ANALYSIS OF BLOOD CIRCULATING SERUM BIOMARKERS FOR THE DIAGNOSIS OF BREAST CANCER

Introduction: Breast cancer is the most common neoplasm in women and the second leading cause of cancer-related mortality in females worldwide. Breast cancer is the second most common type of cancer (after lung cancer), and the fifth most common cause of cancer death. Objectives of the study: The main objective of the study is to assess the blood circulating serum biomarkers for the diagnosis of breast cancer. Methodology of the study: This cross sectional study was conducted at DHQ teaching hospital Sahiwal during February 2018 to November 2018. Breast cancer notifications were confirmed and characterized by postal questionnaire sent to treating clinicians (consultant, or General Practitioner if details not provided by the volunteer), which was designed to ascertain clinical and histological data on diagnosed cases (date of diagnosis, histology, nodal status, staging, grade, prognosis, ER, PR and HER2 status). Results: The results indicates that CTC, CEA and ALP are the best indicating serum biomarkers for the diagnosis and progression of breast cancer. Mean, median and SD shows that there is a significant relationship in these serum biomarkers. Conclusion: It is concluded that biomarkers are the useful tool for the analysis of progression of breast cancer in females. Key words: Diagnosis, Breast, Cancer, Female