Increasing frailty is associated with higher prevalence and reduced recognition of delirium in older hospitalised inpatients: results of a multi-centre study

Purpose: Delirium is a neuropsychiatric disorder delineated by an acute change in cognition, attention, and consciousness. It is common, particularly in older adults, but poorly recognised. Frailty is the accumulation of deficits conferring an increased risk of adverse outcomes. We set out to determine how severity of frailty, as measured using the CFS, affected delirium rates, and recognition in hospitalised older people in the United Kingdom. Methods: Adults over 65 years were included in an observational multi-centre audit across UK hospitals, two prospective rounds, and one retrospective note review. Clinical Frailty Scale (CFS), delirium status, and 30-day outcomes were recorded. Results: The overall prevalence of delirium was 16.3% (483). Patients with delirium were more frail than patients without delirium (median CFS 6 vs 4). The risk of delirium was greater with increasing frailty [OR 2.9 (1.8–4.6) in CFS 4 vs 1–3; OR 12.4 (6.2–24.5) in CFS 8 vs 1–3]. Higher CFS was associated with reduced recognition of delirium (OR of 0.7 (0.3–1.9) in CFS 4 compared to 0.2 (0.1–0.7) in CFS 8). These risks were both independent of age and dementia. Conclusion: We have demonstrated an incremental increase in risk of delirium with increasing frailty. This has important clinical implications, suggesting that frailty may provide a more nuanced measure of vulnerability to delirium and poor outcomes. However, the most frail patients are least likely to have their delirium diagnosed and there is a significant lack of research into the underlying pathophysiology of both of these common geriatric syndromes

Coetzee on Film

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Topoisomerase IIα Is Required for Embryonic Development and Liver Regeneration in Zebrafish▿

Topoisomerases solve the topological problems encountered by DNA throughout the lifetime of a cell. Topoisomerase IIα, which is highly conserved among eukaryotes, untangles replicated chromosomes during mitosis and is absolutely required for cell viability. A homozygous lethal mutant, can4, was identified in a screen to identify genes important for cell proliferation in zebrafish by utilizing an antibody against a mitosis-specific marker, phospho-histone H3. Mutant embryos have a decrease in the number of proliferating cells and display increases in DNA content and apoptosis, as well as mitotic spindle defects. Positional cloning revealed that the genetic defect underlying these phenotypes was the result of a mutation in the zebrafish topoisomerase IIα (top2a) gene. top2a was found to be required for decatenation but not for condensation in embryonic mitoses. In addition to being required for development, top2a was found to be a haploinsufficient regulator of adult liver regrowth in zebrafish. Regeneration analysis of other adult tissues, including fins, revealed no heterozygous phenotype. Our results confirm a conserved role for TOP2A in vertebrates as well as a dose-sensitive requirement for top2a in adults

Collaborative teaching-learning for future teachers training in multimodal and transcultural genre pedagogy in L1 and L2

El proyecto supone la continuación de otros PID y de Aprendizaje por Servicio (ApS) desarrollados por el grupo ForMuLE (Multilingüismo, (multi)Literacidad y Educación Lingüística), centrados en la formación docente para la mejora de competencias discursivas en español y en inglés, en la Educación Primaria (véase el repositorio Docta Complutense y últimas publicaciones del grupo: monográfico de la revista Didacticae, 14. Octubre, 2023; participación en Rose, C. Acevedo y R. Whittaker (Eds.), Reading to Learn, Reading the World: How genre-based literacy pedagogy is democratizing education (pp. 161-176). Equinox).La finalidad de este proyecto es diseñar, implementar y evaluar una propuesta de trabajo colaborativo transcultural en los Grados de Formación de Profesorado, especialmente en lo que se refiere a su formación para el desarrollo de la (multi)literacidad en las diferentes áreas del currículum y en las diferentes lenguas implicadas en la educación básica obligatoria (español e inglés). La propuesta incluye dos elementos principales: (i) formación en el modelo Reading to Learn (Rose & Martin, 2012) a través del conocimiento de clasificación de los géneros discursivos que subyace en él, y (ii) el trabajo colaborativo transcultural para conocer manifestaciones culturales diversas, con la creación de grupos de trabajo compuestos por estudiantes de las universidades del País Vasco, Universidad del Norte (Colombia), Rutgers University (New Jersey, EEUU) y la UCM . Así, se pretende incidir tanto en la formación profesional y lingüística de futuros docentes como en desarrollo de competencias transversales tales como la capacidad de trabajo en equipo y el desarrollo de competencias interculturales globales. En el documento se describe el procedimiento de diseño, implementación y evaluación de la experiencia, así como todos los instrumentos diseñados y utilizados en cada una de las fases del proyecto.Universidad Complutense de MadridDepto. de Didáctica de las Lenguas, Artes y Educación FísicaFac. de EducaciónFALSEsubmitte