South West Creative Technology Network - Final report

This report highlights the research and development conducted during the 3-year South West Creative Technology Network. It outlines the creative knowledge exchange methodology developed through the programme and provides case studies of our Immersion, Automation and Data R&D themes

Bristol and Bath by Design; To understand the economic and cultural value of design in the Bristol and Bath region

The aim of the project was to collect data on designcompanies in the Bristol and Bath region, and to gain abetter understanding of the economic and cultural valueof the design-led sector. To do this, our primary researchwas to develop a range of qualitative and quantitativemethods that could gather and then analyse the data

Digital music libraries - Research and development

A report on the progress of several major research and development projects in digital music libraries is presented. Digital music libraries provide enhanced access and functionality that facilitates scholarly research and education. The issue of integrating digital music library collections with interactive instructional applications is addressed

Schools and skills of critical thinking for urban design

© 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group. This paper explores possible ways in which urban design can engage with critical thinking and critical theory. After a brief explanation of the terms, with particular attention to the Frankfurt School of thought, it provides various answers to the question as to whether urban design is critical or not. One categorization applied to planning critical theory is then used to explain the potential for employing critical theories in urban design. Critical thinking skills are then argued to be helpful for enriching the literature of urban design in order to achieve better practice. The conclusion is that urban design can benefit from critical creativity, which is an embodiment of critical thinking within the limits imposed onto creativity. In this paper, the ways in which urban design can engage with both critical theory and with critical thinking are explored in order to achieve better critical creativity in the field

The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models.

BACKGROUND: Melanoma is the most deadly form of skin cancer. Expression of oncogenic BRAF or NRAS, which are frequently mutated in human melanomas, promote the formation of nevi but are not sufficient for tumorigenesis. Even with germline mutated p53, these engineered melanomas present with variable onset and pathology, implicating additional somatic mutations in a multi-hit tumorigenic process. RESULTS: To decipher the genetics of these melanomas, we sequence the protein coding exons of 53 primary melanomas generated from several BRAF(V600E) or NRAS(Q61K) driven transgenic zebrafish lines. We find that engineered zebrafish melanomas show an overall low mutation burden, which has a strong, inverse association with the number of initiating germline drivers. Although tumors reveal distinct mutation spectrums, they show mostly C > T transitions without UV light exposure, and enrichment of mutations in melanogenesis, p53 and MAPK signaling. Importantly, a recurrent amplification occurring with pre-configured drivers BRAF(V600E) and p53-/- suggests a novel path of BRAF cooperativity through the protein kinase A pathway. CONCLUSION: This is the first analysis of a melanoma mutational landscape in the absence of UV light, where tumors manifest with remarkably low mutation burden and high heterogeneity. Genotype specific amplification of protein kinase A in cooperation with BRAF and p53 mutation suggests the involvement of melanogenesis in these tumors. This work is important for defining the spectrum of events in BRAF or NRAS driven melanoma in the absence of UV light, and for informed exploitation of models such as transgenic zebrafish to better understand mechanisms leading to human melanoma formation

We’re happy and we know it : Documentary: Data: Montage

This article is concerned with the social praxis of documentary in the sea of ‘ubiquitous data’ that is both consequence and driver of online social mediation. The topic is given importance by the morphing of the character of video in the context of the latest web coding language, HTML5. Until now web video has been impervious to its networked context; reproducing the conditions of the TV screen in a hypermediated space. Now existing databases and live information drawn from social media can be connected to the documentary environment, offering opportunities for the production of new kinds of knowledge and application. The affordances of networked connectivity offer the potential to re-contextualise documentary material through mobilising the enormous co-creative potential of human discourse captured in the web. The challenge in these marriages of mass media form and rhizomatic network is to find new ways of shaping attention into a coherent experience. To do so we have to re-invent the social praxis of documentary, creating new visual and informational grammars