Some Alterations of Genetic Expression in two Differently Deviated Hepatomas

SUMMARYSome aspects of the metabolism of proteins and of RNA have been investigated in normal rat liver and in two hepatomas, namely the slowly-growing well differentiated Morris hepatoma 5123, and the rapidly-growing strong anaplastic Yoshida ascites hepatoma A. H. 130. The results presented concern the rate of protein and RNA synthesis, the polysome patterns, the stability of messenger RNA and the changes of nuclear pulse labelled RNA as revealed by DNA/RNA hybridization.On the whole, the results suggest that large qualitative differences in the synthesis of nuclear RNA occur in hepatomas. This finding is discussed briefly in connection with the problem of neoplastic transformation