Understanding maturity: insights into the mechanisms underpinning maturity in gadoids

Marked shifts in the life history traits of fish have been reported in many exploited fish stocks, with a particular trend towards decreasing size and age at maturity. Though other environmental and behavioural factors have been implicated, the key driver of these changes links to fishing pressure, through both the direct selective effects of fishing itself, and indirectly through the manipulation of important biological and environmental factors. Although reproduction itself has been well described in teleosts, the mechanisms of environmental and endogenous entrainment of maturation remain unclear and it was the principal aim of this thesis to improve current understanding of these systems in gadoids. Photoperiod has been identified as the strongest environmental cue for entraining seasonal behaviours, including seasonal reproduction. Over the last decade, several of the key drivers involved in the photoneuroendocrine cascade have been elucidated in mammals and birds, with the Eya3 pathway merging as an important mechanism for entraining maturation. However, little is yet known of their influence on maturation in fish. In the first study, the photoperiodic regulation of the Eya3-Tshβ-Dio2 cascade was analysed in Atlantic cod exposed to either continuous light (reproductive inhibition) or simulated natural photoperiod (reproductive stimulation) from July to December. Monthly expression was measured through QPCR, demonstrating a strong activation of pituitary Eya3 under declining photoperiod. As this coincided with the onset of secondary gametogenesis, these results suggest that Eya3 may play a stimulatory role in the photoneuroendocrine cascade of Atlantic cod. Although photoperiod represents the most reliable and noise free proximate signal to entrain the reproductive process, it is clear that a minimum growth and energetic state must be reached for maturation to progress. This directed the second line of study – a series of diet restriction trials on haddock and cod designed to investigate the influence of naturally occurring lipid levels in the diet on growth and reproduction, define the “critical window” in which fish assess their energetic state and how this is analysed before commencing secondary gametogenesis, and to assess whether Eya3 is regulated by the growth axis in cod. The results of these experiments indicate that overall size around the autumn equinox is the most accurate indicator of maturation commitment in cod. Additionally, Eya3 expression was elevated in maturing fish indicating a role for this marker in linking the energetic signal with entrainment of the reproductive axis. Finally, an analysis of the physiological and genetic stock structure of cod from the North Sea IVa stock region and westward into VIa was performed. The results of this analysis support previous genetic studies, indicating further fine-scale structuring of these stocks, reflective of the structure indicate by the differences in maturation strategies of the component populations. The results identified both environmental and harvest related pressures which may be driving the current stock structure. The results of these studies greatly improves our understanding of the key drivers and mechanisms regulating maturation in cod, highlighting new avenues for future researc

A remedial program in fifth grade reading

Thesis (Ed.M.)--Boston University, 1946. This item was digitized by the Internet Archive

Seasonal patterns in newborns’ health: quantifying the roles of climate, communicable disease, economic and social factors

Poor health at birth can have long-term consequences for children’s development. This paper analyses an important factor associated with health at birth: the time of year that the baby is born, and hence seasonal risks they were exposed to in utero. There are multiple potential explanations for seasonality in newborns’ health. Most previous research has examined these in isolation. We therefore do not know which explanations are most important – and hence which policy interventions would most effectively reduce the resulting early-life inequalities. In this paper, I use administrative data to estimate and compare the magnitudes of several seasonal risks, seeking to identify the most important drivers of seasonality in the Northern Territory of Australia, a large territory spanning tropical and arid climates and where newborn health varies dramatically with the seasons. I find that the most important explanations are heat exposure and disease prevalence. Seasonality in food prices and road accessibility have smaller effects on some outcomes. Seasonal fertility patterns, rainfall and humidity do not have statistically significant effects. I conclude that interventions that protect pregnant women from seasonal disease and heat exposure would likely improve newborn health in the Northern Territory, with potential long-term benefits for child development. It is likely that similar impacts would apply in other locations with tropical and arid climates, and that, without action, climate change will accentuate these risks

The challenges of conducting systematic evidence reviews: a case study of factors shaping children’s digital skills

