111 research outputs found
--Dependence of Bond Energies in Double--- Hypernuclei
The -dependence of the bond energy of the
hypernuclear ground states is calculated in a three-body
model and in the Skyrme-Hartree-Fock approach.
Various and -nucleus or potentials
are used and the sensitivity of to the interactions
is discussed. It is shown that in medium and heavy
hypernuclei, is a linear function of
, where is rms radius of the hyperon orbital. It
looks unlikely that it will be possible to extract
interaction from the double- hypernuclear energies only, the
additional information about the -core interaction, in particular, on
is needed.Comment: 11 pages, LaTex, 3 figure
Compact Stars - How Exotic Can They Be?
Strong interaction physics under extreme conditions of high temperature
and/or density is of central interest in modern nuclear physics for
experimentalists and theorists alike. In order to investigate such systems,
model approaches that include hadrons and quarks in a unified approach, will be
discussed. Special attention will be given to high-density matter as it occurs
in neutron stars. Given the current observational limits for neutron star
masses, the properties of hyperonic and hybrid stars will be determined. In
this context especially the question of the extent, to which exotic particles
like hyperons and quarks affect star masses, will be discussed.Comment: Contributon to conference "Nuclear Physics: Present and Future", held
in Boppard (Germany), May 201
Consistency of Lambda-Lambda hypernuclear events
Highlights of Lambda-Lambda emulsion events are briefly reviewed. Given three
accepted events, shell-model predictions based on p-shell Lambda hypernuclear
spectroscopic studies are shown to reproduce the Lambda-Lambda (LL) binding
energies of LL10Be and LL13B in terms of the LL binding energy of LL6He.
Predictions for other species offer judgement on several alternative
assignments of the LL13B KEK-E176 event, and on the assignments LL11Be and
LL12Be suggested recently for the KEK-E373 HIDA event. The predictions of the
shell model, spanning a wide range of A values, are compared with those of
cluster models, where the latter are available.Comment: Based on talk given by Avraham Gal at EXA 2011, Vienna, September
2011; Proceedings version prepared for the journal Hyperfine Interactions;
v2--slight changes, matches published versio
Search for Exotic Strange Quark Matter in High Energy Nuclear Reactions
We report on a search for metastable positively and negatively charged states
of strange quark matter in Au+Pb reactions at 11.6 A GeV/c in experiment E864.
We have sampled approximately six billion 10% most central Au+Pb interactions
and have observed no strangelet states (baryon number A < 100 droplets of
strange quark matter). We thus set upper limits on the production of these
exotic states at the level of 1-6 x 10^{-8} per central collision. These limits
are the best and most model independent for this colliding system. We discuss
the implications of our results on strangelet production mechanisms, and also
on the stability question of strange quark matter.Comment: 21 pages, 9 figures, to be published in Nuclear Physics A (Carl Dover
memorial edition
Search for Strange Quark Matter Produced in Relativistic Heavy Ion Collisions
We present the final results from Experiment 864 of a search for charged and
neutral strange quark matter produced in interactions of 11.5 GeV/c per nucleon
Au beams with Pt or Pb targets. Searches were made for strange quark matter
with A>4. Approximately 30 billion 10% most central collisions were sampled and
no strangelet states with A<100 were observed. We find 90% confidence level
upper limits of approximately 10^{-8} per central collision for both charged
and neutral strangelets. These limits are for strangelets with proper lifetimes
greater than 50 ns. Also limits for H^{0}-d and pineut production are given.
The above limits are compared with the predictions of various models. The
yields of light nuclei from coalescence are measured and a penalty factor for
the addition of one nucleon to the coalescing nucleus is determined. This is
useful in gauging the significance of our upper limits and also in planning
future searches for strange quark matter.Comment: 35 pages, 18 figures, submitted to Phys. Rev.
Adaptive and maladaptive consequences of βmatching habitat choice:β lessons from a rapidly-evolving butterfly metapopulation
Relationships between biased dispersal and local adaptation are currently debated. Here, I show how prior work on wild butterflies casts a novel light on this topic. βPreferenceβ is defined as the set of likelihoods of accepting particular resources after encountering them. So defined, butterfly oviposition preferences are heritable habitat adaptations distinct from both habitat preference and biased dispersal, but influencing both processes. When a butterfly emigrates after its oviposition preference begins to reduce realized fecundity, the resulting biased dispersal is analogous to that occurring when a fish emigrates after its morphological habitat adaptations reduce its feeding rate. I illustrate preference-biased dispersal with examples from metapopulations of Melitaea cinxia and Euphydryas editha. E. editha were feeding on a well-defended host, Pedicularis, when humans created patches in which Pedicularis was killed and a less-defended host, Collinsia, was rendered phenologically available. Patch-specific natural selection favoured oviposition on Collinsia in logged (βclearingβ) patches and on Pedicularis in undisturbed open forest. Quantitative variation in post-alighting oviposition preference was heritable, and evolved to be consistently different between patch types. This difference was driven more by biased dispersal than by spatial variation of natural selection. Insects developing on Collinsia in clearings retained adaptations to Pedicularis in clutch size, geotaxis and oviposition preference, forcing them to choose between emigrating in search of forest habitats with Pedicularis or staying and failing to find their preferred host. Insects that stayed suffered reduction of realized fecundity after delayed oviposition on Collinsia. Those that emigrated suffered even greater fitness penalty from consistently low offspring survival on Pedicularis. Paradoxically, most emigrants reduced both their own fitness and that of the recipient populations by dispersing from a benign natal habitat to which they were maladapted into a more demanding habitat to which they were well-adapted. βMatching habitat choiceβ reduced fitness when evolutionary lag rendered traditional cues unreliable in a changing environment
