The effects of the direct instruction with computer-assisted instruction in reading for students with learning disabilities

The purposes of this study were: (a) to examine the effects of using the Direct Instruction Reading Mastery program along with Computer-assisted instruction to enhance the students\u27 vocabulary learning; (b) to examine the effects of using the Direct Instruction Reading Mastery program in reading along with Computer-assisted instruction to enhance the students\u27 reading comprehension; (c) to evaluate if students display a higher level of satisfaction in reading when taught with the Direct Instruction Reading Mastery program followed with computer-assisted instruction. Nine 5th grade students with learning disabilities in a resource room participated in the study. A multiple baseline design across students was used in the study. Baseline data of four weeks was collected based on student test scores followed by interventions (intervention I - Direct Instruction Reading Mastery program, intervention II - Direct Instruction Reading Mastery program with computer-assisted instruction). Each intervention lasted for four weeks. The findings of the study showed student gains in reading achievement both in vocabulary and comprehension in the intervention phases. The results also showed student satisfaction in learning

\u3ci\u3eDrosophila\u3c/i\u3e Muller F Elements Maintain a Distinct Set of Genomic Properties Over 40 Million Years of Evolution

The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the genes on the D. erecta, D. mojavensis, and D. grimshawi F elements and euchromatic domains from the Muller D element. We find that F elements have greater transposon density (25–50%) than euchromatic reference regions (3–11%). Among the F elements, D. grimshawi has the lowest transposon density (particularly DINE-1: 2% vs. 11–27%). F element genes have larger coding spans, more coding exons, larger introns, and lower codon bias. Comparison of the Effective Number of Codons with the Codon Adaptation Index shows that, in contrast to the other species, codon bias in D. grimshawi F element genes can be attributed primarily to selection instead of mutational biases, suggesting that density and types of transposons affect the degree of local heterochromatin formation. F element genes have lower estimated DNA melting temperatures than D element genes, potentially facilitating transcription through heterochromatin. Most F element genes (~90%) have remained on that element, but the F element has smaller syntenic blocks than genome averages (3.4–3.6 vs. 8.4–8.8 genes per block), indicating greater rates of inversion despite lower rates of recombination. Overall, the F element has maintained characteristics that are distinct from other autosomes in the Drosophila lineage, illuminating the constraints imposed by a heterochromatic milieu