Computing Variances from Data with Complex Sampling Designs: A Comparison of Stata and SPSS

Most of the data sets available through the National Center for Education Statistics (NCES) are based on complex sampling designs involving multi-stage sampling, stratification, and clustering. These complex designs require appropriate statistical techniques to calculate the variance. Stata employs specialized methods that appropriately adjust for the complex designs, while SPSS does not. Researchers using SPSS must obtain the design effects through NCES and adjust the standard errors generated by SPSS with these values. This presentation addresses the pros and cons of recommending Stata or SPSS to novice researchers. The first presenter teaches research methods to doctoral students and uses Stata to conduct research with NCES data. She uses SPSS to teach her research methods course, due to its user-friendly interface. The second presenter is a doctoral student conducting dissertation research with NCES data. In his professional life as an institutional researcher, he uses SPSS. NCES data sets are a rich resource, but the complex sampling designs create conceptual issues beyond the immediate grasp of most doctoral candidates in the field. The session considers and invites comment on the best approaches to introducing new researchers to complex sampling designs in order to enable them to use NCES data.

ThermoPhyl : a software tool for selecting phylogenetically optimized conventional and quantitative-PCR taxon-targeted assays for use with complex samples

The ability to specifically and sensitively target genotypes of interest is critical for the success of many PCR-based analyses of environmental or clinical samples that contain multiple templates.Next-generation sequence data clearly show that such samples can harbour hundreds to thousands of operational taxonomic units; a richness which precludes the manual evaluation of candidate assay specificity and sensitivity using multiple sequence alignments. To solve this problem we have developed and validated a free software tool which automates the identification of PCR assays targeting specific genotypes in complex samples. ThermoPhyl uses user-defined target and non-target sequence databases to assess the phylogenetic sensitivity and specificity of thermodynamically optimised candidate assays derived from primer design software packages. ThermoPhyl takes its name from its central premise of testing Thermodynamically optimal assays for Phylogenetic specificity and sensitivity and can be used for two primer (traditional PCR) or two primers with an internal probe (e.g. TaqMan® qPCR) applications and potentially for oligonucleotide probes.Here we describe the use of ThermoPhyl for traditional PCR and qPCR assays. PCR assays selected using ThermoPhyl were validated using 454 pyrosequencing of a traditional specific PCR assay and with a set of four genotype-specific qPCR assays applied to estuarine sediment samples

Promoting Academic Integrity in Health Occupations Education

This article reviews the concept of academic integrity and its promotion by health occupations education faculty. Academic integrity is the use of a student’s own work only; thus, an absence of any form of cheating or plagiarism is assumed. Since a lack of academic integrity can translate into later unethical behaviors by students in clinical settings, health occupations teachers have an obligation to promote academic integrity and prevent student cheating. In addition to reviewing concepts of academic integrity and plagiarism, this article provides specific recommendations for health occupations education programs

Targeting delivery in Parkinson's disease

Disease-modifying therapies for Parkinson's disease (PD), with the potential to halt the neurodegenerative process and to stimulate the protection, repair, and regeneration of dopaminergic neurons, remain a vital but unmet clinical need. Targeting the delivery of current and new therapeutics directly to the diseased brain region (in particular the nigrostriatal pathway) could result in greater improvements in the motor functions that characterise PD. Here, we highlight some of the opportunities and challenges facing the development of the next generation of therapies for patients with PD

The Mental Health Benefits of Acquiring a Home in Older Age: A Fixed-Effects Analysis of Older US Adults.

Homeownership is consistently associated with better mental health, but whether becoming a homeowner in later in life has positive psychological benefits has not, to our knowledge, been examined. We assessed whether acquiring a home after age 50 years was associated with depression in a representative sample of older US adults. We used individual fixed-effects models based on data from 20,524 respondents aged ≥50 years from the Health and Retirement Study, who were interviewed biennially during 1993-2010. Depressive symptoms were measured using the 8-item Center for Epidemiologic Studies Depression Scale. Controlling for confounders, becoming a homeowner in later life predicted a decline in depressive symptoms in the same year (β = -0.0768, 95% confidence interval (CI): -0.152, -0.007). The association remained significant after 2 years (β = -0.0556, 95% CI: -0.134, -0.001) but weakened afterward. Buying a home for reasons associated with positive characteristics of the new house or neighborhood drove this association (β = -0.426, 95% CI: -0.786, -0.066), while acquiring a home for reasons associated with characteristics of the previous home or neighborhood, the desire to be closer to relatives, downsizing, or upsizing did not predict mental health improvements. Findings suggest that there are small but significant benefits for mental health associated with acquiring a home in older age

Social determinants and BCG efficacy: a call for a socio-biological approach to TB prevention.

A high burden of TB mortality persists despite the long-term availability of the bacillus Calmette-Guérin (BCG) vaccine, whose efficacy has been highly variable across populations. Innovative and alternative approaches to TB prevention are urgently needed while optimal biomedical tools continue to be developed. We call for new interdisciplinary collaborations to expand and integrate our understanding of how social determinants influence the biological processes that lead to TB disease, how this translates into differential BCG efficacy and, ultimately, how social protection interventions can play a role in reducing the global burden of TB. After providing an overview of the immune pathways important for the establishment of a response to the BCG vaccine, we outline how social determinants and psychosocial stressors can contribute to the observed variation in BCG efficacy above and beyond these biological factors. We conclude by proposing a new interdisciplinary research model based on the integration of social epidemiology theories with biomedical knowledge

Essential Coaching Skills for Affective Development

The goal of coaching for school improvement generally focuses on academic achievement. Coaching is often centered on raising test scores and ensuring that all students achieve academic standards. The effectiveness of coaching can also be found in its usefulness for developing affective skills in both teachers as well as students. Essential coaching skills of listening, paraphrasing, presuming positive intent, asking powerful questions, and providing reflective feedback can be paired with a focus on relationships and relatedness between coach and teacher, teacher candidate or student to positively impact the climate and culture of a classroom. With that in mind, coaching for affective development addresses the development of rapport, respect, and responsiveness to student needs. Utilizing coaching skills to develop students in both affective and academic domains strengthens the power of the coaching relationship

Diversity Matters: Race, Gender and Ethnicity in Legal Education.

This Article presents more evidence of the inequality that persists in legal education for students. Based on a survey of University of Florida law students conducted in 2001, this study reaffirms the existence of differential experience and an inegalitarian culture in legal education. However, it also demonstrates the importance of diversity and the recognition by a significant majority of students of the value of race and gender pluralism. These competing findings provide a clear guide to the future direction of legal education

Advances in X-Ray Computed Microtomography at the NSLS.

The X-Ray Computed Microtomography workstation at beamline X27A at the NSLS has been utilized by scientists from a broad range of disciplines from industrial materials processing to environmental science. The most recent applications are presented here as well as a description of the facility that has evolved to accommodate a wide variety of materials and sample sizes. One of the most exciting new developments reported here resulted from a pursuit of faster reconstruction techniques. A Fast Filtered Back Transform (FFBT) reconstruction program has been developed and implemented, that is based on a refinement of the ''gridding'' algorithm first developed for use with radio astronomical data. This program has reduced the reconstruction time to 8.5 sec for a 929 x 929 pixel{sup 2} slice on an R10,000 CPU, more than 8x reduction compared with the Filtered Back-Projection method