Устойчивость к антибиотикам при респираторных инфекциях: новые альтернативы для преодоления

Universitatea de Stat de Medicină şi Farmacie Nicolae Testemiţanu, Conferinţa consacrată aniversării celor 40 de ani de la fondarea SCM Sfânta Treime 17 iunie 2016 Chișinău, Republica MoldovaAntibiotic resistance represents a serious global public health problem, with a rapid progression, a permanent increase of mortality and morbidity indices and a poor prognosis, which led to the new researches for the discovery of new therapies, the use of antibiotics and stopping bacterial resistance progression in respiratory infections. In addition to new antimicrobians, use of bacteriophages, pneumococcal and influenza vaccination, recent data provides us with new information about alternative ways of overcoming the microbial resistance, such as toxins- antitoxins, teixobactin, bacteriocins, various components of plants used as antibacterial agents.Устойчивость к антибиотикам – серьезная глобальная проблема общественного здравоохранения с быстрым прогрессированием, постоянным увеличением показателей смертности и заболеваемости и плохим прогнозом, что побудило дальнейшие исследования, чтобы остановить прогрессирование бактериальной резистентности при респираторных инфекциях. В дополнение к новым антибактериальным препаратам, терапии бактериофагами, вакцинации против гриппа и пневмококка, в последние годы в литературе появляется информация об альтернативных способах преодоления бактериальной резистентности, таких как токсины – антитоксины, тейксобактин, бактериоцины, различные растительне компоненты, использованных в качестве антибактериальных препаратов

Анализ летальности в отделении внутренних болезней № 1 за период 2006-2015 годов

IP USMF Nicolae Testemiţanu, IMSP SCM Sfânta Treime, Conferinţa consacrată aniversării celor 40 de ani de la fondarea SCM Sfânta Treime 17 iunie 2016 Chișinău, Republica MoldovaThe article represents the analysis of letality of the Department of internal diseases no. 1 of PMSI Municipal Clinical Hospital „Sfanta Treime” during the decade of 2006-2015. Thus, elevations of letality every five years coinciding with the epidemics of flu were observed. The percentage of patients over 60 years remains constantly predominant. The first three places in the letality structure are occupied by respiratory, cardiovascular and neoplastic diseases.В данной статье представлен анализ летальности в отделении внутренних болезней № 1 ПМСУ ГКБ „Сфынта Треиме” за период 2006-2015 годов. Таким образом, отмечено появление пиков летальности каждые 5 лет, совпадающие с эпидемиями гриппа. Доля больных в возрасте свыше 60 лет постоянно превалирует среди других возрастных групп. Первые три места в структуре летальности отводятся респираторным, сердечнососудистым и онкологическим заболеваниям

Сравнительное исследование заболеваемости в отделение терапии № 1 на протяжении десяти лет

IP USMF NicolaeTestemiţanu, IMSP SCM SfântaTreime, Conferinţa consacrată aniversării celor 40 de ani de la fondarea SCM Sfânta Treime 17 iunie 2016 Chișinău, Republica MoldovaThis article represents the analysis of activity of the department of internal diseases no.1 of PMSI Municipal Clinical Hospital „Sfanta Treime” in 2006-2015. Thus, an increased prevalence of respiratory diseases and primary detected neoplasms was shown. There was an increase in the number of hospitalization days caused by evolving severe disease, late appeals, presence of multiple comorbidities and slower response to treatment. All these are in line with the panEuropean trend of an aging population and hospitalization of patients with multiple health problems.В статье анализируются данные заболеваемости в 20062015 гг. Наблюдается рост заболеваний респираторного тракта, а также онкологических болезней. Больные госпитализируются в тяжелом и крайне тяжелом состоянии с множеством сопутствующих заболеваний, с запоздалым ответом на лечение. Эти данные согласуются с паневропейским процессом старения населения земного шара с многообразием проблем здоровья

Mezoteliomul pericardial la vârstnic: caz clinic și revista literaturii

Departamentul de medicină internă, Disciplina sinteze clinice, Universitatea de Stat de Medicină şi Farmacie„Nicolae Testemiţanu", Chişinău, Republica Moldova, Spitalul Clinic Municipal „Sfânta Treime“, Chişinău, Republica Moldova, Catedra de histologie, citologie şi embriologie, Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Chişinău, Republica MoldovaResumat Introducere. Mesoteliomul primar al pericardului este o tumoare malignă rară ce rezultă din celulele mezoteliale ale pericardului, cauzată, de obicei, de expunerea anterioară la azbest. Stabilirea diagnosticului in vivo este dificilă din cauza simptomelor nespecifice, definitivarea căruia are loc în urma examenului histopatologic al bioptatului. Scopul studiului a fost de a descrie cazul clinic de mezoteliom la o pacientă vârstnică şi de a prezenta revista literaturii la temă. Material şi metode. Pacienta în vârstă de 81 de ani, spitalizată în secţia de terapie intensivă, a fost examinată detaliat clinic şi paraclinic. Diagnosticul de mezoteliom a fost efectuat post mortem în baza rezultatelor examenului macroscopic, histopatologic şi imunohistochimic. Rezultate. Pacienta a fost internată în stare extrem de gravă, provocată de edem pulmonar acut şi suspiciune de infarct miocardic acut. În pofida tratamentului administrat, starea pacientei a continuat să se deterioreze, cazul fiind soldat cu sfârşit letal. Examenul necroptic a pus în evidenţă o pericardită adezivă şi noduli pericardici cu infiltraţie malignă. Examenul microscopic şi imunohistochimic au furnizat diagnosticul de mezoteliom sarcomatoid al pericardului. Concluzii. Particularităţile cazului prezentat de mezoteliom pericardic au fost: vârsta înaintată, lipsa contactului cu azbest în anamnestic, starea extrem de gravă la internare, simptomatică caracteristică insuficienţei cardiace cu edem pulmonar şi sindrom al insuficienţei multiple de organe.Abstract Introduction. Primary pericardial mesothelioma is a rare malignant tumor resulting from mesothelial cells of pericardium, usually caused by previous exposure to asbestos. Establishing in vivo diagnosis is difficult because of nonspecific symptoms, the completion of which occurs after the histopathological examination of the biopsy. The purpose of the study was to describe a clinical case of mesothelioma in an elderly patient and to give a review of the literature on the topic. Material and methods. An 81-year-old woman hospitalized in the Intensive Care Unit was examined clinically and paradinically in details. The diagnosis of mesothelioma was made post mortem by macroscopic, histopathological and immunohistochemical examination. Results. The patient was admitted in the extremely severe condition, the clinical picture was caused by acute pulmonary edema and suspicion of myocardial infarction. Despite the intensive treatment used the condition of the patient continued to worsen and the patient died. The necropsy revealed adhesive pericarditis and pericardial nodules with malignant infiltration. Microscopical examination and immunohistochemistry diagnosed sarcomatoid mesothelioma of the pericardium. Conclusions. The features of the presented case of pericardial mesothelioma were: advanced age, lack of contact with asbestos in the patient’s history, extremely severe condition on admission, clinical picture of heart failure with acute pulmonary edema and multiorgan dysfunction syndrome