when considering daytime operations especially when operators need to support spacecraft contacts close to the Sun. This paper encapsulates the implications of sky radiance on deep-space optical communication scenarios and provides an overview of the current efforts underway in Europe to further quantify its impact on future mission operations

The specific PKC-α inhibitor chelerythrine blunts costunolide-induced eryptosis

Costunolide, a natural sesquiterpene lactone, has multiple pharmacological activities such as neuroprotection or induction of apoptosis and eryptosis. However, the effects of costunolide on pro-survival factors and enzymes in human erythrocytes, e.g. glutathione and glucose-6-phosphate dehydrogenase (G6PDH) respectively, have not been studied yet. Our aim was to determine the mechanisms underlying costunolide-induced eryptosis and to reverse this process. Phosphatidylserine exposure was estimated from annexin-V-binding, cell volume from forward scatter in flow cytometry, and intracellular glutathione [GSH

Pharmacological targeting of glucose-6-phosphate dehydrogenase in human erythrocytes by Bay 11-7082, parthenolide and dimethyl fumarate

In mature erythrocytes, glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) yield NADPH, a crucial cofactor of the enzyme glutathione reductase (GR) converting glutathione disulfide (GSSG) into its reduced state (GSH). GSH is essential for detoxification processes in and survival of erythrocytes. We explored whether the anti-inflammatory compounds Bay 11-7082, parthenolide and dimethyl fumarate (DMF) were able to completely deplete a common target (GSH), and to impair the function of upstream enzymes of GSH recycling and replenishment. Treatment of erythrocytes with Bay 11-7082, parthenolide or DMF led to concentration-dependent eryptosis resulting from complete depletion of GSH. GSH depletion was due to strong inhibition of G6PDH activity. Bay 11-7082 and DMF, but not parthenolide, were able to inhibit the GR activity. This approach "Inhibitors, Detection of their common target that is completely depleted or inactivated when pharmacologically relevant concentrations of each single inhibitor are applied, Subsequent functional analysis of upstream enzymes for this target" (IDS), can be applied to a broad range of inhibitors and cell types according to the selected target. The specific G6PDH inhibitory effect of these compounds may be exploited for the treatment of human diseases with high NADPH and GSH consumption rates, including malaria, trypanosomiasis, cancer or obesity