Consensus recommendations of the german consortium for hereditary breast and ovarian cancer

BACKGROUND: The German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) has established a multigene panel (TruRisk®) for the analysis of risk genes for familial breast and ovarian cancer. SUMMARY: An interdisciplinary team of experts from the GC-HBOC has evaluated the available data on risk modification in the presence of pathogenic mutations in these genes based on a structured literature search and through a formal consensus process. KEY MESSAGES: The goal of this work is to better assess individual disease risk and, on this basis, to derive clinical recommendations for patient counseling and care at the centers of the GC-HBOC from the initial consultation prior to genetic testing to the use of individual risk-adapted preventive/therapeutic measures

Improved Distributed Prescribed Finite-Time Secondary Control of Inverter-Based Microgrids: Design and Real-Time Implementation

The aim of this study is to develop a novel distributed robust prescribed finite-time secondary control for both frequency and voltage restoration along with accurate active power sharing in islanded microgrids (MGs). The prescribed finite-time convergence property irrespective of the values of initial conditions helps to design an offline settling time that leads to power loss reduction. Moreover, thanks to the use of a piecewise-function based approach the upper bound of convergence time is reduced. The fixed-time stability of the proposed scheme is rigorously confirmed by applying the Lyapunov theory, which results in a set of tuning rules. The main challenge is to establish the stability conditions through asymmetrical connections under a directed graph. Finally, the architecture of the experimental setup is constructed for an inverter-based microgrid consisting of six distributed generators (DGs). The OPAL-RT real-time simulator is exploited to verify the applicability of the proposed distributed fixed-time controller

Consensus Recommendations of the German Consortium for Hereditary Breast and Ovarian Cancer

Background: The German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) has established a multigene panel (TruRisk (R)) for the analysis of risk genes for familial breast and ovarian cancer. Summary: An interdisciplinary team of experts from the GC-HBOC has evaluated the available data on risk modification in the presence of pathogenic mutations in these genes based on a structured literature search and through a formal consensus process. Key Messages: The goal of this work is to better assess individual disease risk and, on this basis, to derive clinical recommendations for patient counseling and care at the centers of the GC-HBOC from the initial consultation prior to genetic testing to the use of individual risk-adapted preventive/therapeutic measures