Systematic evidence reviews draw together findings from multiple studies, helping researchers and decision makers to understand patterns of research and findings across varying contexts and research methodologies. They have become more popular over the last twenty years, with various guides discussing the different ways in which they can be conducted and the issues arising in this process. This case study of a systematic review of the factors shaping children’s digital skills explores the challenges, risks and potential strategies in this process, as those involved in that review reflect upon the various judgements involved in choosing inclusion criteria, filtering and coding studies and synthesising the material collected

Determination of the Distribution of the Resident Inshore and Offshore Migratory Cod Populations Around Shetland (IVa) and Westwards into VIa

The current genetic analysis alludes to finer scale structuring of Atlantic cod stocks in the IVa and VIa stock units than had previously been reported by Heath et al. (2014). Consistent with previous studies of maturation, cod from Viking sampled in 2014 matured at a later age and larger size than other areas, providing a phenotypic population marker.  During spawning time there was no indication that the Viking group extended beyond the > 100 m waters of the northern North Sea. Indeed, the new genetic and maturity evidence suggests that Shetland coastal cod (ShIE) appear to extend into waters > 100 m east of Shetland.  The possible separation of cod from Scottish inshore waters from those offshore is also reminiscent of the inshore-offshore division seen in the northern North Sea.  There is some indication of mixing of populations outside the breeding season in the genetic analysis as well as the observation of large immature cod present in west coast samples.  The present study has considerably expanded our understanding of the Viking cod from northern IVa and when combined with the studies by Poulsen et al. (2011) and Heath et al. (2014), provides a good indication of population extent at spawning time and suggests a split around 0030 W

Income and immunity: The consequences of a pre- and neo-natal income shock on childhood infection risk

Objectives The experiences and conditions that children are exposed to in utero and early infancy impact their health in adulthood. Understanding the channels through which these effects emerge is important, because this may help us to anticipate which children are at highest risk of adverse effects, and provide early interventions to help. In this paper, we test a new channel linking perinatal experiences to later-life health: immunity. Method We use administrative birth records, linked with hospital admissions episodes and primary care consultations for children in the Northern Territory of Australia. This data forms part of the Child and Youth Development Partnership data linkage project. We analyse the impact of a shock to household income in Aboriginal communities, resulting from a change in government transfer policy. We estimate the impact of exposure to this shock in utero or in the first 3 months of life, relative to exposure later in childhood, to isolate the impact of an income shock during this key developmental period. Results We find that children who were exposed to the shock in utero or in their first three months of life were at higher risk of severe infection requiring hospital admission. They spend, on average, 4.5 more days in hospital from birth to their 6th birthday (a 45 percent increase). Most of this impact is concentrated in admissions for infection. Only a small share of the effect can be explained by the immediate impact of the policy on birthweight. Conclusion Our findings are consistent with the explanation that an income shock worsens nutrition, and that worse nutrition during key developmental stages can permanently weaken children’s immune systems. This finding speaks to the importance of attention to key phases in childhood development, when designing policies that affect households’ financial resources. Furthermore, we find birthweight is a poor predictor of childhood hospital admission. However, use of longitudinal administrative data helps us to identify alternative markers of new-born health that are better predictors

Transition of Experienced and New Graduate Nurses to a Pediatric Hospital

This study reports on the 3-, 6-, 12-, and 18-month outcomes of 118 newly hired registered nurses (RNs) who completed a 12-month transition-to-practice program at a pediatric hospital. Experienced RNs (n = 42) and new graduate RNs (n = 76) showed improved organization, prioritization, communication, and leadership skills over time. The experienced RNs reported better communication and leadership skills than the new graduate nurses. Results inform transition program development for both new and experienced nurses. The American Association of Colleges of Nursing (2012) predicts that, without a multifaceted approach, a national nursing shortage will occur by 2020. Many nurses leave their first position and sometimes the profession within the first year of employment (Baxter, 2010; Welding, 2011). Retaining nurses is a vital component of any approach to averting a nursing shortage. In an attempt to retain nurses, healthcare institutions often provide a transition-to-practice (TTP) or nurse residency program for new graduate nurses (NGN) entering the profession. The Institute of Medicine (2011) in its Future of Nursing report also recommends a transition program for nurses moving to a new specialty or to advanced practice roles. Completing a NGN transition program is associated with a decrease in nurse attrition by as much as 80% (Halfer, Graf, & Sullivan, 2008; Rush, Adamack, Gordon, Lilly, & Janke, 2013; Spector et al., 2015). This reported decrease has led to organizational interest in transition programs to improve retention. The goals of residency programs for the NGN have ranged from increasing new nurse confidence and competence, to increasing satisfaction and retention (Fink, Krugman, Casey, & Goode, 2008; Goode, Lynn, McElroy, Bednash, & Murray, 2013; Institute of Medicine, 2011; Spector et al., 2015). Although literature supports the effectiveness of transition programs for the NGN (Fink et al., 2008; Goode et al., 2013; Spector et al., 2015), there is little evidence on the experienced nurse’s transition to a new specialty practice. Furthermore, most transition programs do not report outcomes beyond the first 12 months of employment. Thus, the purpose of this study is to evaluate nurse stressors and supports during and after a 12-month transition-to-employment program for both new and experienced nurses transitioning to a pediatric practice