Histone deacetylase inhibitors: clinical implications for hematological malignancies
Histone modifications have widely been implicated in cancer development and progression and are potentially reversible by drug treatments. The N-terminal tails of each histone extend outward through the DNA strand containing amino acid residues modified by posttranslational acetylation, methylation, and phosphorylation. These modifications change the secondary structure of the histone protein tails in relation to the DNA strands, increasing the distance between DNA and histones, and thus allowing accessibility of transcription factors to gene promoter regions. A large number of HDAC inhibitors have been synthesized in the last few years, most being effective in vitro, inducing cancer cells differentiation or cell death. The majority of the inhibitors are in clinical trials, unlike the suberoylanilide hydroxamic acid, a pan-HDACi, and Romidepsin (FK 228), a class I-selective HDACi, which are only approved in the second line treatment of refractory, persistent or relapsed cutaneous T-cell lymphoma, and active in approximately 150 clinical trials, in monotherapy or in association. Preclinical studies investigated the use of these drugs in clinical practice, as single agents and in combination with chemotherapy, hypomethylating agents, proteasome inhibitors, and MTOR inhibitors, showing a significant effect mostly in hematological malignancies. The aim of this review is to focus on the biological features of these drugs, analyzing the possible mechanism(s) of action and outline an overview on the current use in the clinical practice
Platelet Activating Factor Blocks Interkinetic Nuclear Migration in Retinal Progenitors through an Arrest of the Cell Cycle at the S/G2 Transition
Nuclear migration is regulated by the LIS1 protein, which is the regulatory subunit of platelet activating factor (PAF) acetyl-hydrolase, an enzyme complex that inactivates the lipid mediator PAF. Among other functions, PAF modulates cell proliferation, but its effects upon mechanisms of the cell cycle are unknown. Here we show that PAF inhibited interkinetic nuclear migration (IKNM) in retinal proliferating progenitors. The lipid did not, however, affect the velocity of nuclear migration in cells that escaped IKNM blockade. The effect depended on the PAF receptor, Erk and p38 pathways and Chk1. PAF induced no cell death, nor a reduction in nucleotide incorporation, which rules out an intra-S checkpoint. Notwithstanding, the expected increase in cyclin B1 content during G2-phase was prevented in the proliferating cells. We conclude that PAF blocks interkinetic nuclear migration in retinal progenitor cells through an unusual arrest of the cell cycle at the transition from S to G2 phases. These data suggest the operation, in the developing retina, of a checkpoint that monitors the transition from S to G2 phases of the cell cycle
Identification of Lysine 37 of Histone H2B as a Novel Site of Methylation
Recent technological advancements have allowed for highly-sophisticated mass spectrometry-based studies of the histone code, which predicts that combinations of post-translational modifications (PTMs) on histone proteins result in defined biological outcomes mediated by effector proteins that recognize such marks. While significant progress has been made in the identification and characterization of histone PTMs, a full appreciation of the complexity of the histone code will require a complete understanding of all the modifications that putatively contribute to it. Here, using the top-down mass spectrometry approach for identifying PTMs on full-length histones, we report that lysine 37 of histone H2B is dimethylated in the budding yeast Saccharomyces cerevisiae. By generating a modification-specific antibody and yeast strains that harbor mutations in the putative site of methylation, we provide evidence that this mark exist in vivo. Importantly, we show that this lysine residue is highly conserved through evolution, and provide evidence that this methylation event also occurs in higher eukaryotes. By identifying a novel site of histone methylation, this study adds to our overall understanding of the complex number of histone modifications that contribute to chromatin function
H3 Lysine 4 Is Acetylated at Active Gene Promoters and Is Regulated by H3 Lysine 4 Methylation
Methylation of histone H3 lysine 4 (H3K4me) is an evolutionarily conserved modification whose role in the regulation of gene expression has been extensively studied. In contrast, the function of H3K4 acetylation (H3K4ac) has received little attention because of a lack of tools to separate its function from that of H3K4me. Here we show that, in addition to being methylated, H3K4 is also acetylated in budding yeast. Genetic studies reveal that the histone acetyltransferases (HATs) Gcn5 and Rtt109 contribute to H3K4 acetylation in vivo. Whilst removal of H3K4ac from euchromatin mainly requires the histone deacetylase (HDAC) Hst1, Sir2 is needed for H3K4 deacetylation in heterochomatin. Using genome-wide chromatin immunoprecipitation (ChIP), we show that H3K4ac is enriched at promoters of actively transcribed genes and located just upstream of H3K4 tri-methylation (H3K4me3), a pattern that has been conserved in human cells. We find that the Set1-containing complex (COMPASS), which promotes H3K4me2 and -me3, also serves to limit the abundance of H3K4ac at gene promoters. In addition, we identify a group of genes that have high levels of H3K4ac in their promoters and are inadequately expressed in H3-K4R, but not in set1Ξ mutant strains, suggesting that H3K4ac plays a positive role in transcription. Our results reveal a novel regulatory feature of promoter-proximal chromatin, involving mutually exclusive histone modifications of the same histone residue (H3K4ac and H3K4me)
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