The role of Coenzyme Q10 in statin-associated myopathy

Statins, or 3-hydroxyl-3-methylglutaryl coenzyme HMG-CoA reductase inhibitors,\ud are cholesterol-lowering drugs which are frequently used in the primary and secondary\ud prevention of coronary artery disease. Current research and recommendations support\ud and encourage more extensive use of these drugs.\ud However, statin usage is limited by many factors, including a high incidence of\ud statin-associated myalgia and myopathy. This review focuses on the use of Coenzyme Q\ud in statin-associated myopathy

To Conduct the Health Appraisal Survey amongst Hospital Personnel Working in Secondary Level Health Care Institution of Haryana and Study the Effect of Job Profile / Duration on their Health

Health is a state subject but being in good health and maintaining it is also an individual responsibility. Being in health department does not ensure good health for life time. All employees undergo medical examination before joining services, but none of them under go yearly health screening in service. Over a period of time due to wear and tear, stress and strain, the body systems give way and the Health Army is no more healthy. Moreover, there is lack of accountability on the part of the employer to safe guard the health of employees from occupational hazards which they are exposed to, each day of services.Good health of hospital workers is requisite to the health of these patients, however, and is therefore of profound importance. Hence there is need for periodic health appraisal to ensure healthy work force. When employees are aware that the hospital is mindful of their performance and health, they take care of job a responsibility which in turn is related to improved efficiency in hospital services

My Work is for a King

GUEST EDITORIA

Transgender Health Issues: Children of a Lesser God

The transgender community is a distinct population, with its unique health care needs, wishes and preferences. This calls for an enhanced focus on transgender health issues, as an integral part of the health care system, and also through specialized multidisciplinary centers of excellence. The authors call for sensitization of the health care profession, and request for sensitivity while managing transgender and gender diverse individuals. If this is accomplished, transgender health issues will become normalized as part of the wider spectrum of health care, just as being a transgender person is normal

Optimizing Finerenone Therapy: A Comprehensive Review Using the “Finerenone Pentad”

Chronic kidney disease (CKD) is a pressing global health concern, often intertwined with comorbid conditions such as type 2diabetes mellitus (T2DM) and cardiovascular complications. Managing CKD in T2DM patients requires a multifaceted approach,and emerging therapeutic options are increasingly essential. Finerenone, a selective nonsteroidal mineralocorticoid receptorantagonist, has shown considerable promise in addressing the intricate cardiorenal needs of these patients. To maximize theeffectiveness of this therapy, we propose the approach of “Finerenone Pentad” which can be utilized as a checklist while startingand subsequently monitoring the finerenone therapy. This structured approach offers guidance on patient selection, monitoringand outcome evaluation, ensuring a holistic approach to the care of individuals with T2DM and CKD.&nbsp

Semaglutide: Untangling the Gordian Knot of Glucose Control

GUEST EDITORIA

Rational Renometrics

The precise evaluation of renal function and structure is indispensable clinical medicine. This is required not only to screen,diagnose and monitor kidney disease, but also to allow accurate choice of drugs and their dosages while treating individuals.Traditional methods, exemplified by glomerular filtration rate (GFR) calculations and urinalysis, have long served as pillarsof nephrology. However, their inherent limitations introduce diagnostic ambiguities, raising concerns for both health careproviders and patients. This comprehensive review introduces the concept of "Rational Renometrics", a transformativeapproach that harmonizes various tests and factors to provide a holistic assessment of renal health. It focuses on correcturine sample collection, mitigates false positives in urinalysis and embraces the concept of permissive hypercreatinemia.The evidence-based, data-driven perspective of rational renometrics empowers health care providers and patients, leadingto more accurate diagnoses, individualized treatment strategies and improved therapeutic outcomes. Rational renometricsallows accurate risk assessment and institution of preventive interventions, reinforcing its pivotal role in preserving renalhealth and optimizing patient care. We describe the principles, advantages, challenges and potential clinical applications ofrational renometrics, emphasizing the need for continued research and validation of this concept

Overweight and Obesity: Opening an Opportunity for Health

Obesity is now recognized as a disease and is often preceded by an overweight status in its natural history of development. Though excess fat is often associated with morbidity, stigma and mortality, this editorial provides a unique perspective of identifying obesity and overweight status as a window of opportunity. The authors reflect how people living with obesity can be identified, motivated and managed, to ensure optimal comprehensive health. Overweight and obesity, two frequently used words, are defined as abnormal or excessive fat accumulation that may impair health.1 These medical conditions can be easily identified in clinical practice by measuring body mass index (BMI). This is calculated by dividing an individual’s weight (kilogram) by the square of his/her height (meters squared).2 Indian standards define overweight as a BMI >23 kg/m2, and obesity as a BMI >25 kg/m2. Outside Asia, however, the thresholds used to define overweight and obesity are 25 and 30 kg/m2, respectively. In children aged 5 to 19 years, age-specific BMI cut offs are used, while in younger children, weight-for-height ratios are calculated to assess weight health

Imeglimin: Finding a Place in Modern Diabetes Pharmacotherapeutics

Type 2 diabetes mellitus (T2DM) is a multifactorial disease. Newer facets of its causation, clinical course, complications and therapy are being unraveled regularly. This editorial describes imeglimin, a first-of-class oxidative phosphorylation inhibitor, that has been approved for T2DM in Japan and India

Obesity and the Banyan Tree

Health is a multifaceted construct, with social, religious and spiritual dimensions. In this editorial, we use an important socioreligious icon, the banyan tree (Ficus benghalensis) as a metaphor for the etiopathogenesis, clinical evaluation and managementof obesity. We utilize this as a motivational tool, to encourage self-discipline and self-care while living with obesity