Some Observations of Short-eared Owl, Asio flammeus, Ecology on Arctic Tundra, Yukon, Canada

We investigated nesting behavior, food habits, and interspecific interactions of Short-eared Owls (Asio flammeus) within an arctic tundra raptor community on Herschel Island and Komakuk Beach, northern Yukon, Canada. Short-eared Owls were the least common nesting raptor. We found only three nests, all on Herschel Island. All nests were on relatively elevated sites with fairly substantial vegetative cover. All nests failed in the egg stage, from a combination of human disturbance and possible predation by Arctic Fox (Vulpes lagopus) or Red Fox (Vulpes vulpes). Short-eared Owls nested only in years when small rodent densities were at least 4 to 5 individuals per hectare in the spring. Short-eared Owls ate Northern Collared Lemmings (Dicrostonyx groenlandicus), Brown Lemmings (Lemmus trimucronatus), and Tundra Voles (Microtus oeconomus) almost exclusively, without clear selectivity. Peregrine Falcons (Falco peregrinus) killed two adult Short-eared Owls. In northern Yukon, the Short-eared Owl remains an uncommon summer resident and uses the region as a migration route. Spring rodent densities and interspecific predation are prominent limiting factors, and human disturbance also limits nesting success. We recommend restricting access to most tundra areas during periods when the birds are mating, initiating nesting, and incubating eggs. We recommend that human infrastructure be designed so that it cannot support novel nesting (and therefore local range expansion) by other nesting raptors that compete with and prey on Short-earned Owls

Aquilegia, Vol. 26 No. 1, January-February 2002: Newsletter of the Colorado Native Plant Society

https://epublications.regis.edu/aquilegia/1091/thumbnail.jp

What can we learn from administrative benefits data?

We present the opportunities and limitations of administrative benefits data held by local authorities for data linkage projects. Whilst the richness of this data has been exploited by practitioners for administration, its potential remains little explored by researchers. We discuss data quality, sample selection and legal gateways for data sharing. Drawing on our experience working with over 40 local authorities, we present the structure of three datasets: the Council Tax Reduction Scheme, the Single Housing Benefits Extract and the Universal Credit Data Share. We show what variables are usually included, under which legal gateways this data can be shared and how the cohorts represented within the data compare with the low-income population. We discuss how these datasets can be linked at the household level with a number of other data held by local authorities such as social rent and Council Tax arrears, Housing Benefit overpayments and Discretionary Housing Payments (DHPs). Administrative benefits data provides a comprehensive snapshot of a household’s financial situation. Local authorities can proactively use and share this data with external data processors to fulfil their statutory duties if a legal gateway allows. By identifying households at risk of cash shortfalls before they reach a crisis point, councils can target support when administering local welfare schemes and preventing homelessness. By assessing eligibility for benefits, they can run data-driven uptake campaigns. This data captures a proportion of the population on national and local benefits within a local authority at several points in time. Attrition is of concern since households may leave datasets over time. Some will see their income rise and no longer qualify for benefits. Others will move out of the constituency. Local authorities routinely process longitudinal data on households receiving means-tested benefits by administering housing benefits, council tax support, and discretionary support funds. This data provides a unique real-time insight into the socioeconomic situation of low-income households. Yet, we show that its promising potential for policy research remains largely untapped