2,146 research outputs found
The Assignment: How the Videographer\u27s Role is Shaped by the Job Assignment
I am a videographer. Yes, my degree will qualify me as a reporter, someone familiar with the inner workings of a news station. However, I posit that the School of Journalism and Broadcasting does not give you a career, but rather a skillset that prepares you for a range of jobs. My discipline taught me how to articulate my thoughts in a clear, concise manner, which translates well to script or track writing. In addition, I have technical abilities that enable me to handle video and audio equipment proficiently. Combining these capabilities with soft skills I honed over the past few years on the Forensics team, I am what the industry would call a one-man-band. As such, I can implement each strength in the best way I see fit. The variable that most often alters how I manage my attributes on an individual production is the job assignment. Even though I may use the same equipment, the job assignment changes the storytelling process. My thesis project further delves into this idea by drawing on personal examples, as well as, times in the media where someone crossed the precarious line between agenda driven production and news media
Innate Immune Responses in Viral Hepatitis: the role of Kupffer cells and liver-derived monocytes in shaping intrahepatic immunity in mice using the LCMV infection model
__Abstract__
This study was performed to elucidate the immunological role of the liver in viral
hepatitis. The immune functions of the liver are shaped by the intrahepatic cells present during
steady state condition, as well as the recruited immune cells during liver inflammation. Liver
resident Kupffer cells, by performing endocytosis, determine the functionality of the liver as a
filtering organ. Additionally, Kupffer cells produce IL-10. This function, regulated by Ctcf,
suggests the potential of Kupffer cells to perform immunoregulation. Monocytes patrol the liver
in the steady state, but accumulate in the liver during viral hepatitis. They show functional
versatility as demonstrated in the distinct polarization towards TNF-producing and endocytic
cells in LCMV-infected and LPS-treated livers, respectively. During LCMV-induced hepatitis,
fractions of both Kupffer cells and inflammatory monocytes alter their F4/80 expression, posing
a challenge in immunological studies using flow cytometry. Furthermore, in this study we
describe distinct clinical responses induced by TLR7 treatment at different phases of LCMV
infection, which are associated with distinct states of immune activation.
Results from our study contribute to better understand the regulation of intrahepatic
immune responses in the steady state condition and during viral hepatitis. Better insights in the
functions of Kupffer cells and inflammatory monocytes will open up their potential to be targeted
by HBV and HCV therapy. Furthermore, this study emphasizes the importance of characterizing
the intrahepatic immune responses during chronic viral hepatitis to understand the mechanisms
for the induction of adverse side-effects by TLR7 treatment. This information is valuable in order
to prevent or predict the clinical outcome of TLR7-based treatment of HBV or HCV patients.
Although this need to be validated in more detail, our findings suggest the significance of
evaluating the TLR7 expression levels, either intrahepatic or systemic, in chronically infected
patients prior to TLR7 treatment to minimalize the occurrence of adverse side-effects
Children's Databases - Safety and Privacy
This report describes in detail the policy background, the systems that are being built, the problems with them, and the legal situation in the UK. An appendix looks at Europe, and examines in particular detail how France and Germany have dealt with these issues. Our report concludes with three suggested regulatory action strategies for the Commissioner: one minimal strategy in which he tackles only the clear breaches of the law, one moderate strategy in which he seeks to educate departments and agencies and guide them towards best practice, and finally a vigorous option in which he would seek to bring UK data protection practice in these areas more in line with normal practice in Europe, and indeed with our obligations under European law
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