The Biology Of Platelet-Rich Plasma In Regenerative Medicine

Background: Platelet-rich plasma (PRP) is a blood derivative prepared via centrifugation, characterized by an elevated platelet concentration, typically 4 to 6 times higher than average. Objective: To provide a comprehensive review of PRP, assessing its biological foundation, established applications, and emerging potential in regenerative medicine. Methods: A critical analysis of literature from its inception in 1980, when PRP was first utilized for healing skin ulcers, encompassing diverse medical fields such as ophthalmology, otorhinolaryngology, maxillofacial, aesthetic surgery, surgical wounds, skeletal muscle disorders, burns, and peripheral nerve repair. Results: PRP is rich in trophic factors, suggesting its potential in tissue repair and regeneration. However, despite extensive research and clinical evaluations, its efficacy remains inconclusive in several therapeutic areas. The current evidence underscores the necessity for methodologically rigorous clinical trials to bolster the evidence base supporting PRP's therapeutic potential. Conclusion: While PRP shows promise in various applications within regenerative medicine, continued research and robust clinical trials are imperative to ascertain its efficacy definitively and optimize its therapeutic utilization