A persisting secular trend for body measurements in Dutch children. The Oosterwolde II Study

A persisting secular trend for body measurements in Dutch children. The Oosterwolde II Study. Gerver WJ, De Bruin R, Drayer NM. Department of Pediatrics, University of Limburg, The Netherlands. To investigate whether the secular trend for growth in Dutch children still exists, the Oosterwolde I study of 1980 was repeated in 1989. A persisting secular trend was visible for height while the z scores of body proportions show no change during the past 10 years, which suggests that there is no change in the timing of pubert

Kinetics of cortisol metabolism and excretion: A hypothetic model based on the cumulative urinary radioactivity in eight multiple pituitary deficient patients

A new model is proposed to study the kinetics of [H-3]cortisol metabolism by using urinary data only. The model consists of 5 pools, in which changes of the fractions of dose are given by a system of 5 ordinary differential equations. After i.v. administration of [H-3]cortisol to 8 multiple pituitary deficient (MPD) patients (group I) the urines from each patient were collected in 9-15 portions during the following 3 days. From the urinary data the rate constants of cortisol metabolism were calculated. A published set of urinary data from patients with a normal cortisol metabolism (group II) was used for comparison. The overall half-life of the label in the circulation was 30 min for both groups; the half-life of the label excretion by both groups was 6 h and the time of maximal activity in the main metabolizing pool was 1.8 h in group I and 1.5 h in group II. The 20% of normal cortisol production rate (CPR) in the 8 MPD patients amounted to 7.2 +/- 1.9-mu-mol/(m2*d). Therefore, the low CPR but normal rate constants, i.e. a normal metabolic clearance rate of cortisol, in the MPD patients suggest a sensitive adjustment of the cortisol response in the target organs

Synthesis And Physicochemical Properties Of [19,20-13 C]-17alfa-ethinylestradiol

13C2-17a-ethinylestradiol (13C2-EE2) was synthesized from estrone and 13C2- C2H2-gas to measure the metabolic clearance rate and the plasma concentration of 17a-ethinylestradiol (EE2) in tall girls, who are treated with high dosages of this estrogen. Interesting characteristics determined by (i) MS: the molecular ion m/z 298.183 is the only labelled ion in the spectrum, and by (ii)1H-NMR d(ppm) 2.96 (dd, 1J(13C-H)=249 Hz, 2J(13C-H)=49.6 Hz; 1H; H20) and (iii) 13C-NMR d 88.8(dd, 1J(13C-13C)=166 Hz, 2J(13C-H20)=49.8 Hz; C19); 80.2 (dd, 1J(13C17-13C19)= 73 Hz, 2J(13C17-13C20)=12.3 Hz; C17) and 74.6 (dd, 1J(13C-13C)=166 Hz, 1J(13C-H)= 249 Hz; C20) confirm the synthesis and structure of 13C2-EE2.

Synthesis and Physicochemical Properties of [19,20-13C]-17α-Ethinylestradiol

13C2-17α-ethinylestradiol (13C2-EE2) was synthesized from estrone and 13C2-C2H2-gas to measure the metabolic clearance rate and the plasma concentration of 17α-ethinylestradiol (EE2) in tall girls, who are treated with high dosages of this estrogen. Interesting characteristics determined by (i) MS: the molecular ion m/z 298.183 is the only labelled ion in the spectrum, and by (ii)1H-NMR δ(ppm) 2.96 (dd, 1J(13C-H)=249 Hz, 2J(13C-H)=49.6 Hz; 1H; H20) and (iii) 13C-NMR δ 88.8(dd, 1J(13C-13C)=166 Hz, 2J(13C-H20)=49.8 Hz; C19); 80.2 (dd, 1J(13C17-13C19)= 73 Hz, 2J(13C17-13C20)=12.3 Hz; C17) and 74.6 (dd, 1J(13C-13C)=166 Hz, 1J(13C-H)= 249 Hz; C20) confirm the synthesis and structure of 13C2-EE2.

Effect of growth hormone treatment on craniofacial growth in Turner's syndrome

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