10 research outputs found
Porphyrins with directly meso-attached disaccharide moieties: Synthesis, self-assembly and cellular study
No full textAnaerobes and their fermentation products in faeces of patients with familial adenomatous polyposis before and after subtotal colectomy and ileorectal anastomosis
No full textBifidobacteria and probiotic effects: Action of Bifidobacterium species on conjugated bile salts
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Regulation of Candida albicans Populations in the Gastrointestinal Tract: Mechanisms and Significance in GI and Systemic Candidiasis
No full textComparison of the gut microbiota composition between wild and captive sika deer (Cervus nippon hortulorum) from feces by high-throughput sequencing
No full textCardiac iron overload in chronically transfused patients with thalassemia, sickle cell anemia, or myelodysplastic syndrome
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The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism
No full textAlthough the significance of human genetic polymorphisms in therapeutic outcomes is well established, the importance of our “second genome” (the microbiome) has been largely overlooked. In this Review, we highlight recent studies that shed light on the mechanisms linking the human gut microbiome to the efficacy and toxicity of xenobiotics, including drugs, dietary compounds and environmental toxins. Continued progress in this area could enable more precise tools for predicting patient responses and the development of a next generation of therapeutics based on or targeted at the gut microbiome. Indeed, the admirable goal of precision medicine may require us to first understand the microbial pharmacists within
